scholarly journals Isolated Linear Discoid Lupus Erythematosus of Scalp Following Lines of Blaschko

2019 ◽  
Vol 13 (1) ◽  
pp. 58-60
Author(s):  
Abdurrahman Almurayshid ◽  
Sulaiman Al Obaid
Keyword(s):  
Differential Diagnosis ◽  
Autoimmune Disease ◽  
Lupus Erythematosus ◽  
Discoid Lupus Erythematosus ◽  
Morphological Pattern ◽  
First Case ◽  
Lines Of Blaschko ◽  
Systemic Manifestations ◽  
Inflammatory Autoimmune Disease ◽  
Saudi Male

Discoid lupus erythematosus (DLE) is an inflammatory autoimmune disease leading to scarring and hair loss. Linear Discoid lupus erythematosus has been mentioned in the literature as a rare variant. This article describes isolated linear DLE of the scalp. We present a 26-year-old Saudi male who had unilateral linear DLE of the scalp with no involvement of other body sites and no systemic manifestations. This case is the first case of isolated linear DLE on the scalp. This presentation should be considered as a differential diagnosis of linear scarring alopecia as a distinct morphological pattern of DLE.

Systemic lupus erythematosus—clinical features and aetiopathogenesis

2013 ◽  
pp. 923-937
Author(s):  
Caroline Gordon
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Differential Diagnosis ◽  
Autoimmune Disease ◽  
Clinical Features ◽  
Lupus Erythematosus ◽  
Immune Complexes ◽  
Clinical Manifestations ◽  
Systemic Lupus ◽  
Life Threatening ◽  
Symptoms And Signs

Systemic lupus erythematosus (SLE or lupus) is a multisystem, autoimmune disease associated with the formation of autoantibodies that form pathological immune complexes and activate a number of inflammatory pathways. The disease is characterized by remissions and relapses (flares) that can present with a variety of clinical manifestations. The symptoms and signs may range from mild features that can be treated easily to organ and even life threatening manifestations requiring potent immunosuppression. This chapter will review the epidemiology and pathology of lupus, then the clinical features including differential diagnosis and investigation of adult patients with SLE. Finally the classification, diagnosis, monitoring and outcome of lupus patients will be discussed.

scholarly journals Systemic Lupus Erythematosus with Multiple Autoimmune Disease Presented with Extensive Peripheral Gangrene

2020 ◽  
Vol 2020 ◽  
pp. 1-5 ◽  
Author(s):  
Tareq Z. Alzughayyar ◽  
Jihad Samer Zalloum ◽  
Mohammad N. Elqadi ◽  
Sadi A. Abukhalaf ◽  
Fawzy M. Abunejma ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Autoimmune Disease ◽  
Lupus Erythematosus ◽  
Diabetes Mellitus Type 1 ◽  
Upper Extremities ◽  
Systemic Lupus ◽  
Skin Change ◽  
Rare Form ◽  
First Case

Systemic lupus erythematosus (SLE) is an autoimmune disease and can be associated with other autoimmune diseases. SLE usually presents with skin change and rarely presents with gangrene. SLE gangrene usually involves the digits of upper extremities. We report the first case of SLE associated with an extremely rare constellation of neuromyelitis Optica (NMO) and diabetes mellitus type 1, presented with a rare form of the SLE gangrene which involves bilateral lower extremities up to midlegs, a case that has not yet been reported in the literature. Although SLE gangrene may respond to immunosuppressants, it has a high risk of complications that can end up with amputations.

