Genetic polymorphisms of drug-metabolizing enzymes CYP2D6, CYP2C9, CYP2C19 and CYP3A5 in the Greek population

2007 ◽  
Vol 21 (4) ◽  
pp. 419-426 ◽  
Author(s):  
Kostas Arvanitidis ◽  
Georgia Ragia ◽  
Maria Iordanidou ◽  
Sofia Kyriaki ◽  
Athanasia Xanthi ◽  
...  
Keyword(s):  
Genetic Polymorphisms ◽  
Greek Population ◽  
Drug Metabolizing Enzymes ◽  
Metabolizing Enzymes

Meta-analysis of contribution of genetic polymorphisms in drug-metabolizing enzymes or transporters to axitinib pharmacokinetics

2011 ◽  
Vol 68 (5) ◽  
pp. 645-655 ◽  
Author(s):  
Meghan Brennan ◽  
J. Andrew Williams ◽  
Ying Chen ◽  
Michael Tortorici ◽  
Yazdi Pithavala ◽  
...  
Keyword(s):  
Genetic Polymorphisms ◽  
Meta Analysis ◽  
Drug Metabolizing Enzymes ◽  
Metabolizing Enzymes

Importance of genetic polymorphisms of drug-metabolizing enzymes for the interpretation of biomarkers of exposure to styrene

Biomarkers ◽  
2001 ◽  
Vol 6 (3) ◽  
pp. 236-249 ◽  
Author(s):  
Vincent Haufroid ◽  
Jean-Pierre Buchet ◽  
Sophie Gardinal ◽  
Sergio Ghittori ◽  
Marcello Imbriani ◽  
...  
Keyword(s):  
Genetic Polymorphisms ◽  
Drug Metabolizing Enzymes ◽  
Metabolizing Enzymes ◽  
Biomarkers Of Exposure

scholarly journals Genetic Polymorphisms of Drug-Metabolizing Enzymes Involved in 6-Mercaptopurine-Induced Myelosuppression in Thai Pediatric Acute Lymphoblastic Leukemia Patients

2020 ◽  
Author(s):  
Kanyarat Khaeso ◽  
Nontaya Nakkam ◽  
Patcharee Komwilaisak ◽  
Piyathida Wongmast ◽  
Su-on Chainansamit ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Dna Sequencing ◽  
Allele Frequency ◽  
Genetic Polymorphisms ◽  
Pediatric Patients ◽  
Lymphoblastic Leukemia ◽  
Drug Metabolizing Enzymes ◽  
Metabolizing Enzymes ◽  
Pediatric Acute Lymphoblastic Leukemia ◽  
Pediatric All

AbstractGenetic polymorphisms of thiopurine S-methyltransferase (TPMT) and nucleoside diphosphate-linked moiety X-type motif 15 (NUDT15) genes have been proposed as key determinants of 6-mercaptopurine (6-MP)-induced myelosuppression in pediatric acute lymphoblastic leukemia (ALL). In the present study, genotypes of TPMT and NUDT15 were investigated in 178 Thai pediatric patients with ALL by the TaqMan SNP genotyping assay and DNA sequencing. The frequency of TPMT*3C was 0.034. Among NUDT15 variants, NUDT15*3 is the most common variant with the allele frequency of 0.073, whereas those of NUDT15*2, NUDT15*5, and NUDT15*6 variants were 0.022, 0.011, and 0.039. These data suggest that a high proportion of Thai pediatric ALL patients may be at risk of thiopurine-induced myelosuppression.

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