scholarly journals Analgesic Properties of Ziconotide, a Selective Blocker of N-Type Neuronal Calcium Channels

2006 ◽  
Vol 6 (1) ◽  
pp. 1-20 ◽  
Author(s):  
Yong-Xiang Wang ◽  
S. Scott Bowersox
Keyword(s):  
Calcium Channels ◽  
Selective Blocker ◽  
Neuronal Calcium Channels

Regulation of Human Neuronal Calcium Channels by G Protein βγ Subunits Expressed in Human Embryonic Kidney 293 Cells

1997 ◽  
Vol 52 (2) ◽  
pp. 282-291 ◽  
Author(s):  
Lee R. Shekter ◽  
Ronald Taussig ◽  
Samantha E. Gillard ◽  
Richard J. Miller
Keyword(s):  
Calcium Channels ◽  
G Protein ◽  
Human Embryonic Kidney ◽  
293 Cells ◽  
Neuronal Calcium Channels

Polycyclic maleimide-based derivatives as first dual modulators of neuronal calcium channels and GSK-3β for Alzheimer's disease treatment

2019 ◽  
Vol 163 ◽  
pp. 394-402 ◽  
Author(s):  
Alessandra Bisi ◽  
Raquel L. Arribas ◽  
Matteo Micucci ◽  
Roberta Budriesi ◽  
Alessandra Feoli ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Calcium Channels ◽  
Disease Treatment ◽  
Gsk 3Β ◽  
Neuronal Calcium Channels

Chapter 6. Neuronal Calcium Channels

1995 ◽  
pp. 51-60 ◽  
Author(s):  
Jeremy Gilmore ◽  
Colin Dell ◽  
David Bowman ◽  
David Lodge
Keyword(s):  
Calcium Channels ◽  
Neuronal Calcium Channels

Ifenprodil reduces excitatory synaptic transmission by blocking presynaptic P/Q type calcium channels

2012 ◽  
Vol 107 (6) ◽  
pp. 1571-1575 ◽  
Author(s):  
Andrew J. Delaney ◽  
John M. Power ◽  
Pankaj Sah
Keyword(s):  
Calcium Channels ◽  
Synaptic Transmission ◽  
Nmda Receptors ◽  
Basolateral Amygdala ◽  
Excitatory Transmission ◽  
Voltage Dependent ◽  
Voltage Dependent Calcium Channels ◽  
P Type ◽  
Selective Blocker

Ifenprodil is a selective blocker of NMDA receptors that are heterodimers composed of GluN1/GluN2B subunits. This pharmacological profile has been extensively used to test the role of GluN2B-containing NMDA receptors in learning and memory formation. However, ifenprodil has also been reported to have actions at a number of other receptors, including high voltage-activated calcium channels. Here we show that, in the basolateral amygdala, ifenprodil dose dependently blocks excitatory transmission to principal neurons by a presynaptic mechanism. This action of ifenprodil has an IC50 of ∼10 μM and is fully occluded by the P/Q type calcium channel blocker ω-agatoxin. We conclude that ifenprodil reduces synaptic transmission in the basolateral amygdala by partially blocking P-type voltage-dependent calcium channels.

Ethanol and neuronal calcium channels

Alcohol ◽  
1990 ◽  
Vol 7 (3) ◽  
pp. 233-236 ◽  
Author(s):  
Steven W. Leslie ◽  
Laurie M. Brown ◽  
Jo Ellen Dildy ◽  
Joanne S. Sims
Keyword(s):  
Calcium Channels ◽  
Neuronal Calcium Channels
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