Linear Childhood Discoid Lupus Erythematosus Following the Lines of Blaschko: Successfully Treated with Topical Tacrolimus

2010 ◽  
Vol 28 (2) ◽  
pp. 205-207 ◽  
Author(s):  
YASUHIRO KAWACHI ◽  
SHIJIMA TAGUCHI ◽  
YASUHIRO FUJISAWA ◽  
JUNICHI FURUTA ◽  
YASUHIRO NAKAMURA ◽  
...  
Keyword(s):  
Lupus Erythematosus ◽  
Discoid Lupus Erythematosus ◽  
Topical Tacrolimus ◽  
Lines Of Blaschko

ROLE OF DERMATOSCOPY IN CHRONIC DERMATOSES DIAGNOSIS

2020 ◽  
pp. 53-56
Author(s):  
G. S. Chekhovska
Keyword(s):  
Differential Diagnosis ◽  
Lupus Erythematosus ◽  
Skin Diseases ◽  
Seborrheic Dermatitis ◽  
Hair Follicles ◽  
Discoid Lupus Erythematosus ◽  
Non Invasive ◽  
Invasive Method ◽  
Vascular Structures

Dermatoscopy is a valuable auxiliary non−invasive method used in the diagnosis of inflammatory, parasitic and viral skin diseases. Treatment of dermatoses is based on the results of analysis of melanin, follicular−horny and vascular components. Diagnosis begins with polarized dermatoscopy and then progresses to non−polarized using immersion fluid. At dermatoscopic inspection of a psoriatic plaque the point vessels evenly distributed along all the surface (a symptom of "scattered red pepper") are noted. Eczema is characterized by focal accumulation of blood vessels in the form of dots, peeling, yellowish crusts. Examination of discoid lupus erythematosus foci often reveals individual linear or branched vessels, their location is random. Red herpes zoster is dermatoscopically characterized by vascular structures in the form of large granular horny plugs of whitish color with a pearly sheen. The most informative is dermatoscopy in the differential diagnosis of erythematous form of rosacea and seborrheic dermatitis. On the erythematous background, dilated vessels around the sebaceous hair follicles, large vascular polygons formed from vessels thicker than in healthy skin and seborrheic dermatitis are found. At inspection of the fresh centers of a sclero−atrophic lichen diffuse unstructured zones of white color with a peripheral erythematous corolla and with numerous light comedic structures on a surface are visualized. At dermatoscopy of the Little − Lassueur syndrome in follicular papules on skin gray, violet points located in the form of a circle are noted. Dermatoscopy is increasingly used in dermatology, especially in the differential diagnosis of dermatoses of inflammatory and parasitic nature.

scholarly journals Diffuse Calcifications of the Spleen in a Woman with Systemic Lupus Erythematosus

2015 ◽  
Vol 2015 ◽  
pp. 1-3 ◽  
Author(s):  
Aristeides G. Vaiopoulos ◽  
Meletios A. Kanakis ◽  
Kyriaki Katsouri ◽  
Stavroula Kyriazi ◽  
George A. Vaiopoulos ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Differential Diagnosis ◽  
Autoimmune Disease ◽  
Connective Tissue ◽  
Lupus Erythematosus ◽  
Spontaneous Rupture ◽  
Connective Tissue Diseases ◽  
Systemic Lupus ◽  
Unique Pattern ◽  
Splenic Involvement

Systemic lupus erythematosus (SLE) is a multisystemic autoimmune disease, which affects a wide variety of organs including the spleen. Splenic involvement in SLE includes conditions such as splenomegaly, hyposplenism, infarction, and spontaneous rupture. However, only a few cases of splenic calcifications in patients with SLE have been reported. Herein, we present a case of a 24-year-old female diagnosed with SLE, in which we found diffuse splenic calcifications. The unique pattern of splenic calcifications in SLE contributes to the differential diagnosis from other conditions such as infections and other connective tissue diseases, which also cause calcifications in the spleen.

Systemic lupus erythematosus—clinical features and aetiopathogenesis

2013 ◽  
Author(s):  
Caroline Gordon
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Differential Diagnosis ◽  
Autoimmune Disease ◽  
Clinical Features ◽  
Lupus Erythematosus ◽  
Immune Complexes ◽  
Clinical Manifestations ◽  
Systemic Lupus ◽  
Life Threatening ◽  
Symptoms And Signs

Systemic lupus erythematosus (SLE or lupus) is a multisystem, autoimmune disease associated with the formation of autoantibodies that form pathological immune complexes and activate a number of inflammatory pathways. The disease is characterized by remissions and relapses (flares) that can present with a variety of clinical manifestations. The symptoms and signs may range from mild features that can be treated easily to organ and even life threatening manifestations requiring potent immunosuppression. This chapter will review the epidemiology and pathology of lupus, then the clinical features including differential diagnosis and investigation of adult patients with SLE. Finally the classification, diagnosis, monitoring and outcome of lupus patients will be discussed.

