Intermittent Antegrade Warm Blood Cardioplegia in Aortic Valve Replacement

1996 ◽  
Vol 11 (5) ◽  
pp. 348-354 ◽  
Author(s):  
Antonio M. Calafiore ◽  
Giovanni Teodori ◽  
Giovanni Bosco ◽  
Gabriele Di Giammarco ◽  
Giuseppe Vitolla ◽  
...  
Keyword(s):  
Aortic Valve ◽  
Aortic Valve Replacement ◽  
Valve Replacement ◽  
Blood Cardioplegia ◽  
Warm Blood ◽  
Warm Blood Cardioplegia

scholarly journals Cold crystalloid versus warm blood cardioplegia in patients undergoing aortic valve replacement

2018 ◽  
Vol 10 (3) ◽  
pp. 1490-1499 ◽  
Author(s):  
Paolo Nardi ◽  
Sara R. Vacirca ◽  
Marco Russo ◽  
Dionisio F. Colella ◽  
Carlo Bassano ◽  
...  
Keyword(s):  
Aortic Valve ◽  
Aortic Valve Replacement ◽  
Valve Replacement ◽  
Blood Cardioplegia ◽  
Warm Blood ◽  
Warm Blood Cardioplegia

The impact of del Nido cardioplegia solution on blood morphology parameters

Perfusion ◽  
2021 ◽  
pp. 026765912110490
Author(s):  
Krzysztof Sanetra ◽  
Wojciech Domaradzki ◽  
Marek Cisowski ◽  
Rajesh Shrestha ◽  
Krzysztof Białek ◽  
...  
Keyword(s):  
Aortic Valve ◽  
Aortic Valve Replacement ◽  
Blood Cell ◽  
Valve Replacement ◽  
Transfusion Rate ◽  
Blood Cardioplegia ◽  
Blood Morphology ◽  
Cold Blood ◽  
Cold Blood Cardioplegia ◽  
Morphology Parameters

Background: Crystalloid cardioplegic solutions are believed to reduce hemoglobin significantly and increase the transfusion rate. However, recent reports indicate that the del Nido cardioplegia may preserve blood morphology parameters. Methods: In “The del Nido versus cold blood cardioplegia in aortic valve Replacement” trial patients undergoing aortic valve replacement were randomized into the del Nido (DN) or cold blood cardioplegia (CB) group. For the subanalysis, patients who underwent blood transfusions were excluded from the study. Red blood cell (RBC) count, hemoglobin, white blood cell (WBC) count and platelet (PLT) count were measured before the surgery, 24-, 48-, and 96 hours postoperatively. Furthermore, percental variation in first-last measure was compared in groups. In addition, indexed normalized ratio (INR) and activated partial thromboplastin time (aPTT) were compared preoperatively and 24 hours after the surgery. Results: Eighteen (24%) patients from the del Nido group and 22 (29.3%) patients from the CB group received blood product transfusions (p = 0.560) and were excluded from further analysis. As such, 57 patients remained in DN group and 53 patients remained in CB group. No difference was found in RBC, hemoglobin, WBC, and platelet count in time intervals. Percental variation in first-last measure revealed higher fall in RBC (p = 0.0024) and hemoglobin (p = 0.0028) in the CB group. No difference was shown in preoperative and 24-hour postoperative INR and aPTT. Conclusions: The del Nido cardioplegia does not decrease blood morphology parameters when compared to cold blood cardioplegia and may be used alternatively regardless of bleeding and coagulopathy risk.

Terminal Warm Blood Cardioplegia in Mitral Valve Replacement: Prospective Study

2006 ◽  
Vol 14 (2) ◽  
pp. 134-138 ◽  
Author(s):  
Chareonkiat Rergkliang ◽  
Apirak Chetpaophan ◽  
Voravit Chittithavorn ◽  
Prasert Vasinanukorn ◽  
Vorapong Chowchuvech
Keyword(s):  
Mitral Valve ◽  
Prospective Study ◽  
Valve Replacement ◽  
Mitral Valve Replacement ◽  
Blood Cardioplegia ◽  
Warm Blood ◽  
Warm Blood Cardioplegia

Comparison of Del Nido Cardioplegia with Blood Cardioplegia in Adult Combined Surgery

2017 ◽  
Vol 12 (5) ◽  
pp. 356-362 ◽  
Author(s):  
Raphael Hamad ◽  
Anthony Nguyen ◽  
Éric Laliberté ◽  
Denis Bouchard ◽  
Yoan Lamarche ◽  
...  
Keyword(s):  
Cardiopulmonary Bypass ◽  
Aortic Valve ◽  
Aortic Valve Replacement ◽  
Valve Replacement ◽  
Myocardial Protection ◽  
Troponin T ◽  
Hospital Death ◽  
Vasoactive Agent ◽  
Blood Cardioplegia ◽  
Creatine Kinase Mb

Objective del Nido solution (DNS) is a single-dose cardioplegia designed for pediatric use proposed to offer superior myocardial protection in adults. However, few data support this claim. We hypothesized that DNS and modified blood cardioplegia solution (BS) provide equivalent safety in combined adult valve surgery. Methods Between November 2014 and December 2015, 25 patients underwent primary aortic valve replacement and concomitant coronary artery bypass grafting (CABG) with DNS. Outcomes were compared with 25 patients who underwent the same surgery with BS between September 2013 and August 2015. Results All preoperative characteristics, comorbidities, and number of CABG performed were similar between groups. One hospital death occurred in the BS group. Postoperative creatine kinase, MB isotype (16.7 ± 5.3 μg/L vs. 22.1 ± 8.9 μg/L, P = 0.011) and troponin T levels (260 ± 105.3 ng/L vs. 370.5 ±218.4 ng/L, P =0.028) were significantly lower in the DNS group. There was no difference in inotropic or vasoactive agent use ( P = 0.512). Cardiopulmonary bypass times (65.5 ± 12.5 min vs. 76.6 ± 19.1 min, P = 0.019) and cross-clamp times (55.6 ± 11.2 min vs. 64.3 ± 18.9 min, P = 0.05) were lower in the DNS group but total operating room times ( P = 0.198) were similar. Peak postoperative creatinine levels were similar in both groups ( P = 0.063). There was no difference in postoperative outcomes including acute renal failure ( P > 0.999), atrial fibrillation ( P = 0.773), acute respiratory failure ( P > 0.999), nor stroke or transient ischemic attack ( P > 0.999). Intensive care unit stay ( P = 0.213) and hospital stay ( P = 0.1) did not differ between groups. Conclusions The DNS can be used as an alternative to BS in adult concomitant aortic valve replacement + CABG surgery. This supports our hypothesis that in this specific setting, DNS provides comparable myocardial protection as BS, with possibly shorter cardiopulmonary bypass and cross-clamp times.

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