Intradermal injection of methylene blue for the treatment of refractory pruritus ani

2009 ◽  
Vol 11 (3) ◽  
pp. 282-287 ◽  
Author(s):  
A. D. Sutherland ◽  
I. G. Faragher ◽  
F. A. Frizelle
2021 ◽  
Vol 30 (Sup9a) ◽  
pp. VIIIi-VIIIx
Author(s):  
Vinícius FM Beldi ◽  
Marina J Rosique ◽  
Luis Fernando Tirapelli ◽  
Eny KU Moriguti ◽  
Altacílio A Nunes ◽  
...  

Objective: A burn injury has two defined areas: central necrosis and an adjacent area of ischaemia, which may or may not progress to necrosis. The concentration of nitric oxide (NO) increases after burn injury and may originate from potent oxidising agents. Methylene blue (MB) may act as an antioxidant and is supposed to reduce burn progression. This investigation was carried out to evaluate the effects of intradermal MB on necrosis progression in burns. Methods: Full-thickness burn injuries were performed by applying a heated metal comb on the shaved back of male Wistar rats. The animals were divided into three groups: Control (C, n=7); MB (2mg/kg) one hour after burn injury (MB1h, n=11); and MB (2mg/kg) six hours after burn injury (MB6h, n=8). After seven days the lesions were photographed for visual assessment of burn necrosis; full-thickness cuts of lesions were dyed with Masson and Giemsa for microscopic histopathology; and tissue fragments of unburned interspaces were processed for chemiluminescence with nitrite/nitrate (NOX) and malondialdehyde (MDA) as oxidative stress markers. Results: No statistically significant differences between groups were observed during visual analysis and NOX dosage. However, in microscopic analysis, the MB1h and MB6h groups showed smaller areas of necrosis, less inflammatory infiltration, and a more significant extension of interspaces. Furthermore, the dosage of MDA revealed that the MB1h group showed lower values when compared with the control group (p=0.001). Conclusions: The study provided good evidence that MB intradermal injection can reduce necrosis progression in ischaemic perilesional areas and suggests an alternative to treating burns.


2004 ◽  
Vol 8 (1) ◽  
pp. 11-14 ◽  
Author(s):  
B. B. Mentes ◽  
M. Akin ◽  
S. Leventoglu ◽  
F. A. Gultekin ◽  
M. Oguz
Keyword(s):  

2021 ◽  
Vol 31 (1) ◽  
pp. 84-85
Author(s):  
Ahmet Topçu ◽  
Muhammed Kadir Yıldırak ◽  
İlknur Turan ◽  
Abdullah Yıldız ◽  
Miraç İlker Pala

2020 ◽  
Vol 22 (7) ◽  
pp. 846-847
Author(s):  
N. E. Samalavicius ◽  
V. Klimasauskiene ◽  
A. Dulskas

2005 ◽  
Vol 3 (3) ◽  
pp. 0-0
Author(s):  
Narimantas Evaldas Samalavičius ◽  
Tomas Poškus ◽  
Alfredas Kilius

Narimantas Evaldas Samalavičius1, Tomas Poškus2, Alfredas Kilius11 Vilniaus universiteto Onkologijos instituto Chirurgijos klinika,Santariškių g. 1, LT-08660 Vilnius2 Vilniaus universiteto ligoninės Santariškių klinikosCentro filialo III abdominalinės chirurgijos skyriausKoloproktologijos poskyris,Žygimantų g. 3, LT-01102 VilniusEl paštas: [email protected] Tikslas Įvertinti pirmuosius rezultatus gydant išangės niežulį 1% metileno mėlio tirpalo injekcija į išangės srities odą. Ligoniai ir metodai Per 11 mėnesių, nuo 2004 m. rugsėjo iki 2005 m. rugpjūčio, nuo išangės niežulio 1% metileno mėlio tirpalo injekcija į išangės srities odą gydyti 6 ligoniai: 4 moterys ir 2 vyrai, kurių amžius nuo 29 iki 62 metų, vidurkis 50 metų. Viena procedūra atlikta ambulatoriškai ir penkios – stacionaro sąlygomis, hospitalizacijos trukmė nuo 1 iki 5 parų, vidutiniškai 2,6 paros. Išangės niežuliu iki šios procedūros ligoniai skundėsi nuo 6 mėnesių iki 4 metų. Rezultatai Komplikacijų po šių procedūrų nebuvo, niežulys išnyko visiems. Išangės paburkimas vidutiniškai buvo iki 8 savaičių, odos nejautrumas – 3–4 savaites. Visi ligoniai apklausti po 12 savaičių. Išvada Vieno procento metileno mėlio injekcija į išangės srities odą yra saugus ir veiksmingas metodas idiopatiniam išangės niežuliui gydyti. Reikšminiai žodžiai: išangės niežulys, metileno mėlis. Methylene blue injection into perianal skin for idiopathic pruritus ani Narimantas Evaldas Samalavičius1, Tomas Poškus2, Alfredas Kilius11 Vilnius University, Institute of Oncology, Clinic of Surgery,Santariškių str. 1, LT-08660 Vilnius, Lithuania2 Vilnius University Hospital "Santariškių klinikos", Central Branch,3rd Department of Abdominal Surgery, Division of Coloproctology,Žygimantų str. 3, LT-01102 Vilnius, LithuaniaE-mail: [email protected] Objective To evaluate our first experience with 1% methylene blue injection into perianal skin for idiopathic pruritus ani. Patients and methods Over a period of 11 months (September 2004 to August 2005), a total of six patients (4 women and 2 men, age range 29 to 64 years, mean 50 years) were treated with 1% methylene blue injection into perianal skin for idiopathic pruritus ani. One procedure was made on an outpatient setting, the rest five were performed during in-hospital stay. The average hospital stay was 2.6 days (range 1 to 5 days). Symptoms had been present 6 months to 4 years prior to our treatment. Results There were no complications, all patients were symptom-free at 12 weeks after the procedure. Edema of the perianal region was present on an average for 8 weeks, and numbness in the perianal skin was present for 3–4 weeks. Conclusion 1% methylene blue injection into perianal skin in our experience was a safe and effective method for the treatment of idiopathic pruritus ani. Keywords: pruritus ani, methylene blue


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