Photosensitivity and photoprotection in patients with lupus erythematosus

Lupus ◽  
2019 ◽  
Vol 28 (6) ◽  
pp. 697-702 ◽  
Author(s):  
Jusleen Ahluwalia ◽  
Amanda Marsch
Keyword(s):  
Autoimmune Disease ◽  
Lupus Erythematosus ◽  
Ultraviolet Irradiation ◽  
Systemic Disease ◽  
Clinical Manifestations ◽  
Clear Relationship ◽  
Pediatric Populations ◽  
Inflammatory Autoimmune Disease ◽  
Relationship Of

Lupus erythematosus (LE) represents a spectrum of inflammatory autoimmune disease comprising varying clinical entities ranging from primary cutaneous to systemic disease. There is a clear relationship between ultraviolet irradiation (UVR) and the clinical manifestations of LE in both adult and pediatric populations. Although it has been established that UVR exacerbates pre-existing LE, it remains unclear whether UVR induces the development of the disease. This review serves to discuss effective photoprotective measures in LE and describe the pathogenic relationship of UVR and LE.

scholarly journals Adult-onset linear discoid lupus erythematosus on the forehead mimicking en coup de sabre: a case report

2019 ◽  
Vol 13 (1) ◽  
Author(s):  
Sasipaka Sindhusen ◽  
Kumutnart Chanprapaph ◽  
Suthinee Rutnin
Keyword(s):  
Lupus Erythematosus ◽  
Cutaneous Lupus Erythematosus ◽  
Direct Immunofluorescence ◽  
Discoid Lupus Erythematosus ◽  
Adult Onset ◽  
Thai Patient ◽  
Case Presentation ◽  
Lines Of Blaschko ◽  
Children And Young Adults ◽  
Cutaneous Lupus

Abstract Background Linear cutaneous lupus erythematosus (LE) is an unusual form of LE-specific cutaneous condition, occurring in children and young adults. Due to its rarity, the diagnosis of linear cutaneous LE can be difficult and facial lesions can resemble linear morphea or en coup de sabre. Differential diagnosis of similar conditions along the lines of Blaschko must be differentiated from linear LE. Case presentation We report a case of linear discoid LE on the forehead of an adult female Thai patient mimicking en coup de sabre. The dermatoscopy, histopathology and direct immunofluorescence findings were consistent with chronic cutaneous LE. Conclusions As this patient demonstrated classic dermatoscopic features of LE, we emphasized that the diagnosis of linear cutaneous LE can be made by dermatoscopy. This is particularly beneficial for young self-conscious patients with facial lesions that are reluctant to perform skin biopsy.

Papulosquamous disease

2010 ◽  
pp. 4610-4617 ◽  
Author(s):  
Christopher Griffiths
Keyword(s):  
Differential Diagnosis ◽  
Mycosis Fungoides ◽  
Lichen Planus ◽  
Lupus Erythematosus ◽  
Secondary Syphilis ◽  
Pityriasis Versicolor ◽  
Discoid Lupus Erythematosus ◽  
Pityriasis Rosea ◽  
Drug Eruptions

Papulosquamous diseases are typically characterized by well-demarcated areas of papules and scale, typically on an erythematous background. The differential diagnosis includes psoriasis, lichen planus, mycosis fungoides, discoid lupus erythematosus, eczema/dermatitis, drug eruptions, tinea, pityriasis versicolor, secondary syphilis, and pityriasis rosea. The presence of significant pruritus is a useful marker to help with the differential diagnosis: lichen planus and discoid eczema are typically pruritic, whereas others, such as psoriasis, are less so. The distribution is also key to making the diagnosis, with psoriasis often showing characteristic symmetrical involvement of the extensor surfaces, scalp, and nails. Histology can be essential to reach a diagnosis and plan an appropriate approach to management....

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