Allelic Variation in the GABAA Receptor gamma2 Subunit Is Associated With Genetic Susceptibility to Ethanol-Induced Motor Incoordination and Hypothermia, Conditioned Taste Aversion, and Withdrawal in BXD/Ty Recombinant Inbred Mice

BXD recombinant inbred (RI) lines represent a genetic reference population derived from a cross between C57BL/6J mice (B6) and DBA/2J mice (D2), which through meiotic recombination events possesses recombinant chromosomes containing B6 or D2 haplotype segments. The quantitative trait loci (QTLs) are the locations of segregating genetic polymorphisms and are fundamental to understanding genetic diversity in human disease susceptibility and severity. QTL mapping represents the typical approach for identifying naturally occurring polymorphisms that influence complex phenotypes. In this process, genotypic values at markers of known genomic locations are associated with phenotypic values measured in a segregating population. Indeed, BXD RI strains provide a powerful tool to study neurotoxicity induced by different substances. In this review, we describe the use of BXD RI lines to understand the underlying mechanisms of neurotoxicity in response to ethanol and cocaine, as well as metals and pesticide exposures.

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Genetic Regulation ofMycobacterium paratuberculosisInfection in Recombinant Inbred Mice

Veterinary Pathology ◽

10.1177/030098589002700509 ◽

1990 ◽

Vol 27 (5) ◽

pp. 362-364 ◽

Cited By ~ 19

Author(s):

P. F. Frelier ◽

J. W. Templeton ◽

M. Estes ◽

H. W. Whitford ◽

R. D. Kienle

Keyword(s):

Recombinant Inbred ◽

Inbred Mice ◽

Genetic Regulation ◽

Recombinant Inbred Mice

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Genetic determinants of liver fibrogenesis: a systems genetics approach in recombinant inbred mice

Liver Cirrhosis: From Pathophysiology to Disease Management ◽

10.1007/978-1-4020-8656-4_6 ◽

2008 ◽

pp. 70-74

Author(s):

R. Hall ◽

F. Lammert

Keyword(s):

Recombinant Inbred ◽

Inbred Mice ◽

Systems Genetics ◽

Genetic Determinants ◽

Recombinant Inbred Mice ◽

Liver Fibrogenesis

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Cmv-1, a genetic locus that controls murine cytomegalovirus replication in the spleen.

Journal of Experimental Medicine ◽

10.1084/jem.171.5.1469 ◽

1990 ◽

Vol 171 (5) ◽

pp. 1469-1483 ◽

Cited By ~ 215

Author(s):

A A Scalzo ◽

N A Fitzgerald ◽

A Simmons ◽

A B La Vista ◽

G R Shellam

Keyword(s):

Distribution Pattern ◽

Recombinant Inbred ◽

Strain Distribution ◽

Inbred Mice ◽

Genetic Locus ◽

Murine Cytomegalovirus ◽

Mcmv Infection ◽

Strain Distribution Pattern ◽

Recombinant Inbred Mice ◽

Hsv 1

The genetic basis of the control of acute splenic MCMV infection was studied after intraperitoneal inoculation of the virus. Classical Mendelian analyses using C57BL/6 (resistant) and BALB/c (susceptible) parental strains disclosed an autosomal dominant non-H-2 gene that regulates splenic virus replication. The probable location of this gene, to which we have assigned the symbol Cmv-1, is on chromosome 6 as defined by the strain distribution pattern of splenic MCMV replication in CXB recombinant inbred mice. Although there is a similar hierarchy of resistance to MCMV and HSV-1 with respect to the C57BL and BALB genetic backgrounds, the strain distribution pattern of HSV-1 replication in recombinant inbred mice suggests that Cmv-1 is not involved in restricting the spread of this virus. This is the first clear identification of a non-H-2 gene regulating the magnitude of MCMV infection. Elucidation of the function of this gene may be a fundamental step towards understanding the control of systemic CMV infection.

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