scholarly journals Inhibition of the excitatory junction potential in the guinea-pig saphenous artery by ANAPP3

1986 ◽  
Vol 89 (1) ◽  
pp. 3-5 ◽  
Author(s):  
D.W. Cheung ◽  
M. Fujioka
Keyword(s):  
Guinea Pig ◽  
Excitatory Junction Potential ◽  
Saphenous Artery ◽  
Junction Potential

Inhibition of neuromuscular transmission in the guinea-pig saphenous artery by atriopeptrin II

1987 ◽  
Vol 65 (9) ◽  
pp. 1988-1990 ◽  
Author(s):  
M. J. MacKay ◽  
D. W. Cheung
Keyword(s):  
Guinea Pig ◽  
Sodium Nitroprusside ◽  
Inhibitory Effect ◽  
Nerve Terminals ◽  
Synaptic Potentials ◽  
Excitatory Junction Potential ◽  
Perivascular Nerves ◽  
Saphenous Artery ◽  
Junction Potential ◽  
Stimulation Of

In the guinea-pig saphenous artery, stimulation of perivascular nerves elicited contraction and two types of synaptic potentials: the excitatory junction potential and the slow depolarization. The synaptic potentials were inhibited by atriopeptin II but not by sodium nitroprusside. Exogenous noradrenaline induced membrane depolarization and contraction, and both sodium nitroprusside and atriopeptin II inhibited the contraction but not the depolarization. These results suggest that atriopeptin II has an inhibitory effect both presynaptically at the nerve terminals and postsynaptically on the vascular smooth muscle cells.

Effects of a thioreactive agent, diamide, on neuromuscular transmission in lobster

1982 ◽  
Vol 242 (1) ◽  
pp. C59-C64 ◽  
Author(s):  
C. A. Colton ◽  
J. S. Colton
Keyword(s):  
Transmitter Release ◽  
Neuromuscular Transmission ◽  
Similar Response ◽  
Free Solution ◽  
Frequency Increase ◽  
Short Term ◽  
Excitatory Junction Potential ◽  
Sites Of Action ◽  
Potential Frequency ◽  
Junction Potential

Diamide[diazine-dicarboxylic acid-bis(dimethylamide)], a thiol-oxidizing agent, has both pre- and postsynaptic actions on the glutaminergic neuromuscular junction of the lobster walking leg. Postsynaptically, diamide produced an increase in the response to exogenously applied glutamate, whereas the effect of diamide on presynaptic transmitter release involved two major changes: 1) a decrease in excitatory junction potential amplitude and 2) an increase in miniature junction potential frequency. Short-term facilitation also decreased. Equilibration with 1,4-dithiothreitol (a sulfhydryl-reducing agent) reversed the decline in excitatory junction potential frequency, and the fall in short-term facilitation. The miniature junction potential frequency increase induced by diamide was independent of external Ca2+, as diamide in a Ca2+-free solution produced a similar response to that in a Ca2+-containing solution. We propose that the action of diamide on transmitter release is similar to the action of polyvalent cations, i.e., diamide has two sites of action, a blockade of inward Ca2+ flux and an increased release of Ca2+ inside the terminal.

scholarly journals Heterologous acclimation: a novel approach to the study of thermal acclimation in the crab Cancer pagurus

1999 ◽  
Vol 277 (1) ◽  
pp. R24-R30 ◽  
Author(s):  
Timothy Pearson ◽  
David Hyde ◽  
Ken Bowler
Keyword(s):  
Central Nervous System ◽  
Tissue Temperature ◽  
Resting Potential ◽  
Acclimation Temperature ◽  
Cancer Pagurus ◽  
Novel Approach ◽  
Excitatory Junction Potential ◽  
Leg Muscle ◽  
Temperature Constant ◽  
Junction Potential

The control of the attainment of acclimation in Cancer pagurus has been studied. Homologous (8 or 22°C) and heterologous acclimation [central nervous system (CNS) and periphery of crabs simultaneously held at 8 or 22°C] were used. The dependence of electrophysiological parameters of dactylopodite closer muscles of walking legs on nerve stimulation was determined between 6 and 26°C. Muscle resting potential (RP) hyperpolarized linearly with increasing measurement temperatures and showed a 69% compensation between 8 and 22°C on homologous acclimation. With the CNS temperature constant at 8°C, the leg muscle RP showed a 72% compensation on heterologous acclimation to 8 and 22°C; when CNS temperature was constant at 22°C, leg muscle RP showed a 48% compensation on heterologous acclimation to 8 and 22°C. In homologous acclimation, the shape of the excitatory junction potential vs. temperature relationship was characteristic of acclimation temperature. In heterologous acclimation, the shape of this plot was related to the temperature experienced by the leg and not by the CNS. Thus acclimation was principally dependent on local tissue temperature and was relatively independent of CNS or hormonal influences.

Norepinephrine and ATP as Cotransmitters in the Guinea Pig Portal Vein and Rabbit Saphenous Artery

1990 ◽  
Vol 603 (1 Biological Ac) ◽  
pp. 510-512 ◽  
Author(s):  
W. L. CHAU ◽  
E. M. ANGELIS ◽  
D. P. WESTFALL
Keyword(s):  
Guinea Pig ◽  
Portal Vein ◽  
Saphenous Artery
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