Long-Term Effects of Cicletanine on Secondary Pulmonary Hypertension

1998 ◽  
Vol 31 (3) ◽  
pp. 364-371 ◽  
Author(s):  
Alain Saadjian ◽  
François Philip-Joët ◽  
Franck Paganelli ◽  
Alain Arnaud ◽  
Samuel Levy
Keyword(s):  
Pulmonary Hypertension ◽  
Long Term Effects ◽  
Secondary Pulmonary Hypertension

scholarly journals Long term effects of cicletanine on secondary pulmonary hypertension

1996 ◽  
Vol 27 (2) ◽  
pp. 218
Author(s):  
Alain Saadjian ◽  
François Philip-Joët ◽  
Franck Paganelli ◽  
Alain Amaud ◽  
Samuel Levy
Keyword(s):  
Pulmonary Hypertension ◽  
Long Term Effects ◽  
Secondary Pulmonary Hypertension

scholarly journals Primary Pulmonary Hypertension: Improved Long-Term Effects and Survival With Continuous Intravenous Epoprostenol Infusion

1997 ◽  
Vol 30 (2) ◽  
pp. 343-349 ◽  
Author(s):  
Shelley M Shapiro ◽  
Ronald J Oudiz ◽  
Tiesheng Cao ◽  
Matthew A Romano ◽  
X.Joy Beckmann ◽  
...  
Keyword(s):  
Pulmonary Hypertension ◽  
Primary Pulmonary Hypertension ◽  
Long Term Effects

The long-term effects of arteriovenous fistula creation on the development of pulmonary hypertension in hemodialysis patients

2010 ◽  
Vol 14 (4) ◽  
pp. 398-402 ◽  
Author(s):  
Aydin UNAL ◽  
Kutay TASDEMIR ◽  
Sema OYMAK ◽  
Mustafa DURAN ◽  
Ismail KOCYIGIT ◽  
...  
Keyword(s):  
Pulmonary Hypertension ◽  
Arteriovenous Fistula ◽  
Hemodialysis Patients ◽  
Long Term Effects

Treatment of newborn rats with a VEGF receptor inhibitor causes pulmonary hypertension and abnormal lung structure

2002 ◽  
Vol 283 (3) ◽  
pp. L555-L562 ◽  
Author(s):  
Timothy D. Le Cras ◽  
Neil E. Markham ◽  
Rubin M. Tuder ◽  
Norbert F. Voelkel ◽  
Steven H. Abman
Keyword(s):  
Pulmonary Hypertension ◽  
Vegf Receptor ◽  
Newborn Rats ◽  
Long Term Effects ◽  
Adult Rats ◽  
Rat Pups ◽  
Lung Structure ◽  
Vegfr Inhibitor ◽  
And Function

To determine whether disruption of vascular endothelial growth factor (VEGF)-VEGF receptor (VEGFR) signaling in the newborn has long-term effects on lung structure and function, we injected 1-day-old newborn rat pups with a single dose of Su-5416, a VEGFR inhibitor, or vehicle (controls). Lungs from infant (3-wk-old) and adult (3- to 4-mo-old) rats treated with Su-5416 as newborns showed reductions in arterial density (82 and 31%, respectively) and alveolar counts (45 and 29%) compared with controls. Neonatal treatment with Su-5416 increased right ventricle weight to body wt ratios (4.2-fold and 2.0-fold) and pulmonary arterial wall thickness measurements (2.7-fold and 1.6-fold) in infant and adult rats, respectively, indicating marked pulmonary hypertension. We conclude that treatment of newborn rats with the VEGFR inhibitor Su-5416 impaired pulmonary vascular growth and postnatal alveolarization and caused pulmonary hypertension and that these effects were long term, persisting well into adulthood.

Human Immunodeficiency Viruses and its effect on the Pulmonary Vascular bed

2021 ◽  
Author(s):  
Ghazwan Butrous
Keyword(s):  
Pulmonary Hypertension ◽  
Illicit Drugs ◽  
Clinical Effects ◽  
Long Term Effects ◽  
Vascular Bed ◽  
Human Immunodeficiency Viruses ◽  
Vascular Beds ◽  
The Impact ◽  
Pulmonary Vascular Bed

December. 1st 2021 is "World AIDS Day" reminding us that HIV infection is still widespread and that many of its long-term effects can be deadly. One of these complications is its effect on the pulmonary vascular beds, leading to an increase in the pulmonary pressure, causing the clinical manifestation of "pulmonary hypertension". Unfortunately, we are still far from fully understanding the prevalence, mechanics, and pathobiology of "HIV pulmonary hypertension", especially in Africa and other developing countries where HIV is still common. In addition, the impact of other factors like co-infection and illicit drugs can add and modify the effect on the pulmonary vascular bed, complicating the pathological and clinical effects of HIV. Thus, "World AIDS Day" can be an impetus to pursue further research in this area.

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