Stimulation of DOPA Synthesis in the Superior Cervical Ganglion by Veratridine

1984 ◽  
Vol 42 (2) ◽  
pp. 384-389 ◽  
Author(s):  
Joel Horwitz ◽  
Robert L. Perlman
1993 ◽  
Vol 113 (2) ◽  
pp. 146-151 ◽  
Author(s):  
Tian-Ying Ren ◽  
E. Laurikainen ◽  
W. S. Quirk ◽  
J. M. Miller ◽  
A. L. Nuttall

1975 ◽  
Vol 53 (3) ◽  
pp. 451-457 ◽  
Author(s):  
J. C. Khatter ◽  
A. J. D. Friesen

Preganglionic stimulation of the cat's superior cervical ganglion in the presence of hemicholinium-3 (HC-3) produced the expected depletion of acetylcholine (ACh) stores, but failed to cause a corresponding reduction in the choline content. These results suggest that either HC-3 possesses an intracellular site of action or that in lower doses it selectively inhibits a specialized choline transport system in cholinergic nerves. At a dose of 2 mg/kg, HC-3 probably blocked ACh synthesis completely in ganglia stimulated at 20 Hz. Under these conditions, there was a rapid depletion of ACh to about 50% of control levels during the first 5 min of stimulation and thereafter the rate of decline in ACh levels proceeded at a much slower pace. Since the 2 mg/kg dose of HC-3 did not raise plasma choline concentrations, it may be assumed that non-specialized choline transport systems in other tissues were not significantly inhibited by this dose of HC-3. However, when the dose of HC-3 was increased to 4 mg/kg, plasma choline levels increased by 58%.


1982 ◽  
Vol 242 (2) ◽  
pp. H168-H171
Author(s):  
R. S. Tuttle ◽  
M. McCleary

Sinusal distension can evoke activity in nerves supplying the superior cervical ganglion. These nerves, which have been shown to have little depressor influence, may carry an inhibitory input from the carotid sinus to the superior cervical ganglion (SCG). They have the morphological characteristics of the nerve of Hering and show cardiac pulse-related activity that may reach a maximum of 50 impulses/s during distension of the sinus. Electrical stimulation of the ascending preganglionic sympathetic trunk supplying the SCG may evoke discreet bursts of activity in these fibers, which do not summate with continued stimulation.


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