Stimulation of the nitric oxide-guanosine 3', 5'-cyclic monophosphate pathway by sildenafil: Effect on rectal muscle tone, distensibility, and perception in health and in irritable bowel syndrome

2003 ◽  
Vol 98 (10) ◽  
pp. 2253-2260 ◽  
Author(s):  
Eva Fritz ◽  
Johann Hammer ◽  
Barbara Schmidt ◽  
Andreas J. Eherer ◽  
Heinz F. Hammer
Keyword(s):  
Nitric Oxide ◽  
Irritable Bowel Syndrome ◽  
Muscle Tone ◽  
Cyclic Monophosphate ◽  
Irritable Bowel ◽  
Rectal Muscle ◽  
Stimulation Of

scholarly journals The Colonic Tissue Levels of TLR2, TLR4 and Nitric Oxide in Patients with Irritable Bowel Syndrome

2016 ◽  
Vol 55 (9) ◽  
pp. 1043-1048 ◽  
Author(s):  
Erdem Koçak ◽  
Erdem Akbal ◽  
Seyfettin Köklü ◽  
Bilal Ergül ◽  
Murat Can
Keyword(s):  
Nitric Oxide ◽  
Irritable Bowel Syndrome ◽  
Colonic Tissue ◽  
Tissue Levels ◽  
Irritable Bowel

Rectal Mucosal Nitric Oxide in Differentiation of Inflammatory Bowel Disease and Irritable Bowel Syndrome

2005 ◽  
Vol 3 (8) ◽  
pp. 777-783 ◽  
Author(s):  
Claudia I. Reinders ◽  
Max Herulf ◽  
Tryggve Ljung ◽  
Jakob Hollenberg ◽  
Eddie Weitzberg ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Inflammatory Bowel Disease ◽  
Irritable Bowel Syndrome ◽  
Bowel Disease ◽  
Inflammatory Bowel ◽  
Irritable Bowel

Possible role of nitric oxide in visceral hypersensitivity in patients with irritable bowel syndrome

2006 ◽  
Vol 18 (2) ◽  
pp. 115-122 ◽  
Author(s):  
s. d. kuiken ◽  
t. k. klooker ◽  
g. n. tytgat ◽  
a. lei ◽  
g. e. boeckxstaens
Keyword(s):  
Nitric Oxide ◽  
Irritable Bowel Syndrome ◽  
Visceral Hypersensitivity ◽  
Irritable Bowel

scholarly journals Irritable bowel syndrome with constipation: issues of pathogenesis, diagnostics and treatment

2020 ◽  
Keyword(s):  
Nitric Oxide ◽  
Irritable Bowel Syndrome ◽  
Endothelial Dysfunction ◽  
Vascular Endothelium ◽  
Bowel Movement ◽  
Food Allergies ◽  
Endocrine Disorders ◽  
Endothelin 1 ◽  
Complex Therapy ◽  
Irritable Bowel

Issues related to the diagnosis and treatment of irritable bowel syndrome occupy one of the central places in gastroenterology, due to the fact that in recent years there has been a significant increase in the incidence of this syndrome, its long-term recurrent, often lifelong course, leading to a decrease in the performance of patients, despite good quality, and a significant cost to the health care system. Irritable bowel syndrome, despite its functional nature, occurs quite often - from 14-50% of the adult population according to population epidemiological studies, and the ratio of women to men is from 2: 1 to 4:1. In the structure of gastroenterological pathology, this disease accounts for 40-70% of all cases of seeking medical help. Irritable bowel syndrome is a complex of functional disorders of the distal intestines, lasting more than 3 months and accompanied by abdominal pain that disappears after a bowel movement, flatulence, a feeling of incomplete bowel movement, changes in the frequency and consistency of stools. Factors in the pathogenesis of irritable bowel syndrome are dysfunction of mental activity with changes in autonomic and humoral functions; visceral hypersensitivity and impaired intestinal motility, past intestinal infection; endocrine disorders; food allergies, sedentary lifestyle; genetic predisposition. Endothelial dysfunction has recently played an important role in the onset of irritable bowel syndrome. The most famous among the factors of vascular endothelium today are the powerful vasoconstrictor endothelin-1 and the vasodilator - nitric oxide. The study investigated the level of vasoconstrictor endothelin-1 and vasodilator of nitric oxide in patients with irritable bowel syndrome with constipation. It was found that such patients have severe endothelial dysfunction, which manifests itself in an increase in the level of endothelin-1 (р˂0,01), a decrease in the level of nitric oxide (р˂0,01). The data obtained indicate the role of dysfunction of the vascular endothelium in the pathogenesis of irritable bowel syndrome with constipation. An inverse correlation was found between the content of endothelin-1 and nitric oxide (p˂0.01), which indicates an increase in the activity of vasoconstrictor mechanisms with a simultaneous decrease in vasodilation factors. The effectiveness of complex therapy in the group of patients in whom folic acid and zincteral were used as part of complex therapy in improving the clinical picture of the disease (complete relief of dyspeptic syndrome and a significant decrease in the severity of pain, constipation and asthenic syndromes), restoration of vascular endothelial function (significant decrease in the level of endothelin-1 and an increase in the level of nitric oxide) in comparison with the group of patients in the treatment of which only basic therapy was used.

scholarly journals Dimensions of Gut Dysfunction in Irritable Bowel Syndrome: Altered Sensory Function

1999 ◽  
Vol 13 (suppl a) ◽  
pp. 12A-14A ◽  
Author(s):  
Fernando Azpiroz
Keyword(s):  
Irritable Bowel Syndrome ◽  
Clinical Symptoms ◽  
Afferent Input ◽  
Sensory Function ◽  
Visceral Hyperalgesia ◽  
Gut Dysfunction ◽  
Irritable Bowel ◽  
Clinical Conditions ◽  
Normal Perception ◽  
Stimulation Of

Growing evidence suggests that symptoms in patients with irritable bowel syndrome (IBS) may be due to a visceral sensory dysfunction. Specifically, it has been shown that patients with IBS have hypersensitive responses to distension of the rectum, whereas their tolerance to somatic stimuli is normal or even increased. Furthermore, patients with IBS have hypersensitivity of the small bowel, which selectively affects mechanosensitive afferents, with normal perception of electrical stimulation of the gut. Sensory dysfunctions may also be associated with altered reflex activity, which may contribute to the clinical symptoms. Normally, a series of mechanisms at different strata of the nervous system modulate visceral afferent input and determine conscious perception. Conceivably, a dysfunction of these regulatory mechanisms may alter sensitivity in clinical conditions. To date, neither the origin nor the clinical significance of visceral hyperalgesia has been elucidated. However, it seems likely that the sensory and reflex dysfunctions of the gut in IBS may combine to different degrees, and their interaction may explain the clinical pleomorphism of the syndrome.

Antinociceptive and antidiarrheal effects of pioglitazone in a rat model of diarrhoea-predominant irritable bowel syndrome: Role of nitric oxide

2014 ◽  
Vol 41 (2) ◽  
pp. 118-126 ◽  
Author(s):  
Pedram Paragomi ◽  
Reza Rahimian ◽  
Mohammad Hossein Kazemi ◽  
Mohammad Hadi Gharedaghi ◽  
Amin Khalifeh-Soltani ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Irritable Bowel Syndrome ◽  
Rat Model ◽  
Irritable Bowel
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