Effects of Prenatal Ethanol Exposure on Basal Limbic?Hypothalamic?Pituitary?Adrenal Regulation: Role of Corticosterone

2007 ◽  
Vol 31 (9) ◽  
pp. 1598-1610 ◽  
Author(s):  
Maria M. Glavas ◽  
Linda Ellis ◽  
Wayne K. Yu ◽  
Joanne Weinberg
Keyword(s):  
Ethanol Exposure ◽  
Prenatal Ethanol Exposure ◽  
Hypothalamic Pituitary Adrenal

Ethanol neurobehavioural teratogenesis and the role of L-glutamate in the fetal hippocampus

1995 ◽  
Vol 73 (9) ◽  
pp. 1209-1223 ◽  
Author(s):  
James D. Reynolds ◽  
James F. Brien
Keyword(s):  
Fetal Alcohol Syndrome ◽  
Neuronal Development ◽  
Excitatory Amino Acid ◽  
Fetal Brain ◽  
Ethanol Exposure ◽  
Prenatal Ethanol Exposure ◽  
Fetal Alcohol ◽  
Current State ◽  
Developing Neurons

The purpose of this article is to review the current state of knowledge of ethanol neurobehavioural teratogenesis and its postulated mechanisms. The review comprises an examination of ethanol teratogenesis in the human, including the fetal alcohol syndrome, and in experimental animals. Several current proposed mechanisms of ethanol neurobehavioural teratogenesis are critically assessed, including the role of acetaldehyde as the proximate metabolite of ethanol; fetal hypoxia; placental dysfunction; fetal prostaglandin metabolism; and action of ethanol on developing neurons in the fetal brain, including the hippocampus, one of ethanol's main target sites. The effect of ethanol on the release of L-glutamate, an excitatory amino acid neurotransmitter, in the fetal hippocampus is described, and the role of L-glutamate in ethanol teratogenesis involving the hippocampus is discussed. A novel mechanism for abnormal neuronal development in the fetal hippocampus produced by prenatal ethanol exposure is presented, and future experiments to test this hypothesis are proposed.Key words: ethanol neurobehavioural teratogenesis, fetal alcohol syndrome, hippocampus, L-glutamate.

scholarly journals Effects of Prenatal Ethanol Exposure on Hypothalamic-Pituitary-Adrenal Function Across the Estrous Cycle

2009 ◽  
Vol 33 (6) ◽  
pp. 1075-1088 ◽  
Author(s):  
Ni Lan ◽  
Fiona Yamashita ◽  
Alison G. Halpert ◽  
Joanna H. Sliwowska ◽  
Victor Viau ◽  
...  
Keyword(s):  
Estrous Cycle ◽  
Ethanol Exposure ◽  
Adrenal Function ◽  
Prenatal Ethanol Exposure ◽  
Hypothalamic Pituitary Adrenal

Prenatal Ethanol Exposure Alters the Effects of Gonadectomy on Hypothalamic-Pituitary-Adrenal Activity in Male Rats

2006 ◽  
Vol 18 (9) ◽  
pp. 672-684 ◽  
Author(s):  
N. Lan ◽  
F. Yamashita ◽  
A. G. Halpert ◽  
L. Ellis ◽  
W. K. Yu ◽  
...  
Keyword(s):  
Ethanol Exposure ◽  
Male Rats ◽  
Prenatal Ethanol Exposure ◽  
Hypothalamic Pituitary Adrenal

scholarly journals Prenatal ethanol exposure induces an intrauterine programming of enhanced sensitivity of the hypothalamic–pituitary–adrenal axis in female offspring rats fed with post-weaning high-fat diet

2015 ◽  
Vol 4 (5) ◽  
pp. 1238-1249 ◽  
Author(s):  
Juan Lu ◽  
Yinxian Wen ◽  
Li Zhang ◽  
Chong Zhang ◽  
Weihua Zhong ◽  
...  
Keyword(s):  
Hpa Axis ◽  
High Fat Diet ◽  
Female Offspring ◽  
Ethanol Exposure ◽  
Prenatal Ethanol Exposure ◽  
High Fat ◽  
Hypothalamic Pituitary Adrenal ◽  
Enhanced Sensitivity ◽  
Pituitary Adrenal Axis ◽  
Intrauterine Programming

“Intrauterine programming” involved in the intrauterine origin of prenatal ethanol exposure induced enhanced sensitivity of the HPA axis in female offspring rats fed with high-fat diet.

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