Paraventricular hypothalamic oxytocinergic cells responding to noxious stimulation and projecting to the spinal dorsal horn represent a homeostatic analgesic mechanism

2009 ◽  
Vol 30 (6) ◽  
pp. 1056-1063 ◽  
Author(s):  
Miguel Condés-Lara ◽  
Gerardo Rojas-Piloni ◽  
Guadalupe Martínez-Lorenzana ◽  
Javier Rodríguez-Jiménez
Keyword(s):  
Dorsal Horn ◽  
Spinal Dorsal Horn ◽  
Noxious Stimulation ◽  
Spinal Dorsal ◽  
Oxytocinergic Cells

PAG-microinjected dipyrone (metamizol) inhibits responses of spinal dorsal horn neurons to natural noxious stimulation in rats

1997 ◽  
Vol 759 (1) ◽  
pp. 171-174 ◽  
Author(s):  
Horacio Vanegas ◽  
Vı́ctor Tortorici ◽  
Antonio Eblen-Zajjur ◽  
Enrique Vásquez
Keyword(s):  
Dorsal Horn ◽  
Spinal Dorsal Horn ◽  
Noxious Stimulation ◽  
Dorsal Horn Neurons ◽  
Spinal Dorsal ◽  
Spinal Dorsal Horn Neurons

scholarly journals Phosphorylation of ERK in Neurokinin 1 Receptor-Expressing Neurons in Laminae III and IV of the Rat Spinal Dorsal Horn Following Noxious Stimulation

2007 ◽  
Vol 3 ◽  
pp. 1744-8069-3-4 ◽  
Author(s):  
Erika Polgár ◽  
Annie D Campbell ◽  
Lynsey M MacIntyre ◽  
Masahiko Watanabe ◽  
Andrew J Todd
Keyword(s):  
Dorsal Horn ◽  
Spinal Dorsal Horn ◽  
Noxious Stimulation ◽  
Neurokinin 1 Receptor ◽  
Spinal Dorsal ◽  
Neurokinin 1

Roles of CaMKII, PKA, and PKC in the Induction and Maintenance of LTP of C-Fiber-Evoked Field Potentials in Rat Spinal Dorsal Horn

2004 ◽  
Vol 91 (3) ◽  
pp. 1122-1133 ◽  
Author(s):  
Hong-Wei Yang ◽  
Xiao-Dong Hu ◽  
Hong-Mei Zhang ◽  
Wen-Jun Xin ◽  
Ming-Tao Li ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Dorsal Horn ◽  
Spinal Dorsal Horn ◽  
Long Term Potentiation ◽  
Noxious Stimulation ◽  
Tetanic Stimulation ◽  
Field Potentials ◽  
Spinal Dorsal ◽  
Evoked Field Potentials ◽  
C Fiber

Long-term potentiation (LTP) of C-fiber-evoked field potentials in spinal dorsal horn may be relevant to hyperalgesia, an increased response to noxious stimulation. The mechanism underlying this form of synaptic plasticity is, however, still unclear. Considerable evidence has shown that calcium/calmodulin-dependent protein kinase II (CaMKII), protein kinase A (PKA), and protein kinase C (PKC) are important for LTP in hippocampus. In this study, the roles of these three protein kinases in the induction and maintenance of LTP of C-fiber-evoked field potentials were evaluated by application of specific inhibitors of CaMKII (KN-93 and AIP), PKA (Rp-CPT-cAMPS), and PKC (chelerythrine and Gö 6983) at the recording segments before and after LTP induction in urethane-anesthetized Sprague-Dawley rats. We found both KN-93 and AIP, when applied at 30 min prior to tetanic stimulation, completely blocked LTP induction. At 30 min after LTP induction, KN-93 and AIP reversed LTP completely, and at 60 min after LTP induction, they depressed spinal LTP in most rats tested. Three hours after LTP induction, however, KN-93 or AIP did not affect the spinal LTP. Rp-CPT-cAMPS, chelerythrine, and Gö 6983 blocked the spinal LTP when applied at 30 min before tetanic stimulation and reversed LTP completely at 15 min after LTP induction. In contrast, at 30 min after LTP induction, the drugs never affected the spinal LTP. These results suggest that activation of CaMKII, PKA, and PKC may be crucial for the induction and the early-phase but not for the late-phase maintenance of the spinal LTP.

Noxious stimulation decreases substance P binding in rat spinal dorsal horn

Neuroreport ◽  
1994 ◽  
Vol 5 (16) ◽  
pp. 2101-2104 ◽  
Author(s):  
K. Yashpal ◽  
S. Kar ◽  
R. Quirion ◽  
C. W. Y. Hui-Chan ◽  
J. L. Henry
Keyword(s):  
Substance P ◽  
Dorsal Horn ◽  
Spinal Dorsal Horn ◽  
Noxious Stimulation ◽  
Spinal Dorsal

Effect of Propofol on Spinal Dorsal Horn Neurons: Comparison with Lack of Ketamine Effects

1995 ◽  
Vol 83 (6) ◽  
pp. 1312-1320 ◽  
Author(s):  
Hiroshi Uchida ◽  
Kazuhiro Kishikawa ◽  
J. G. Collins
Keyword(s):  
Receptive Field ◽  
Dorsal Horn ◽  
Sensory Processing ◽  
Spinal Dorsal Horn ◽  
Noxious Stimulation ◽  
General Anesthetics ◽  
Dorsal Horn Neurons ◽  
Spinal Dorsal ◽  
Low Threshold ◽  
Spinal Dorsal Horn Neurons

Abstract Background Pentobarbital reduces low-threshold receptive field (RF) size and enhances responses of some spinal dorsal horn neurons to noxious stimulation in cats. To better understand the effects of general anesthetics on spinal sensory processing, this study was designed to determine if intravenous propofol and ketamine have similar effects.

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