The long-term effects of arteriovenous fistula creation on the development of pulmonary hypertension in hemodialysis patients

2010 ◽  
Vol 14 (4) ◽  
pp. 398-402 ◽  
Author(s):  
Aydin UNAL ◽  
Kutay TASDEMIR ◽  
Sema OYMAK ◽  
Mustafa DURAN ◽  
Ismail KOCYIGIT ◽  
...  
1993 ◽  
Vol 11 (4) ◽  
pp. 237-247 ◽  
Author(s):  
J.J.J.M. Wirtz ◽  
K.M.L. Leunissen ◽  
W. van Kuijk ◽  
E.C. Cheriex ◽  
D.W. Slaaf ◽  
...  

1998 ◽  
Vol 31 (3) ◽  
pp. 364-371 ◽  
Author(s):  
Alain Saadjian ◽  
François Philip-Joët ◽  
Franck Paganelli ◽  
Alain Arnaud ◽  
Samuel Levy

1997 ◽  
Vol 30 (2) ◽  
pp. 343-349 ◽  
Author(s):  
Shelley M Shapiro ◽  
Ronald J Oudiz ◽  
Tiesheng Cao ◽  
Matthew A Romano ◽  
X.Joy Beckmann ◽  
...  

2002 ◽  
Vol 283 (3) ◽  
pp. L555-L562 ◽  
Author(s):  
Timothy D. Le Cras ◽  
Neil E. Markham ◽  
Rubin M. Tuder ◽  
Norbert F. Voelkel ◽  
Steven H. Abman

To determine whether disruption of vascular endothelial growth factor (VEGF)-VEGF receptor (VEGFR) signaling in the newborn has long-term effects on lung structure and function, we injected 1-day-old newborn rat pups with a single dose of Su-5416, a VEGFR inhibitor, or vehicle (controls). Lungs from infant (3-wk-old) and adult (3- to 4-mo-old) rats treated with Su-5416 as newborns showed reductions in arterial density (82 and 31%, respectively) and alveolar counts (45 and 29%) compared with controls. Neonatal treatment with Su-5416 increased right ventricle weight to body wt ratios (4.2-fold and 2.0-fold) and pulmonary arterial wall thickness measurements (2.7-fold and 1.6-fold) in infant and adult rats, respectively, indicating marked pulmonary hypertension. We conclude that treatment of newborn rats with the VEGFR inhibitor Su-5416 impaired pulmonary vascular growth and postnatal alveolarization and caused pulmonary hypertension and that these effects were long term, persisting well into adulthood.


Renal Failure ◽  
2010 ◽  
Vol 32 (10) ◽  
pp. 1148-1152 ◽  
Author(s):  
Ahmet Alper Kiykim ◽  
Mehmet Horoz ◽  
Turkay Ozcan ◽  
Ibrahim Yildiz ◽  
Sibel Sari ◽  
...  

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