scholarly journals Early white matter abnormalities, progressive brain pathology and motor deficits in a novel knock-in mouse model of Huntington's disease

2015 ◽  
Vol 24 (9) ◽  
pp. 2508-2527 ◽  
Author(s):  
Jing Jin ◽  
Qi Peng ◽  
Zhipeng Hou ◽  
Mali Jiang ◽  
Xin Wang ◽  
...  
Keyword(s):  
White Matter ◽  
Mouse Model ◽  
Huntington's Disease ◽  
Huntington’S Disease ◽  
Motor Deficits ◽  
Brain Pathology ◽  
White Matter Abnormalities

scholarly journals CRISPR-Cas9-Mediated Genome Editing Increases Lifespan and Improves Motor Deficits in a Huntington’s Disease Mouse Model

2019 ◽  
Vol 17 ◽  
pp. 829-839 ◽  
Author(s):  
Freja K. Ekman ◽  
David S. Ojala ◽  
Maroof M. Adil ◽  
Paola A. Lopez ◽  
David V. Schaffer ◽  
...  
Keyword(s):  
Mouse Model ◽  
Huntington's Disease ◽  
Huntington’S Disease ◽  
Genome Editing ◽  
Motor Deficits

scholarly journals Correlations of Behavioral Deficits with Brain Pathology Assessed through Longitudinal MRI and Histopathology in the R6/1 Mouse Model of Huntington’s Disease

PLoS ONE ◽  
2013 ◽  
Vol 8 (12) ◽  
pp. e84726 ◽  
Author(s):  
Ivan Rattray ◽  
Edward J. Smith ◽  
William R. Crum ◽  
Thomas A. Walker ◽  
Richard Gale ◽  
...  
Keyword(s):  
Mouse Model ◽  
Huntington's Disease ◽  
Huntington’S Disease ◽  
Brain Pathology ◽  
Behavioral Deficits ◽  
Longitudinal Mri

scholarly journals Exercise attenuates neuropathology and has greater benefit on cognitive than motor deficits in the R6/1 Huntington's disease mouse model

2013 ◽  
Vol 248 ◽  
pp. 457-469 ◽  
Author(s):  
David J. Harrison ◽  
Monica Busse ◽  
Rebecca Openshaw ◽  
Anne E. Rosser ◽  
Stephen B. Dunnett ◽  
...  
Keyword(s):  
Mouse Model ◽  
Huntington's Disease ◽  
Huntington’S Disease ◽  
Motor Deficits
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