Protein kinase C beta inhibitors: a new therapeutic target for diabetic nephropathy and vascular complications

Fundamental and Clinical Pharmacology ◽

10.1111/j.1472-8206.2008.00583.x ◽

2008 ◽

Vol 22 (3) ◽

pp. 231-240 ◽

Author(s):

S Budhiraja ◽

J Singh

Keyword(s):

Diabetic Nephropathy ◽

Protein Kinase C ◽

Protein Kinase ◽

Therapeutic Target ◽

Vascular Complications ◽

Kinase C ◽

Protein Kinase C Beta

Download Full-text

A novel potential therapy for diabetic nephropathy and vascular complications: protein kinase C β inhibition

American Journal of Kidney Diseases ◽

10.1016/s0272-6386(03)00741-8 ◽

2003 ◽

Vol 42 (3) ◽

pp. 456-465 ◽

Author(s):

Katherine R Tuttle ◽

Pamela W Anderson

Keyword(s):

Diabetic Nephropathy ◽

Protein Kinase C ◽

Protein Kinase ◽

Vascular Complications ◽

Download Full-text

No support for association of protein kinase C, beta 1 (PRKCB1) gene promoter polymorphisms c.-1504C>T and c.-546C>G with diabetic nephropathy in Type 1 diabetes

Diabetic Medicine ◽

10.1111/j.1464-5491.2008.02540.x ◽

2008 ◽

Vol 25 (9) ◽

pp. 1127-1129 ◽

Author(s):

K. A. Pettigrew ◽

A. J. McKnight ◽

R. J. Martin ◽

C. C. Patterson ◽

J. Kilner ◽

...

Keyword(s):

Type 1 Diabetes ◽

Diabetic Nephropathy ◽

Protein Kinase C ◽

Protein Kinase ◽

Gene Promoter ◽

Promoter Polymorphisms ◽

Kinase C ◽

Protein Kinase C Beta

Download Full-text

Deletion of protein kinase C beta does not protect against the development of albuminuria in streptozotocin-induced experimental murine diabetic nephropathy

Diabetologie und Stoffwechsel ◽

10.1055/s-2006-943836 ◽

2006 ◽

Vol 1 (S 1) ◽

Author(s):

M Meier ◽

J Menne ◽

JK Park ◽

O Daniel ◽

C Lindschau ◽

...

Keyword(s):

Diabetic Nephropathy ◽

Protein Kinase C ◽

Protein Kinase ◽

Kinase C ◽

Protein Kinase C Beta

Download Full-text

Association of two genetic markers within the protein kinase C beta gene with type 2 diabetes mellitus

Experimental and Clinical Endocrinology & Diabetes ◽

10.1055/s-2005-862960 ◽

2005 ◽

Vol 113 (S 1) ◽

Author(s):

MA Osterhoff ◽

M Herrmann ◽

M Lazdins ◽

S Kaiser ◽

R Assert ◽

...

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Protein Kinase C ◽

Protein Kinase ◽

Genetic Markers ◽

Kinase C ◽

Beta Gene ◽

Protein Kinase C Beta

Download Full-text

Überexpression von Protein Kinase C beta im Skelettmuskel führt bei C57Bl/6 Mäusen zu Insulinresistenz

Diabetologie und Stoffwechsel ◽

10.1055/s-2006-943750 ◽

2006 ◽

Vol 1 (S 1) ◽

Author(s):

AM Hennige ◽

E Metzinger ◽

R Lammers ◽

MA Schneider ◽

R Lehmann ◽

...

Keyword(s):

Protein Kinase C ◽

Protein Kinase ◽

Kinase C ◽

Protein Kinase C Beta

Download Full-text

Untersuchung der Protein Kinase C beta II-Phosphorylierungszustände mittels zweidimensionalem Immunoblot

Aktuelle Ernährungsmedizin ◽

10.1055/s-2006-946781 ◽

2006 ◽

Vol 31 (03) ◽

Author(s):

S Richter ◽

M Osterhoff ◽

A Pfeiffer

Keyword(s):

Protein Kinase C ◽

Protein Kinase ◽

Kinase C ◽

Protein Kinase C Beta

Download Full-text

Faculty Opinions recommendation of Phase I dose escalation and pharmacokinetic study of enzastaurin, an oral protein kinase C beta inhibitor, in patients with advanced cancer.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1043078.492991 ◽

2006 ◽

Author(s):

Jeffrey Evans

Keyword(s):

Protein Kinase C ◽

Protein Kinase ◽

Phase I ◽

Advanced Cancer ◽

Pharmacokinetic Study ◽

Dose Escalation ◽

Kinase C ◽

Protein Kinase C Beta

Download Full-text

Faculty Opinions recommendation of Protein kinase C α is a central signaling node and therapeutic target for breast cancer stem cells.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.718106805.793488943 ◽

2013 ◽

Author(s):

Avri Ben-Ze'ev

Keyword(s):

Breast Cancer ◽

Protein Kinase C ◽

Protein Kinase ◽

Cancer Stem Cells ◽

Therapeutic Target ◽

Breast Cancer Stem Cells ◽

Download Full-text

Protein Kinase C – Possible Therapeutic Target to Treat Cardiovascular Diseases

Cardiovascular & Haematological Disorders - Drug Targets ◽

10.2174/187152910793743869 ◽

2010 ◽

Vol 10 (4) ◽

pp. 292-308 ◽

Author(s):

Yamini S. Bynagari-Settipalli ◽

Ramya Chari ◽

Laurie Kilpatrick ◽

Satya P. Kunapuli

Keyword(s):

Protein Kinase C ◽

Cardiovascular Diseases ◽

Protein Kinase ◽

Therapeutic Target ◽

Download Full-text

1,25-Dihydroxyvitamin D3 translocates protein kinase C beta to nucleus and enhances plasma membrane association of protein kinase C alpha in renal epithelial cells.

Journal of Biological Chemistry ◽

10.1016/s0021-9258(17)41856-4 ◽

1994 ◽

Vol 269 (5) ◽

pp. 3257-3264 ◽

Author(s):

M. Simboli-Campbell ◽

A. Gagnon ◽

D.J. Franks ◽

J. Welsh

Keyword(s):

Plasma Membrane ◽

Protein Kinase C ◽

Protein Kinase ◽

Epithelial Cells ◽

Membrane Association ◽

Dihydroxyvitamin D3 ◽

Renal Epithelial Cells ◽

1,25 Dihydroxyvitamin D3 ◽

Kinase C ◽

Protein Kinase C Beta

Download Full-text