RELEASE OF NOREPINEPHRINE FROM NEURONS IN DISSOCIATED CELL CULTURES OF CHICK SYMPATHETIC GANGLIA VIA STIMULATION OF NICOTINIC AND MUSCARINIC ACETYLCHOLINE RECEPTORS

1978 ◽  
Vol 30 (3) ◽  
pp. 579-586 ◽  
Author(s):  
Lloyd A. Greene ◽  
Glen Rein
Keyword(s):  
Cell Cultures ◽  
Acetylcholine Receptors ◽  
Sympathetic Ganglia ◽  
Muscarinic Acetylcholine Receptors ◽  
Muscarinic Acetylcholine ◽  
Stimulation Of

scholarly journals Differential calcium dependence in the activation of c-Jun kinase and mitogen-activated protein kinase by muscarinic acetylcholine receptors in rat 1a cells

1995 ◽  
Vol 309 (2) ◽  
pp. 381-384 ◽  
Author(s):  
F M Mitchell ◽  
M Russell ◽  
G L Johnson
Keyword(s):  
Protein Kinase ◽  
Acetylcholine Receptors ◽  
Muscarinic Acetylcholine Receptors ◽  
Mitogen Activated Protein Kinase ◽  
Muscarinic Acetylcholine ◽  
Calcium Dependent ◽  
Jun Kinase ◽  
Mapk Activity ◽  
Mitogen Activated Protein ◽  
Stimulation Of

Carbachol stimulation of the muscarinic acetylcholine m1 receptor (m1R), stably expressed in Rat 1a fibroblasts, resulted in a calcium-dependent activation of c-Jun kinase (JNK). Stimulation of the muscarinic acetylcholine m2 receptor (m2R), stably expressed in Rat 1a fibroblasts, resulted in a G1-mediated activation of JNK that was weak relative to that observed with the m1R. Chelation of calcium inhibited the m2R-mediated activation of JNK but not the robust m2R stimulation of mitogen-activated protein kinase (MAPK) activity. These findings demonstrate a role for the second messenger, calcium, in the differential regulation of the activity of JNK and MAPK in Rat 1a cells.

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