Genetic Regulation ofMycobacterium paratuberculosisInfection in Recombinant Inbred Mice

1990 ◽  
Vol 27 (5) ◽  
pp. 362-364 ◽  
Author(s):  
P. F. Frelier ◽  
J. W. Templeton ◽  
M. Estes ◽  
H. W. Whitford ◽  
R. D. Kienle
Keyword(s):  
Recombinant Inbred ◽  
Inbred Mice ◽  
Genetic Regulation ◽  
Recombinant Inbred Mice

scholarly journals GENETIC REGULATION OF MUP PRODUCTION IN RECOMBINANT INBRED MICE

Genetics ◽  
1979 ◽  
Vol 93 (1) ◽  
pp. 173-181
Author(s):  
P R Szoka ◽  
K Paigen
Keyword(s):  
Recombinant Inbred ◽  
Inbred Mice ◽  
Genetic Regulation ◽  
Inbred Strains ◽  
Urinary Proteins ◽  
Major Urinary Proteins ◽  
Recombinant Inbred Mice ◽  
Inbred Strains Of Mice ◽  
Before And After ◽  
Kinetics Of

ABSTRACT Inbred strains of mice excrete all three major urinary proteins (mups) when induced by testosterone, but differ as to the relative proportions and total levels of each mup present. We have now determined the urinary mup pheno-types before and after testosterone treatment of seven recombinant inbred strains derived from progenitor strains exhibiting different mup phenotypes. The results codirm previous observations indicating that total control of mup protein production is a multigenic process. One locus, Mup-a on chromosome 4, determines the relative mup protein proportions after induction by testoster- one. Mup-a, together with other genetic sites, determines the basal mup proportions. Genes other than Mup-a determine the kinetics of mup induction and total mup excretion.

scholarly journals BXD Recombinant Inbred Mice as a Model to Study Neurotoxicity

Biomolecules ◽  
2021 ◽  
Vol 11 (12) ◽  
pp. 1762
Author(s):  
Airton C. Martins ◽  
Caridad López-Granero ◽  
Beatriz Ferrer ◽  
Alexey A. Tinkov ◽  
Anatoly V. Skalny ◽  
...  
Keyword(s):  
Recombinant Inbred ◽  
Inbred Mice ◽  
Reference Population ◽  
Recombinant Inbred Mice ◽  
Complex Phenotypes ◽  
Pesticide Exposures ◽  
Underlying Mechanisms ◽  
Genomic Locations ◽  
Segregating Population ◽  
Ri Lines

BXD recombinant inbred (RI) lines represent a genetic reference population derived from a cross between C57BL/6J mice (B6) and DBA/2J mice (D2), which through meiotic recombination events possesses recombinant chromosomes containing B6 or D2 haplotype segments. The quantitative trait loci (QTLs) are the locations of segregating genetic polymorphisms and are fundamental to understanding genetic diversity in human disease susceptibility and severity. QTL mapping represents the typical approach for identifying naturally occurring polymorphisms that influence complex phenotypes. In this process, genotypic values at markers of known genomic locations are associated with phenotypic values measured in a segregating population. Indeed, BXD RI strains provide a powerful tool to study neurotoxicity induced by different substances. In this review, we describe the use of BXD RI lines to understand the underlying mechanisms of neurotoxicity in response to ethanol and cocaine, as well as metals and pesticide exposures.

scholarly journals Cmv-1, a genetic locus that controls murine cytomegalovirus replication in the spleen.

1990 ◽  
Vol 171 (5) ◽  
pp. 1469-1483 ◽  
Author(s):  
A A Scalzo ◽  
N A Fitzgerald ◽  
A Simmons ◽  
A B La Vista ◽  
G R Shellam
Keyword(s):  
Distribution Pattern ◽  
Recombinant Inbred ◽  
Strain Distribution ◽  
Inbred Mice ◽  
Genetic Locus ◽  
Murine Cytomegalovirus ◽  
Mcmv Infection ◽  
Strain Distribution Pattern ◽  
Recombinant Inbred Mice ◽  
Hsv 1

The genetic basis of the control of acute splenic MCMV infection was studied after intraperitoneal inoculation of the virus. Classical Mendelian analyses using C57BL/6 (resistant) and BALB/c (susceptible) parental strains disclosed an autosomal dominant non-H-2 gene that regulates splenic virus replication. The probable location of this gene, to which we have assigned the symbol Cmv-1, is on chromosome 6 as defined by the strain distribution pattern of splenic MCMV replication in CXB recombinant inbred mice. Although there is a similar hierarchy of resistance to MCMV and HSV-1 with respect to the C57BL and BALB genetic backgrounds, the strain distribution pattern of HSV-1 replication in recombinant inbred mice suggests that Cmv-1 is not involved in restricting the spread of this virus. This is the first clear identification of a non-H-2 gene regulating the magnitude of MCMV infection. Elucidation of the function of this gene may be a fundamental step towards understanding the control of systemic CMV infection.

scholarly journals Age-related thymic involution in C57BL/6J × DBA/2J recombinant-inbred mice maps to mouse chromosomes 9 and 10

2003 ◽  
Vol 4 (6) ◽  
pp. 402-410 ◽  
Author(s):  
H-C Hsu ◽  
H-G Zhang ◽  
L Li ◽  
N Yi ◽  
P-A Yang ◽  
...  
Keyword(s):  
Recombinant Inbred ◽  
Inbred Mice ◽  
Thymic Involution ◽  
Recombinant Inbred Mice ◽  
Age Related

scholarly journals Spontaneous Mutations in Recombinant Inbred Mice: Mutant Toll-like Receptor 4 (Tlr4) in BXD29 Mice

Genetics ◽  
2005 ◽  
Vol 172 (3) ◽  
pp. 1751-1755 ◽  
Author(s):  
Donald N. Cook ◽  
Gregory S. Whitehead ◽  
Lauranell H. Burch ◽  
Katherine G. Berman ◽  
Zareen Kapadia ◽  
...  
Keyword(s):  
Recombinant Inbred ◽  
Inbred Mice ◽  
Spontaneous Mutations ◽  
Toll Like Receptor ◽  
Toll Like Receptor 4 ◽  
Recombinant Inbred Mice

Erratum to “Genetic influences on hippocampal structure and function in recombinant inbred mice” [Behav. Brain Res. 196 (2009) 78–83]

2009 ◽  
Vol 199 (2) ◽  
pp. 364
Author(s):  
Maureen V. Martin ◽  
James D. Churchill ◽  
Hongxin Dong ◽  
David F. Wozniak ◽  
James M. Cheverud ◽  
...  
Keyword(s):  
Recombinant Inbred ◽  
Inbred Mice ◽  
Structure And Function ◽  
Genetic Influences ◽  
Recombinant Inbred Mice ◽  
And Function ◽  
Hippocampal Structure
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