scholarly journals Short-term antiretroviral therapy to prevent mother-to-child transmission is safe and results in a sustained increase in CD4 T-cell counts in HIV-1-infected mothers

HIV Medicine ◽  
2009 ◽  
Vol 10 (3) ◽  
pp. 157-162 ◽  
Author(s):  
R Palacios ◽  
JF Senise ◽  
MJR Vaz ◽  
RS Diaz ◽  
A Castelo
Keyword(s):  
T Cell ◽  
Antiretroviral Therapy ◽  
Cd4 T Cell ◽  
Mother To Child Transmission ◽  
Child Transmission ◽  
Short Term ◽  
Cell Counts ◽  
Mother To Child ◽  
Hiv 1 ◽  
Sustained Increase

Low CD4 T-cell counts despite low levels of circulating HIV: Insights from the comparison of HIV-1 infected patients with a discordant response to antiretroviral therapy to patients with untreated advanced HIV-2 disease

2007 ◽  
Vol 125 (1) ◽  
pp. 67-75 ◽  
Author(s):  
Adriana S. Albuquerque ◽  
Russell B. Foxall ◽  
Catarina S. Cortesão ◽  
Rui S. Soares ◽  
Manuela Doroana ◽  
...  
Keyword(s):  
T Cell ◽  
Antiretroviral Therapy ◽  
Cd4 T Cell ◽  
Cell Counts ◽  
Low Levels ◽  
Hiv 1

Distribution of HIV-1 Plasma RNA Viral Load and CD4 + T-Cell Counts Among HIV-Infected Africans Evaluated for Antiretroviral Therapy

2001 ◽  
Vol 28 (1) ◽  
pp. 99-101 ◽  
Author(s):  
John N. Nkengasong ◽  
Marie-Yolande Borget ◽  
Chantal Maurice ◽  
Emmanuel Boateng ◽  
Mireille Kalou ◽  
...  
Keyword(s):  
Viral Load ◽  
T Cell ◽  
Antiretroviral Therapy ◽  
Cd4 T Cell ◽  
Cell Counts ◽  
Plasma Rna ◽  
Hiv 1

scholarly journals Reconstitution of Peripheral T Cells by Tissue-Derived CCR4+ Central Memory Cells Following HIV-1 Antiretroviral Therapy

2016 ◽  
Vol 1 (2) ◽  
pp. 260 ◽  
Author(s):  
Yolanda D. Mahnke ◽  
Kipper Fletez-Brant ◽  
Irini Sereti ◽  
Mario Roederer
Keyword(s):  
T Cells ◽  
Viral Load ◽  
T Cell ◽  
Antiretroviral Therapy ◽  
Cd8 T Cells ◽  
Plasma Viral Load ◽  
Cd4 T Cell ◽  
Cell Numbers ◽  
Cell Counts ◽  
Hiv 1

Background. Highly active antiretroviral therapy induces clinical benefits to HIV-1 infected individuals, which can be striking in those with progressive disease. Improved survival and decreased incidence of opportunistic infections go hand in hand with a suppression of the plasma viral load, an increase in peripheral CD4+ T-cell counts, as well as a reduction in the activation status of both CD4+ and CD8+ T cells.Methods. We investigated T-cell dynamics during ART by polychromatic flow cytometry in total as well as in HIV-1-specific CD4+ and CD8+ T cells. We also measured gene expression by single cell transcriptomics to assess functional state.Results. The cytokine pattern of HIV-specific CD8+ T cells was not altered after ART, though their magnitude decreased significantly as the plasma viral load was suppressed to undetectable levels. Importantly, while CD4+ T cell numbers increased substantially during the first year, the population did not normalize: the increases were largely due to expansion of mucosal-derived CCR4+ CD4+ TCM; transcriptomic analysis revealed that these are not classical Th2-type cells.Conclusion. The apparent long-term normalization of CD4+ T-cell numbers following ART does not comprise a normal balance of functionally distinct cells, but results in a dramatic Th2 shift of the reconstituting immune system.

scholarly journals Distribution of HIV-1 Plasma RNA Viral Load and CD4 + T-Cell Counts Among HIV-Infected Africans Evaluated for Antiretroviral Therapy

2001 ◽  
Vol 28 (1) ◽  
pp. 99-101
Author(s):  
John N. Nkengasong ◽  
Marie-Yolande Borget ◽  
Chantal Maurice ◽  
Emmanuel Boateng ◽  
Mireille Kalou ◽  
...  
Keyword(s):  
Viral Load ◽  
T Cell ◽  
Antiretroviral Therapy ◽  
Cd4 T Cell ◽  
Cell Counts ◽  
Plasma Rna ◽  
Hiv 1

scholarly journals Long-term increase in CD4+ T-cell counts during combination antiretroviral therapy for HIV-1 infection

AIDS ◽  
2010 ◽  
Vol 24 (12) ◽  
pp. 1867-1876 ◽  
Author(s):  
Judith J Lok ◽  
Ronald J Bosch ◽  
Constance A Benson ◽  
Ann C Collier ◽  
Gregory K Robbins ◽  
...  
Keyword(s):  
T Cell ◽  
Antiretroviral Therapy ◽  
Cd4 T Cell ◽  
Combination Antiretroviral Therapy ◽  
Cell Counts ◽  
Hiv 1

HIV-1–related Hodgkin lymphoma in the era of combination antiretroviral therapy: incidence and evolution of CD4+ T-cell lymphocytes

Blood ◽  
2011 ◽  
Vol 117 (23) ◽  
pp. 6100-6108 ◽  
Author(s):  
Julia Bohlius ◽  
Kurt Schmidlin ◽  
François Boué ◽  
Gerd Fätkenheuer ◽  
Margaret May ◽  
...  
Keyword(s):  
T Cell ◽  
Antiretroviral Therapy ◽  
Hodgkin Lymphoma ◽  
Cd4 T Cell ◽  
Combination Antiretroviral Therapy ◽  
Cd4 Cell Count ◽  
Cell Counts ◽  
Cd4 Cell Counts ◽  
Cd4 Cell ◽  
Hiv 1

Abstract The risk of Hodgkin lymphoma (HL) is increased in patients infected with HIV-1. We studied the incidence and outcomes of HL, and compared CD4+ T-cell trajectories in HL patients and controls matched for duration of combination antiretroviral therapy (cART). A total of 40 168 adult HIV-1–infected patients (median age, 36 years; 70% male; median CD4 cell count, 234 cells/μL) from 16 European cohorts were observed during 159 133 person-years; 78 patients developed HL. The incidence was 49.0 (95% confidence interval [CI], 39.3-61.2) per 100 000 person-years, and similar on cART and not on cART (P = .96). The risk of HL declined as the most recent (time-updated) CD4 count increased: the adjusted hazard ratio comparing more than 350 with less than 50 cells/μL was 0.27 (95% CI, 0.08-0.86). Sixty-one HL cases diagnosed on cART were matched to 1652 controls: during the year before diagnosis, cases lost 98 CD4 cells (95% CI, −159 to −36 cells), whereas controls gained 35 cells (95% CI, 24-46 cells; P < .0001). The incidence of HL is not reduced by cART, and patients whose CD4 cell counts decline despite suppression of HIV-1 replication on cART may harbor HL.

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