THE RELATIONSHIP OF METASTATIC ACTIVITY TO PRIMARY TUMOR SIZE WITH SPECIAL REFERENCE TO BREAST CANCER

1979 ◽  
Vol 21 (1) ◽  
pp. 1-17 ◽  
Author(s):  
G. M. Tallis ◽  
P. Leppard ◽  
T. J. O'Neill ◽  
G. Sarfaty
Keyword(s):  
Breast Cancer ◽  
Special Reference ◽  
Tumor Size ◽  
Primary Tumor ◽  
Primary Tumor Size ◽  
Metastatic Activity ◽  
Relationship Of ◽  
The Relationship

Identification of a subgroup of patients with breast cancer and histologically positive axillary nodes receiving adjuvant chemotherapy who may benefit from postoperative radiotherapy.

1988 ◽  
Vol 6 (7) ◽  
pp. 1107-1117 ◽  
Author(s):  
B Fowble ◽  
R Gray ◽  
K Gilchrist ◽  
R L Goodman ◽  
S Taylor ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Adjuvant Chemotherapy ◽  
Tumor Size ◽  
Primary Tumor ◽  
Postoperative Radiotherapy ◽  
Eastern Cooperative Oncology Group ◽  
Distant Metastases ◽  
Primary Tumor Size ◽  
Axillary Nodes ◽  
Postmastectomy Radiation

Risk factors for isolated local-regional (LR) recurrence following mastectomy for breast cancer were analyzed in a review of 627 women entered into Eastern Cooperative Oncology Group (ECOG) adjuvant chemotherapy trials between 1978 and 1982. Premenopausal patients were randomized to cyclophosphamide, methotrexate, and fluorouracil (5-FU) (CMF), cyclophosphamide, methotrexate, 5-FU, and prednisone (CMFP), or cyclophosphamide, methotrexate, 5-FU, prednisone, and tamoxifen (CMFPT). Postmenopausal patients were randomized to observation, CMFP, or CMFPT. Median follow-up time was 4.5 years. At 3 years, 225 patients relapsed and in 70 (31% of failures, 11% of all patients) the initial site was LR without distant metastases. In a multivariate analysis, the risk of an isolated LR recurrence significantly correlated with the number of positive axillary nodes, the primary tumor size, the presence of tumor necrosis, and the number of axillary nodes examined. Factors that significantly discriminated between an isolated LR recurrence and distant metastasis were the number of positive nodes and primary tumor size. Patients with four to seven positive nodes or tumor size greater than or equal to 5 cm had a chance of developing an isolated LR recurrence almost equal to the risk of distant metastases. These findings suggest a potential for improved survival in this subset of patients with the addition of postmastectomy radiation to chemotherapy, and continue to emphasize the presence of a group of patients at high risk for isolated LR recurrence despite adjuvant chemotherapy.

scholarly journals The Numbers of FoxP3+ Lymphocytes in Sentinel Lymph Nodes of Breast Cancer Patients Correlate With Primary Tumor Size but Not Nodal Status

2011 ◽  
Vol 29 (6) ◽  
pp. 419-425 ◽  
Author(s):  
Raavi Gupta ◽  
James S. Babb ◽  
Baljit Singh ◽  
Luis Chiriboga ◽  
Leonard Liebes ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Lymph Nodes ◽  
Cancer Patients ◽  
Tumor Size ◽  
Primary Tumor ◽  
Sentinel Lymph Nodes ◽  
Nodal Status ◽  
Breast Cancer Patients ◽  
Primary Tumor Size

A nomogram to predict nonsentinel lymph node involvement in breast cancer patients with sentinel lymph node metastases.

2011 ◽  
Vol 29 (27_suppl) ◽  
pp. 14-14
Author(s):  
Y. Kojima ◽  
K. Tsugawa ◽  
K. Enokido ◽  
H. Iwata ◽  
S. Ohno ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Multivariate Analysis ◽  
Lymph Node ◽  
Cancer Patients ◽  
Predictive Factors ◽  
Tumor Size ◽  
Primary Tumor ◽  
Lymphatic Invasion ◽  
Breast Cancer Patients ◽  
Primary Tumor Size

14 Background: Several nomograms have been described as predictors of non-sentinel axially lymph node (non-SN) metastases in breast cancer with positive sentinel nodes (SN). However, all these predicting models were based on data from western countries. The purpose of this study was to examine predictive factors of non-SN status among SN metastatic patients, in order to develop a nomogram based on Japanese large data set. Methods: This research was analyzed by using a clinical database of 11,228 Japanese breast cancer patients who registerd to cohort study as SN biopsy between March 2008 and Octover 2009 in Japan. We reviewed data retrospectively to extract patients with SN metastases who underwent complementary axillary lymph node dissection. In this cohort, we examined predictive factors of non-SN metastases. All clinical and pathologic features were analyzed to predict the non-SN status, by using univariate and multivariate logistic regression model. A receiver operating characteristic curve was constructed and the area under the curve (AUC) was calculated. Results: Among the database, SN metastases were found in 1,029 patients, and 345 (33.5%) were non-SN positive. Univariate analysis showed a significant association between non-SN involvement and primary tumor size (p<0.001), histologic grade (p=0.011), lymphatic invasion (p<0.001), venous invasion (p=0.005) and the number of involved SNs among all identified SNs (p<0.001). Tumor size (p<0.001), lymphatic invasion (p<0.001), and the size of SN metastasis (p<0.001) were associated with non-SN metastasis in multivariate analysis. Based on the multivariate analysis, we developed a scoring system to predict the likelihood of non-SN metastases in breast cancer patients with SN involvement. The discriminatory ability of our nomogram, as measured by the AUC, was 0.752. Conclusions: In patients with invasive breast cancer and a positive SN, primary tumor size, lymphatic invasion, and the size of SN metastases among all identified SNs were independently predictive of non-SN involvement, and used for a nomogram. Validation study will be performed in the future investigation.

