Establishing reference values for mean notch depth index, pulsatility index and resistance index in the uterine artery at 16-23 weeks' gestation

2012 ◽  
Vol 38 (11) ◽  
pp. 1275-1285 ◽  
Author(s):  
Kayo Takahashi ◽  
Akihide Ohkuchi ◽  
Chikako Hirashima ◽  
Shigeki Matsubara ◽  
Mitsuaki Suzuki
Keyword(s):  
Reference Values ◽  
Pulsatility Index ◽  
Uterine Artery ◽  
Resistance Index ◽  
Notch Depth ◽  
Depth Index

scholarly journals Role of uterine artery doppler at 18-22 weeks in the prediction of pre-eclampsia: a prospective study

2020 ◽  
Vol 9 (10) ◽  
pp. 4130
Author(s):  
Lakshmi Manjeera M. ◽  
Patricia Malini Pereira
Keyword(s):  
Positive Predictive Value ◽  
Negative Predictive Value ◽  
Predictive Value ◽  
Pulsatility Index ◽  
Uterine Artery ◽  
Resistance Index ◽  
Early Screening ◽  
Predictive Values ◽  
Uterine Artery Doppler ◽  
Doppler Study

Background: Pre-eclampsia is the most common pregnancy complication associated with serious maternal and fetal morbidity. Uterine artery Doppler reflects the impaired trophoblastic invasion of the uterine spiral arteries, which is involved in the aetiology of preeclampsia. Thus, uterine artery Doppler was proposed as a screening test for pre-eclampsia.Methods: A prospective cohort study of 100 singleton pregnancies was conducted in a tertiary centre and the study population were subjected to uterine artery Doppler study at 18-22 weeks gestation. Uterine artery Doppler indices of pulsatility index (PI), resistance index (RI) and persistence of diastolic notch was obtained and the outcome of pre-eclampsia was studied.Results: Out of 100 women, 14 women developed pre-eclampsia in which the resistance index showed a sensitivity of 21.4%, specificity of 91.8%, positive predictive value of 30% and negative predictive value of 87.7% and pulsatility index showed sensitivity of 35.7%, specificity of 90.6%, positive predictive value of 38.4% and negative predictive value of 89.6%. Diastolic notch had a sensitivity of 35.7%, specificity of 98.8%, positive predictive value of 83.3% and a negative predictive value of 90.4%.Conclusions: The high negative predictive values, indicated that women with normal Doppler velocimetry were unlikely to develop preeclampsia. Uterine artery Doppler, being non-invasive can be included during routine sonography to identify patients at risk of developing pre-eclampsia. Early, screening for pre-eclampsia will help in individualized antenatal surveillance and initiation of prophylactic therapy, early to reduce the adverse maternal and foetal complications of preeclampsia.

Effect of the loading dose of magnesium sulfate on the Doppler velocimetry parameters in the uterine, umbilical and fetal middle cerebral arteries in severe preeclampsia

QJM ◽  
2021 ◽  
Vol 114 (Supplement_1) ◽  
Author(s):  
Mohamed A ElKady ◽  
Noha H Rabie ◽  
Mohammed H Mostafa ◽  
Amany M Hafez
Keyword(s):  
Blood Flow ◽  
Magnesium Sulfate ◽  
Pulsatility Index ◽  
Uterine Artery ◽  
Cerebral Arteries ◽  
Resistance Index ◽  
Severe Preeclampsia ◽  
Loading Dose ◽  
Doppler Velocimetry ◽  
Middle Cerebral Arteries

Abstract Background Preeclampsia is pregnancy-specific syndrome of reduced organ perfusion secondary to vasospasm and endothelial activation. Aim of the Work to assess the effect of injecting magnesium sulfate on Doppler parameters of uterine artery, umbilical and fetal middle cerebral arteries (MCA) in women with severe preeclampsia. Patients and Methods This study included eighty pregnant with severe preeclampsia or eclampsia who were given magnesium sulphate therapy in Ain Shams University Maternity hospital. The Study group included 80 pregnant patients Doppler flow velocity parameters (resistance index [RI], pulsatility index [PI] and systolic/diastolic [S/D] ratio) were evaluated in the uterine, fetal umbilical and middle cerebral arteries before and 20 minutes after intravenous administration of 6 grams of magnesium sulfate (Loading dose). Results Magnesium sulfate had significant hemodynamic effects with significant reduction of systolic and diastolic blood pressure. Regarding the Doppler studies, it was found that after administration of magnesium sulfate there was significant reduction in the Doppler velocimetry parameters (Resistance index[RI], Pulsatility index[PI] and systolic/diastolic[S/D] ratio) in the uterine, umbilical and fetal middle cerebral arteries denoting decreased vascular resistance with increased blood flow in these vessels. Conclusion Intravenous administration of magnesium sulfate in pregnant women with severe preeclampsia and eclampsia resulted in a decrease in uterine artery, fetal umbilical and middle cerebral arteries Doppler indices with reduced resistance to blood flow in these vessels.

scholarly journals Effects of the Selective Progesterone Receptor Modulator Asoprisnil on Uterine Artery Blood Flow, Ovarian Activity, and Clinical Symptoms in Patients with Uterine Leiomyomata Scheduled for Hysterectomy

