A Multivariate Two-Sample Mean Test for Small Sample Size and Missing Data

Biometrics ◽  
2006 ◽  
Vol 62 (3) ◽  
pp. 877-885 ◽  
Author(s):  
Yujun Wu ◽  
Marc G. Genton ◽  
Leonard A. Stefanski
2021 ◽  
Vol 6 ◽  
Author(s):  
Shenghai Dai ◽  
Thao Thu Vo ◽  
Olasunkanmi James Kehinde ◽  
Haixia He ◽  
Yu Xue ◽  
...  

The implementation of polytomous item response theory (IRT) models such as the graded response model (GRM) and the generalized partial credit model (GPCM) to inform instrument design and validation has been increasing across social and educational contexts where rating scales are usually used. The performance of such models has not been fully investigated and compared across conditions with common survey-specific characteristics such as short test length, small sample size, and data missingness. The purpose of the current simulation study is to inform the literature and guide the implementation of GRM and GPCM under these conditions. For item parameter estimations, results suggest a sample size of at least 300 and/or an instrument length of at least five items for both models. The performance of GPCM is stable across instrument lengths while that of GRM improves notably as the instrument length increases. For person parameters, GRM reveals more accurate estimates when the proportion of missing data is small, whereas GPCM is favored in the presence of a large amount of missingness. Further, it is not recommended to compare GRM and GPCM based on test information. Relative model fit indices (AIC, BIC, LL) might not be powerful when the sample size is less than 300 and the length is less than 5. Synthesis of the patterns of the results, as well as recommendations for the implementation of polytomous IRT models, are presented and discussed.


Author(s):  
Cristina Cañete-Massé ◽  
Maria Carbó-Carreté ◽  
María Dolores Figueroa-Jiménez ◽  
Guillermo R. Oviedo ◽  
Myriam Guerra-Balic ◽  
...  

AbstractThe presence of missing data and small sample sizes are very common in social and health sciences. Concurrently to present a methodology to solve the small sample size and missing data, we aim to present a definition of Cognitive Reserve for people with Down Syndrome. This population has become an appealing focus to study this concept because of the high incidence of dementia. The accidental sample comprised 35 persons with DS (16–35 years). A total of 12 variables were acquired, four of them had missing data. Two types of multiple imputation were made. Confirmatory factor analysis with Bayesian estimations was performed on the final database with non-informative priors. However, to solve the sample size problem, two additional corrections were made: first, we followed the Jiang and Yuan (2017) schema, and second, we made a Jackknife correlation correction. The estimations of the confirmatory factor analysis, as well as the global fit, are adequate. As an applied perspective, the acceptable fit of our model suggests the possibility of operationalizing the latent factor Cognitive Reserve in a simple way to measure it in the Down Syndrome population.


2020 ◽  
Vol 21 ◽  
Author(s):  
Roberto Gabbiadini ◽  
Eirini Zacharopoulou ◽  
Federica Furfaro ◽  
Vincenzo Craviotto ◽  
Alessandra Zilli ◽  
...  

Background: Intestinal fibrosis and subsequent strictures represent an important burden in inflammatory bowel disease (IBD). The detection and evaluation of the degree of fibrosis in stricturing Crohn’s disease (CD) is important to address the best therapeutic strategy (medical anti-inflammatory therapy, endoscopic dilation, surgery). Ultrasound elastography (USE) is a non-invasive technique that has been proposed in the field of IBD for evaluating intestinal stiffness as a biomarker of intestinal fibrosis. Objective: The aim of this review is to discuss the ability and current role of ultrasound elastography in the assessment of intestinal fibrosis. Results and Conclusion: Data on USE in IBD are provided by pilot and proof-of-concept studies with small sample size. The first type of USE investigated was strain elastography, while shear wave elastography has been introduced lately. Despite the heterogeneity of the methods of the studies, USE has been proven to be able to assess intestinal fibrosis in patients with stricturing CD. However, before introducing this technique in current practice, further studies with larger sample size and homogeneous parameters, testing reproducibility, and identification of validated cut-off values are needed.


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