scholarly journals Research Review: Gene-environment interaction research in youth depression - a systematic review with recommendations for future research

2011 ◽  
Vol 52 (12) ◽  
pp. 1223-1238 ◽  
Author(s):  
Erin C. Dunn ◽  
Monica Uddin ◽  
S.V. Subramanian ◽  
Jordan W. Smoller ◽  
Sandro Galea ◽  
...  
Keyword(s):  
Systematic Review ◽  
Research Review ◽  
Future Research ◽  
Environment Interaction ◽  
Youth Depression ◽  
Gene Environment Interaction ◽  
Gene Environment ◽  
Interaction Research

Moderating Effects of Autism on Parent Views of Genetic Screening for Aggression

2012 ◽  
Vol 50 (5) ◽  
pp. 415-425
Author(s):  
Michael E. May ◽  
Rachel C. Brandt ◽  
Joseph K. Bohannan
Keyword(s):  
Genetic Screening ◽  
Children With Autism ◽  
Behavioral Symptoms ◽  
Future Research ◽  
Environment Interaction ◽  
Moderating Effects ◽  
Advocacy Groups ◽  
Gene Environment Interaction ◽  
Gene Environment ◽  
Interaction Research

Abstract Advances in gene–environment interaction research have revealed genes that are associated with aggression. However, little is known about parent perceptions of genetic screening for behavioral symptoms like aggression as opposed to diagnosing disabilities. These perceptions may influence future research endeavors involving genetic linkage studies to behavior, including proactive approaches for parents to avoid events leading to aggression. The purpose of this study was to solicit the perspectives of parents who have children with autism about screening for genes associated with aggression, compared to responses from those who have children without disabilities and those planning to have children. Parents of children with autism were more likely to support screening and the use of the results to seek treatment if necessary. Results are discussed in the context of surveillance screening and systematic early intervention for behavioral symptoms related to autism. The results may provide insight for clincians, researchers, policymakers, and advocacy groups related to diagnosing and treating aggression in people with autism.

Genetic Counselling: Its Need in Psychiatry and the Directions it Gives for Future Research

1984 ◽  
Vol 29 (4) ◽  
pp. 289-294 ◽  
Author(s):  
Harvey C. Stancer ◽  
Diane K. Wagener
Keyword(s):  
Genetic Counselling ◽  
Social Worker ◽  
Future Research ◽  
Environment Interaction ◽  
Adoption Studies ◽  
Gene Environment Interaction ◽  
Empirical Risk ◽  
Gene Environment ◽  
The Social

The methods for investigating the extent to which genetic factors can influence vulnerability to psychiatric illness are, in increasing order of precision: family, twin, and adoption studies. The evidence from these studies is in support of a gene-environment interaction for schizophrenia and the affective disorders. While the family study method cannot supply precise etiological data, the empirically derived information can be used by the genetic counsellor to provide empirical risk estimates to the counsellee. The psychiatrist, geneticist, and social worker make an appropriate team for reliable genetic counselling. The clinician must determine the precise psychiatric diagnoses in family members which the geneticist may use to estimate risk. The social worker can follow-up the counselling session or sessions to assess the counsellees’ understanding of what has been told to them. It is stressed that while genetic counselling should be available, clinical judgement should be exercised to ensure its appropriate use.

scholarly journals Intractosoma: Toward an Epistemology of Complexity Based on Intra-acting Bodies

2016 ◽  
Vol 2 ◽  
pp. 322 ◽  
Author(s):  
Sainath Suryanarayanan
Keyword(s):  
Honey Bee ◽  
Power Dynamics ◽  
Environment Interaction ◽  
Gene Environment Interaction ◽  
Politics Of Knowledge ◽  
Gene Environment ◽  
Complex Phenomena ◽  
Interaction Research ◽  
Blind Spots

In this essay, I argue for an epistemology of complexity that is centered on intra-acting—always already interacting and becoming—bodies. I utilize analyses of the politics of knowledge concerning honey bee declines and gene-environment interaction research to outline a feminist-oriented epistemology in terms of multisensorial corporealities that I call “intractosoma.” I argue that re-organizing the production of observation, reduction, and difference along the lines of an intractosomal epistemology of complexity would lead to a more accurate understanding of complex phenomena, and entail a different politics in which the constructed distance between observers and observed can no longer absolve observers of “response-ability.” By shifting the locus of concern to always already enmeshed bodies, I seek to open analyses to a plurality of observers with their associated blind-spots and power dynamics, and a multiplicity of forms of knowing and becoming, beyond instrumentation, computation and quantification..

scholarly journals A Biobehavioral Perspective on Telomere Length and the Exposome

2014 ◽  
Vol 16 (4) ◽  
pp. 448-455 ◽  
Author(s):  
Debra E. Lyon ◽  
Angela R. Starkweather ◽  
Alison Montpetit ◽  
Victoria Menzies ◽  
Nancy Jallo
Keyword(s):  
Telomere Length ◽  
Disease Risk ◽  
Future Research ◽  
Environment Interaction ◽  
Gene Environment Interaction ◽  
Disease Occurrence ◽  
Gene Environment ◽  
Genetic Mechanisms ◽  
Health And Disease ◽  
Telomere Biology

A major objective of biobehavioral research is defining the mechanisms that underlie linkages among behavior, biology, health, and disease. The genomic revolution has demonstrated the importance of studying the role of the environment in (epi)genetic mechanisms. The idea that interactions between environment and genetics influence health outcomes is a central concept of the exposome, a measure of environmental exposures throughout a lifetime. Research suggests that telomere length (TL) and biologic factors involved in telomere stability may provide an understanding of the effects of gene–environment interaction on disease risk. Telomeres, thus, have become important biomarkers for aging as well as for stress-related disease. However, incorporating telomeres into biobehavioral research requires consideration of several aspects of the exposome. Internal and external modifiable and nonmodifiable exposures have the potential to influence TL. Future research utilizing the concept of the exposome will provide meaningful findings related to exposure sources as well as dosage and duration across the life span that influence telomere biology and disease occurrence. Such findings can be translated into clinical practice and may provide a basis for personalized disease prevention and treatment approaches.

The contribution of gene–environment interaction to psychopathology

2007 ◽  
Vol 19 (4) ◽  
pp. 989-1004 ◽  
Author(s):  
Anita Thapar ◽  
Gordon Harold ◽  
Frances Rice ◽  
Kate Langley ◽  
Michael O'Donovan
Keyword(s):  
Antisocial Behavior ◽  
Molecular Genetic ◽  
Future Research ◽  
Environment Interaction ◽  
Adoption Studies ◽  
Hyperactivity Disorder ◽  
Gene Environment Interaction ◽  
Gene Environment ◽  
Molecular Genetic Evidence ◽  
Study Designs

AbstractThe study of gene–environment interaction (G × E) constitutes an area of significant social and clinical significance. Different types of research study designs are being used to investigate the contribution of G × E to psychopathology, although the term G × E has also been used and interpreted in different ways. Despite mixed evidence that G × E contributes to psychopathology, some promising and consistent findings are emerging. Evidence is reviewed in relation to depression, antisocial behavior, schizophrenia, and attention-deficit/hyperactivity disorder. Although findings from various research designs have different meaning, interestingly much of the evidence with regard to the contribution of G × E that has arisen from twin and adoption studies has been for antisocial behavior and depression. It is for these same forms of psychopathology that molecular genetic evidence of G × E has also been most convincing. Finally, current and anticipated methodological challenges and implications for future research in this area are considered.

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