scholarly journals The effects of indomethacin on calcium, sodium, potassium and magnesium fluxes in various tissues of the guinea-pig

1972 ◽  
Vol 45 (4) ◽  
pp. 651-659 ◽  
Author(s):  
B. J. NORTHOVER
Keyword(s):  
Guinea Pig ◽  
Sodium Potassium

Sodium, Potassium and Glutamate Content of Guinea Pig Brain Following Exposure to Oxygen at High Pressure

1957 ◽  
Vol 190 (1) ◽  
pp. 166-168 ◽  
Author(s):  
S. A. Kaplan ◽  
S. N. Stein
Keyword(s):  
High Pressure ◽  
Guinea Pig ◽  
Potassium Content ◽  
Sodium Potassium ◽  
Brain Excitability ◽  
Electrolyte Content ◽  
Pig Brain ◽  
Guinea Pig Brain

Intact animals exposed to 6.6 atm. absolute of oxygen showed a significant increase in brain sodium although the potassium content remained unchanged. There was also no change in glutamate content after exposure to OHP. The experiments seem to provide additional evidence that changes in brain electrolyte content or ‘binding’ are significant in the chain of events leading to increased brain excitability after exposure to OHP.

Sodium-Potassium Movement and the Regulation of Cardiac Muscle Activity

1982 ◽  
Vol 37 (7-8) ◽  
pp. 679-681
Author(s):  
Jürgen Daut ◽  
Reinhardt Rüdel
Keyword(s):  
Guinea Pig ◽  
Cardiac Muscle ◽  
Muscle Activity ◽  
Cardiac Glycoside ◽  
Sodium Pump ◽  
Ventricular Muscle ◽  
Sodium Potassium ◽  
Sodium Activity ◽  
Electrogenic Sodium Pump ◽  
Fast Acting

Abstract The changes in intracellular sodium activity and contractility produced by short-lasting application of a fast-acting cardiac glycoside were measured in guinea-pig ventricular muscle. It was found that under certain conditions the change in twitch tension paralleled the change in sodium activity. It is suggested that the electrogenic sodium pump may be involved in the regulation of both the mechanical and the electrical activity of cardiac muscle.

Osmotic regulation in isolated liver and kidney slices

1960 ◽  
Vol 199 (6) ◽  
pp. 1227-1231 ◽  
Author(s):  
A. G. Swan ◽  
A. T. Miller
Keyword(s):  
Guinea Pig ◽  
Osmotic Pressure ◽  
Kidney Cortex ◽  
Osmotic Regulation ◽  
Sodium Potassium ◽  
Pig Liver ◽  
Kidney Slices ◽  
Liver And Kidney ◽  
Isolated Liver ◽  
Guinea Pig Liver

Slices of guinea pig liver and kidney cortex were incubated under a variety of metabolic and osmotic conditions and the changes in tissue osmotic pressure and in water and electrolyte distribution were measured. The fresh tissues were approximately isotonic with serum, so that swelling was not due to initially hypertonic cell contents. Autolysis was not an important cause of swelling, probably because of leakage of the autolytic products from the cells. Influx of NaCl was sufficient to account for passage of water into the cells. Based on measured fluxes of sodium, potassium and chloride alone, the water of swelling was isotonic or hypertonic but never hypotonic.

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