Phosphodiesterase type IV inhibition prevents sequestration of CREB binding protein, protects striatal parvalbumin interneurons and rescues motor deficits in the R6/2 mouse model of Huntington’s disease

2009 ◽  
Vol 29 (5) ◽  
pp. 902-910 ◽  
Author(s):  
Carmela Giampà ◽  
Silvia Middei ◽  
Stefano Patassini ◽  
Antonella Borreca ◽  
Fabrizia Marullo ◽  
...  
Keyword(s):  
Mouse Model ◽  
Huntington's Disease ◽  
Huntington’S Disease ◽  
Binding Protein ◽  
Motor Deficits ◽  
Creb Binding Protein ◽  
Type Iv ◽  
Parvalbumin Interneurons ◽  
Phosphodiesterase Type

scholarly journals CRISPR-Cas9-Mediated Genome Editing Increases Lifespan and Improves Motor Deficits in a Huntington’s Disease Mouse Model

2019 ◽  
Vol 17 ◽  
pp. 829-839 ◽  
Author(s):  
Freja K. Ekman ◽  
David S. Ojala ◽  
Maroof M. Adil ◽  
Paola A. Lopez ◽  
David V. Schaffer ◽  
...  
Keyword(s):  
Mouse Model ◽  
Huntington's Disease ◽  
Huntington’S Disease ◽  
Genome Editing ◽  
Motor Deficits

scholarly journals Exercise attenuates neuropathology and has greater benefit on cognitive than motor deficits in the R6/1 Huntington's disease mouse model

2013 ◽  
Vol 248 ◽  
pp. 457-469 ◽  
Author(s):  
David J. Harrison ◽  
Monica Busse ◽  
Rebecca Openshaw ◽  
Anne E. Rosser ◽  
Stephen B. Dunnett ◽  
...  
Keyword(s):  
Mouse Model ◽  
Huntington's Disease ◽  
Huntington’S Disease ◽  
Motor Deficits

scholarly journals Conditioned medium from amniotic cells protects striatal degeneration and ameliorates motor deficits in the R6/2 mouse model of Huntington's disease

2018 ◽  
Vol 23 (2) ◽  
pp. 1581-1592 ◽  
Author(s):  
Carmela Giampà ◽  
Alessandra Alvino ◽  
Marta Magatti ◽  
Antonietta R. Silini ◽  
Antonella Cardinale ◽  
...  
Keyword(s):  
Mouse Model ◽  
Huntington's Disease ◽  
Huntington’S Disease ◽  
Conditioned Medium ◽  
Motor Deficits ◽  
Striatal Degeneration ◽  
Amniotic Cells

Prostaglandin E2 EP1 Receptor Antagonist Improves Motor Deficits and Rescues Memory Decline in R6/1 Mouse Model of Huntington's Disease

2013 ◽  
Vol 49 (2) ◽  
pp. 784-795 ◽  
Author(s):  
Marta Anglada-Huguet ◽  
Xavier Xifró ◽  
Albert Giralt ◽  
Alfonsa Zamora-Moratalla ◽  
Eduardo D Martín ◽  
...  
Keyword(s):  
Mouse Model ◽  
Prostaglandin E2 ◽  
Huntington's Disease ◽  
Receptor Antagonist ◽  
Huntington’S Disease ◽  
Motor Deficits ◽  
Memory Decline ◽  
Ep1 Receptor
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