Introduction: Cervical cancer in pregnancy is a rare disease, with an incidence of 0.01-0.1%, of which
most are squamous epithelial cancers. We here present the first case of a uterine cervical adenocarcinoma
during pregnancy with a concomitant papillary adenocarcinoma of the thyroid gland.
Materials and Methods: Data were extracted from the patient’s records. Literature review was performed
using the databases PubMed, Web of science and Embase.
Case Report: A 36-year-old Gravida IV, Para III was admitted to the Cantonal Hospital St. Gallen,
Switzerland with an invasive adenocarcinoma of the uterine cervix cT1B2 cNx Mx G1 ER neg PR neg Ki67
80% at 31 weeks of gestation. She was treated with 2 cycles of neoadjuvant chemotherapy (carboplatin and
paclitaxel). Following caesarean section at 36 2/7 weeks of gestation, treatment was switched to
chemoradiation therapy. The patient delivered a healthy girl. A concomitant papillary thyroid cancer pT1a,
pN1a (1/6) was successfully treated by surgery. The patient is free of recurrence and metastasis at 4.5 years
of follow-up for either of the tumors.
Conclusion: Management of cervical cancers in pregnancy has to be individualized based on factors like
gestational age, stage and histology of the cancer, and the wish for pregnancy continuation or termination.
Neoadjuvant chemotherapy seems to be a reasonable option to postpone radical surgery or chemoradiotherapy to prevent preterm delivery. To the best of our knowledge, this is the first report of a cervical
adenocarcinoma in pregnancy with a concomitant papillary thyroid cancer.
CIC-DUX4 rearranged uterine cervix round-cell sarcoma exhibiting near-complete pathologic response following radiation and neoadjuvant chemotherapy: A case report
