RetractedGeographical variation in cloacal microflora and bacterial antibiotic resistance in a threatened avian scavenger in relation to diet and livestock farming practices

Industrial food animal production uses huge amounts of antibiotics worldwide. Livestock, their excreta used for manure and meat subproducts not intended for human consumption can all play important roles in the transmission of bacterial resistance to wildlife. Vultures and other scavengers can be directly exposed to active antibiotics ingested while feeding on livestock carcasses. This study evaluates whether bacterial resistance in the red kite (Milvus milvus) differs between two wintering areas selected based on patent differences in farming practices—particularly in the industrial production of food animals (primarily swine and poultry) vs. scarce and declining sheep herding. The results support the hypothesis that intensification in food animal production is associated with increased bacterial multidrug resistance in wildlife. Resistance was positively correlated with time elapsed since the beginning of the commercial application of each antibiotic in human and veterinary medicine, with clear differences depending on farming intensification between areas. Monitoring programs are encouraged to use red kites and other avian scavengers as valuable sentinels of contamination by antibiotics and clinically relevant resistant pathogens from livestock operations of variable intensities. Farms authorized for supplementary feeding of threatened scavengers should avoid supplying carcasses with active antibiotic residues to avoid bacterial resistance in scavenger wildlife.

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Phenotypic delay in the evolution of bacterial antibiotic resistance: Mechanistic models and their implications

PLoS Computational Biology ◽

10.1371/journal.pcbi.1007930 ◽

2020 ◽

Vol 16 (5) ◽

pp. e1007930

Author(s):

Martín Carballo-Pacheco ◽

Michael D. Nicholson ◽

Elin E. Lilja ◽

Rosalind J. Allen ◽

Bartlomiej Waclaw

Keyword(s):

Antibiotic Resistance ◽

Mechanistic Models ◽

Bacterial Antibiotic Resistance

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Bacterial Antibiotic Resistance: on the Cusp of a Post-antibiotic World

Current Treatment Options in Infectious Diseases ◽

10.1007/s40506-019-0181-4 ◽

2019 ◽

Vol 11 (1) ◽

pp. 42-57

Author(s):

Kameron Sprigg ◽

Carolynn E. Pietrangeli

Keyword(s):

Antibiotic Resistance ◽

Bacterial Antibiotic Resistance

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Photodegradation of Antibiotics by Noncovalent Porphyrin-Functionalized TiO2 in Water for the Bacterial Antibiotic Resistance Risk Management

International Journal of Molecular Sciences ◽

10.3390/ijms21113775 ◽

2020 ◽

Vol 21 (11) ◽

pp. 3775 ◽

Cited By ~ 1

Author(s):

Massimiliano Gaeta ◽

Giuseppe Sanfilippo ◽

Aurore Fraix ◽

Giuseppe Sortino ◽

Matteo Barcellona ◽

...

Keyword(s):

Public Health ◽

Water Pollution ◽

Bacterial Infections ◽

Solar Irradiation ◽

Livestock Farming ◽

Covalent Functionalization ◽

Innovative Strategies ◽

Resistance Risk ◽

Bacterial Antibiotic Resistance ◽

Simulated Solar Irradiation

Antibiotics represent essential drugs to contrast the insurgence of bacterial infections in humans and animals. Their extensive use in livestock farming, including aquaculture, has improved production performances and food safety. However, their overuse can implicate a risk of water pollution and related antimicrobial resistance. Consequently, innovative strategies for successfully removing antibiotic contaminants have to be advanced to protect human health. Among them, photodegradation TiO2-driven under solar irradiation appears not only as a promising method, but also a sustainable pathway. Hence, we evaluated several composite TiO2 powders with H2TCPP, CuTCPP, ZnTCPP, and SnT4 porphyrin for this scope in order to explore the effect of porphyrins sensitization on titanium dioxide. The synthesis was realized through a fully non-covalent functionalization in water at room conditions. The efficacy of obtained composite materials was also tested in photodegrading oxolinic acid and oxytetracycline in aqueous solution at micromolar concentrations. Under simulated solar irradiation, TiO2 functionalized with CuTCPP has shown encouraging results in the removal of oxytetracycline from water, by opening the way as new approaches to struggle against antibiotic’s pollution and, finally, to represent a new valuable tool of public health.

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