Linear Childhood Discoid Lupus Erythematosus Following the Lines of Blaschko: Successfully Treated with Topical Tacrolimus

Discoid lupus erythematosus (DLE) is an inflammatory autoimmune disease leading to scarring and hair loss. Linear Discoid lupus erythematosus has been mentioned in the literature as a rare variant. This article describes isolated linear DLE of the scalp. We present a 26-year-old Saudi male who had unilateral linear DLE of the scalp with no involvement of other body sites and no systemic manifestations. This case is the first case of isolated linear DLE on the scalp. This presentation should be considered as a differential diagnosis of linear scarring alopecia as a distinct morphological pattern of DLE.

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The effect of topical tacrolimus on severe recalcitrant chronic discoid lupus erythematosus

British Journal of Dermatology ◽

10.1046/j.1365-2133.2002.488616.x ◽

2002 ◽

Vol 147 (2) ◽

pp. 405-405 ◽

Cited By ~ 62

Author(s):

S.L. Walker ◽

B. Kirby ◽

R.J.G. Chalmers

Keyword(s):

Lupus Erythematosus ◽

Discoid Lupus Erythematosus ◽

Topical Tacrolimus

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Adult-onset linear discoid lupus erythematosus on the forehead mimicking en coup de sabre: a case report

Journal of Medical Case Reports ◽

10.1186/s13256-019-2249-7 ◽

2019 ◽

Vol 13 (1) ◽

Cited By ~ 1

Author(s):

Sasipaka Sindhusen ◽

Kumutnart Chanprapaph ◽

Suthinee Rutnin

Keyword(s):

Lupus Erythematosus ◽

Cutaneous Lupus Erythematosus ◽

Direct Immunofluorescence ◽

Discoid Lupus Erythematosus ◽

Adult Onset ◽

Thai Patient ◽

Case Presentation ◽

Lines Of Blaschko ◽

Children And Young Adults ◽

Cutaneous Lupus

Abstract Background Linear cutaneous lupus erythematosus (LE) is an unusual form of LE-specific cutaneous condition, occurring in children and young adults. Due to its rarity, the diagnosis of linear cutaneous LE can be difficult and facial lesions can resemble linear morphea or en coup de sabre. Differential diagnosis of similar conditions along the lines of Blaschko must be differentiated from linear LE. Case presentation We report a case of linear discoid LE on the forehead of an adult female Thai patient mimicking en coup de sabre. The dermatoscopy, histopathology and direct immunofluorescence findings were consistent with chronic cutaneous LE. Conclusions As this patient demonstrated classic dermatoscopic features of LE, we emphasized that the diagnosis of linear cutaneous LE can be made by dermatoscopy. This is particularly beneficial for young self-conscious patients with facial lesions that are reluctant to perform skin biopsy.

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Treatment of Chronic Discoid Lupus Erythematosus with Topical Tacrolimus

Acta Dermato Venereologica ◽

10.1080/00015550310007698 ◽

2004 ◽

Vol 84 (3) ◽

pp. 233-234 ◽

Cited By ~ 10

Author(s):

Daniel de la Rosa Carrillo ◽

Ole Christensen

Keyword(s):

Lupus Erythematosus ◽

Discoid Lupus Erythematosus ◽

Topical Tacrolimus

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Generalized Canine Discoid Lupus Erythematosus Responsive to Tetracycline and Niacinamide Therapy

Journal of the American Animal Hospital Association ◽

10.5326/jaaha-ms-6116 ◽

2015 ◽

Vol 51 (3) ◽

pp. 171-175 ◽

Cited By ~ 5

Author(s):

Michael A. Rossi ◽

Linda M. Messinger ◽

Keith E. Linder ◽

Thierry Olivry

Keyword(s):

Complete Remission ◽

Lupus Erythematosus ◽

Clinical Presentation ◽

Clinical Signs ◽

Skin Lesions ◽

Direct Immunofluorescence ◽

Discoid Lupus Erythematosus ◽

Topical Tacrolimus ◽

Systemic Glucocorticoids ◽

Atrophic Scars

Discoid lupus erythematosus (DLE) is a commonly reported canine autoimmune disease that normally presents with a phenotype consisting of erythema, depigmentation, scaling, erosions/ulcers, and scarring over the nasal planum and the proximal dorsal muzzle. Recently, two cases of a generalized variant of this disease have been reported, whose lesions responded to either systemic glucocorticoids or a combination of topical corticosteroids, topical tacrolimus, and the oral antimalarial hydroxychloroquine. The purpose of this report is to describe an 11 yr old shih tzu that presented with skin lesions consisting of multiple annular, erythematous papules and plaques, hyperpigmentation, adherent scaling, and atrophic scars over the caudal dorsum, flanks, craniodorsal thorax, and lateroproximal extremities. A diagnosis of generalized DLE was made based on the clinical presentation, histopathology, laboratory values, and direct immunofluorescence findings. Treatment consisted of oral tetracycline and oral niacinamide, which resulted in complete remission of clinical signs. This is the first documented report of generalized canine DLE responding to the described immunomodulating regimen. Such a combination might therefore be considered as a glucocorticoid and/or antimalarial alternative for the management of generalized DLE.

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