2008 ◽  
Vol 93 (12) ◽  
pp. 4664-4671 ◽  
Author(s):  
Julia Wilkens ◽  
Kristof Chwalisz ◽  
Cong Han ◽  
Jane Walker ◽  
Iain T. Cameron ◽  
...  
Keyword(s):  
Blood Flow ◽  
Progesterone Receptor ◽  
Pulsatility Index ◽  
Uterine Artery ◽  
Resistance Index ◽  
Controlled Study ◽  
Clinical Effects ◽  
Artery Blood Flow ◽  
Uterine Leiomyomata ◽  
Receptor Modulator

Introduction: Asoprisnil, a novel orally active selective progesterone receptor modulator, is being studied for the management of symptomatic uterine leiomyomata. The exact mechanism of action is not yet discerned. The primary objectives of this double-blind, randomized, placebo-controlled study included evaluation of the effect of asoprisnil on uterine artery blood flow. Furthermore, we assessed effects of asoprisnil on leiomyoma symptoms. Patients and Methods: Thirty-three premenopausal patients scheduled for hysterectomy due to symptomatic uterine leiomyomata were recruited in four centers and treated with 10 or 25 mg asoprisnil or placebo for 12 wk before surgery. At baseline and before hysterectomy, all patients underwent sonographic assessment to measure impedance to uterine artery blood flow, determined by resistance index and pulsatility index, as well as volumes of largest leiomyoma and uterus. In addition, patients recorded intensity and frequency of menstrual bleeding on a menstrual pictogram. Each asoprisnil treatment was compared with placebo. Results: The increased pulsatility index in both asoprisnil groups and the statistically significantly increased resistance index within the 25-mg asoprisnil group suggest a moderately decreased uterine artery blood flow. Analysis of menstrual pictogram scores showed a statistically significant larger decrease in frequency and intensity of bleeding for both asoprisnil groups compared with placebo. Bleeding was suppressed by asoprisnil 25mg in 91% of patients. Asoprisnil treatment was well tolerated when administered daily for a 12-wk period, and no serious adverse events occurred. Conclusion: Asoprisnil moderately reduced uterine artery blood flow. This effect may contribute in part to the clinical effects of asoprisnil.

scholarly journals Uterine artery pulsatility index as a relevant parameter in the prediction of preeclampsia

2020 ◽  
Vol 66 (1) ◽  
pp. 65-71
Author(s):  
Maja Pejkovska Ilieva ◽  
Vesna Antovska ◽  
Mirjana Kaeva Pejkovska
Keyword(s):  
Predictive Value ◽  
Pulsatility Index ◽  
Uterine Artery ◽  
Resistance Index ◽  
Clinical Syndrome ◽  
Control Group ◽  
Study Group ◽  
Relevant Parameter ◽  
Gynecology And Obstetrics ◽  
Reliable Parameter

Preeclampsia is a clinical syndrome that occurs in 5-10% of pregnancies with increased perinatal morbidity and mortality. According to ISUOG (International Society of Ultrasound in Obstetrics & Gynecology), the use of the uterine artery pulsatility index (PI) is an important sensitive method in predicting the risk of preeclampsia. This study is to emphasize the value of PI as a more relevant predictive parameter in the detection of preeclampsia in the second trimester compared to the presence of isolated uterine artery notch. For the above purpose, 96 patients were examined at the University Clinic of Gynecology and Obstetrics in Skopje, divided into 2 groups: study and control group. The study group consisted of 48 patients from 14 to 20 gestational weeks with present uterine artery notch, being the main inclusion criterion. The control group consisted of 48 pregnant patients at the same gestational age with absence of uterine artery notch. In the study group, 43.7% developed clinical syndrome of preeclampsia. The resistance index (RI) value was up to 0.73 and the predictive value of the RI was 57.1%. In patients who developed preeclampsia syndrome, the value of the PI above 1.75 was of much greater predictive value, with value of 71.4%. The sensitivity of these values was 88%, which is a reliable parameter. PI is a reliable parameter in detecting the risk of developing preeclampsia and an indicator of great clinical significance in the daily practice in perinatology. Keywords: preeclampsia; prediction; pulsatility index

Reference values for pulsatility index of fetal anterior and posterior cerebral arteries in prolonged pregnancy

2021 ◽  
Author(s):  
Paolo Rosati ◽  
Silvia Buongiorno ◽  
Silvia Salvi ◽  
Antonio Lanzone ◽  
Alessandra Familiari
Keyword(s):  
Reference Values ◽  
Pulsatility Index ◽  
Cerebral Arteries ◽  
Prolonged Pregnancy

Increased pulsatility index of uterine artery Doppler between 26 and 28 weeks of gestation and adverse perinatal outcomes

2021 ◽  
pp. 1-8
Author(s):  
Daniela Rocha Ramos ◽  
Edward Araujo Júnior ◽  
Caetano Galvão Petrini ◽  
Fernando Felix Dulgheroff ◽  
Taciana Mara Rodrigues da Cunha Caldas ◽  
...  
Keyword(s):  
Pulsatility Index ◽  
Uterine Artery ◽  
Perinatal Outcomes ◽  
Uterine Artery Doppler ◽  
Adverse Perinatal Outcomes
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