scholarly journals ВОЗМОЖНОСТИ РЕНТГЕНОВСКОЙ МАММОГРАФИИ "МАЛЫХ" ФОРМ РАКА МОЛОЧНОЙ ЖЕЛЕЗЫ НА ФОНЕ ФИБРОЗНО-КИСТОЗНОЙ БОЛЕЗНИ

2014 ◽  
Vol 13 (1) ◽  
pp. 27-30
Author(s):  
D. G. Bukharin ◽  
S. A. Velichko ◽  
I. G. Frolova
Keyword(s):  
Breast Cancer ◽  
Tumor Size ◽  
Primary Tumor ◽  
Conventional Approach ◽  
Diagnostic Process ◽  
Breast Lesions ◽  
Concomitant Disease ◽  
Fibrocystic Disease ◽  
Cancer Symptoms ◽  
Primary Tumor Size

The analysis of radiologic signs of small size breast cancer in patients with fibrocystic disease has been carried out.The conventional approach to the analysis of mammograms of these patients based on the detection of primary, secondary and indirect cancer symptoms has been found to have insufficient effect.The relationship between mammographic findings and primary tumor size, character and concomitant disease intensity has been proved.The data obtained allow us to arrange the diagnostic process and management of patients with breast lesions.

Axillary Lymph Nodes: US-guided Fine-Needle Aspiration for Initial Staging of Breast Cancer—Correlation with Primary Tumor Size

Radiology ◽  
2008 ◽  
Vol 246 (1) ◽  
pp. 81-89 ◽  
Author(s):  
Susan L. Koelliker ◽  
Maureen A. Chung ◽  
Martha B. Mainiero ◽  
Margaret M. Steinhoff ◽  
Blake Cady
Keyword(s):  
Breast Cancer ◽  
Fine Needle Aspiration ◽  
Tumor Size ◽  
Primary Tumor ◽  
Needle Aspiration ◽  
Axillary Lymph Nodes ◽  
Axillary Lymph ◽  
Primary Tumor Size ◽  
Fine Needle ◽  
Initial Staging

Sentinel Lymph Node Biopsy With Metastasis: Can Axillary Dissection Be Avoided in Some Patients With Breast Cancer?

1999 ◽  
Vol 17 (6) ◽  
pp. 1720-1720 ◽  
Author(s):  
Carol Reynolds ◽  
Rosemarie Mick ◽  
John H. Donohue ◽  
Clive S. Grant ◽  
David R. Farley ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Tumor Size ◽  
Primary Tumor ◽  
Axillary Dissection ◽  
Metastatic Breast ◽  
Axillary Lymph ◽  
Primary Tumors ◽  
Primary Tumor Size

PURPOSE: Recent studies have suggested that the sentinel lymph node (SLN) biopsy is an accurate alternative staging procedure for women with breast cancer. The goal of this study was to identify a subset of breast cancer patients in whom metastatic disease was confined only to the SLN. MATERIALS AND METHODS: From two institutions, we recruited 222 women with breast cancer for SLN biopsy. A SLN biopsy was performed in each patient, followed by an axillary dissection in 182 patients. Histologic and immunohistochemical cytokeratin stains were used on all SLNs. RESULTS: The SLN was identified in 220 (97.8%) of the 225 biopsies. Evidence of metastatic breast cancer in the SLN was found in 60 (27.0%) of the 222 patients. Of these patients, 32 (53.3%) had evidence of tumor in the SLN only. By multivariate analysis, two factors were found to be significantly associated with a higher likelihood of tumor involvement in the non-SLNs: primary tumor size larger than 2.0 cm (P = .0004) and macrometastasis (> 2.0 mm) in the SLN (P = .002). Additional analysis revealed that none (0%; 95% confidence interval, 0% to 18.5%) of the 18 patients with primary tumors ≤ 2.0 cm and micrometastasis to the SLN had remaining axillary lymph node involvement. CONCLUSION: The primary tumor size and metastasis size in the SLN are independent factors in predicting the incidence of tumor in the non-SLNs. Therefore, the SLN biopsy alone may be adequate for staging and/or therapy decision making in patients with primary breast tumors ≤ 2.0 cm and micrometastasis in the SLN.

Primary tumor size, not race, determines outcomes in women with hormone-responsive breast cancer

Surgery ◽  
2011 ◽  
Vol 150 (4) ◽  
pp. 796-801 ◽  
Author(s):  
Anees B. Chagpar ◽  
Clifford R. Crutcher ◽  
Laura B. Cornwell ◽  
Kelly M. McMasters
Keyword(s):  
Breast Cancer ◽  
Tumor Size ◽  
Primary Tumor ◽  
Primary Tumor Size
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