Early- and late-onset startle modulation in unipolar depression

2004 ◽  
Vol 41 (3) ◽  
pp. 433-440 ◽  
Author(s):  
Gabriel S. Dichter ◽  
Andrew J. Tomarken ◽  
Richard C. Shelton ◽  
Steven K. Sutton
Keyword(s):  
Late Onset ◽  
Unipolar Depression ◽  
Startle Modulation

scholarly journals The chronometry of affective startle modulation in unipolar depression.

2008 ◽  
Vol 117 (1) ◽  
pp. 1-15 ◽  
Author(s):  
Gabriel S. Dichter ◽  
Andrew J. Tomarken
Keyword(s):  
Unipolar Depression ◽  
Startle Modulation

Morbidity Risks in Subtypes of Unipolar Depressive Illness: Differences Between Early and Late Onset Forms

1981 ◽  
Vol 139 (5) ◽  
pp. 463-466 ◽  
Author(s):  
J. Mendlewicz ◽  
M. Baron
Keyword(s):  
New York ◽  
Early Onset ◽  
Late Onset ◽  
New York State ◽  
Unipolar Depression ◽  
Depressive Illness ◽  
Psychiatric Institute ◽  
State Psychiatric ◽  
Morbidity Risks ◽  
Morbidity Risk

SummaryDespite the high prevalence of unipolar depression in the general population, few genetic studies are available on subtypes of unipolar illness. We evaluated morbid risks for depression, alcoholism and/or sociopathy in the relatives of early onset (before age 40) and late onset (after age 40) unipolar patients in a sample of 106 probands consecutively admitted to the New York State Psychiatric Institute. Unipolar patients with an early onset disease have a greater familial morbidity for depression, alcoholism and sociopathy than unipolar patients with a late onset disease. There is an excess of unipolar depression in female relatives of early onset unipolars when compared to late onset probands, regardless of the proband's sex. Alcoholism and sociopathy are also more prevalent in the relatives of early onset unipolars versus late onset probands. Our morbidity risk data show familial genetic differences between early and late onset forms of unipolar illness and partially confirm Winokur's concept of two subtypes of unipolar depression.

Mania following antidepressant discontinuation in depression: two case reports

2017 ◽  
Vol 25 (6) ◽  
pp. 617-621 ◽  
Author(s):  
Cecilia Sze Nga Kwok ◽  
Leslie Eng Choon Lim
Keyword(s):  
Selective Serotonin Reuptake Inhibitors ◽  
Tricyclic Antidepressants ◽  
Standard Treatment ◽  
Late Onset ◽  
Case Reports ◽  
Asian Population ◽  
Unipolar Depression ◽  
Chinese Patients ◽  
Manic Symptoms ◽  
History Of

Objective: Antidepressant-induced mania and an antidepressant discontinuation syndrome are well documented, whereas mania occurring after antidepressant cessation has been infrequently reported. Method: We describe antidepressant discontinuation-related mania in two Chinese patients, as well as a review of the literature on this phenomenon in unipolar depression. Results: A 72-year-old man and a 65-year-old woman had late-onset depression with vascular risk factors, but no personal or family history of mood disorders. Manic symptoms started after stopping escitalopram and venlafaxine during depressive relapse, and resolved with the initiation of olanzapine and valproate. In the literature, 29 episodes of antidepressant discontinuation-related mania were reported. Tricyclic antidepressants were most frequently implicated, followed by selective serotonin reuptake inhibitors. There was spontaneous resolution of manic symptoms in half of the cases. Conclusion: This is the first report of antidepressant discontinuation-related mania in an Asian population, in the setting of late-onset depression. This phenomenon is rare and is amenable to standard treatment.

Late-Onset Anaphylaxis to Omalizumab Reported

2006 ◽  
Vol 37 (6) ◽  
pp. 6
Author(s):  
PATRICE WENDLING
Keyword(s):  
Late Onset

Investigating the Dynamics of Suicidal Ideation

Crisis ◽  
2018 ◽  
Vol 39 (1) ◽  
pp. 65-69 ◽  
Author(s):  
Nina Hallensleben ◽  
Lena Spangenberg ◽  
Thomas Forkmann ◽  
Dajana Rath ◽  
Ulrich Hegerl ◽  
...  
Keyword(s):  
Suicidal Ideation ◽  
Small Sample Size ◽  
Unipolar Depression ◽  
Small Sample ◽  
History Of ◽  
Severity Of Depression ◽  
Ecological Momentary ◽  
Depressive Episodes ◽  
Ema Method ◽  
Shed Light

Abstract. Background: Although the fluctuating nature of suicidal ideation (SI) has been described previously, longitudinal studies investigating the dynamics of SI are scarce. Aim: To demonstrate the fluctuation of SI across 6 days and up to 60 measurement points using smartphone-based ecological momentary assessments (EMA). Method: Twenty inpatients with unipolar depression and current and/or lifetime suicidal ideation rated their momentary SI 10 times per day over a 6-day period. Mean squared successive difference (MSSD) was calculated as a measure of variability. Correlations of MSSD with severity of depression, number of previous depressive episodes, and history of suicidal behavior were examined. Results: Individual trajectories of SI are shown to illustrate fluctuation. MSSD values ranged from 0.2 to 21.7. No significant correlations of MSSD with several clinical parameters were found, but there are hints of associations between fluctuation of SI and severity of depression and suicidality. Limitations: Main limitation of this study is the small sample size leading to low power and probably missing potential effects. Further research with larger samples is necessary to shed light on the dynamics of SI. Conclusion: The results illustrate the dynamic nature and the diversity of trajectories of SI across 6 days in psychiatric inpatients with unipolar depression. Prediction of the fluctuation of SI might be of high clinical relevance. Further research using EMA and sophisticated analyses with larger samples is necessary to shed light on the dynamics of SI.

Sign in / Sign up

Export Citation Format

Share Document