Treatment of idiopathic hemifacial spasm with botulinum toxin

2009 ◽  
Vol 85 (1) ◽  
pp. 55-57 ◽  
Author(s):  
Y. L. Yu ◽  
K. Y. Fong ◽  
C. M. Chang
Author(s):  
Selly Marisdina ◽  
Henry Sugiharto ◽  
A Pradian

Back Ground: Hemifacial spasm is one of movement disorder case that commonly found in daily clinical practice. Epidemiological data are very limited, the average prevalence is 11 per 100,000 population, 14.5 per 100,000 in women and 7.4 per 100,000 in men. In Germany, the estimated prevalence is 8000 to 9000 peoples.1 The incidence of women is more than that of men with a ratio of 2:1. Based on Yaltho and Jankovic study in 2011, out of 215 patients, the ratio of men to women was 1:1.8.2 One study in Indonesia also reported that most of the subjects were female (64.7%).3 Treatment with botulinum toxin injections is preferred to microvascular decompression surgery therapy, but this injection is only effective in a few months and quite expensive. This study is the first study to assess the effectiveness of dry needling on clinical improvement of hemifacial spasm compared to standard therapy of botulinum toxin injection.Methods: The study design was quasi experimental. Total of 24 subjects were divided into two groups. The first group underwent dry needling intervention while the other had botulinum injection. Clinical severity before and after treatment in both groups was assessed using Jankovic and HFS7 scores.Results: In dry needling group there were significant differences between Jankovic and HFS7 score at baseline and at week 1, 2, 3 and 4. While in botox group significant differences were also Jankovic and HFS7 score at baseline and at weeks 2 and 4. There were also a significant difference of Jankovic and HFS7 score when we compared dry needling group to botulinum toxin group.Conclusion: Dry needling can be an alternative treatment for hemifacial spasm, although clinical improvements based on Jankovic and HFS7 scores in dry needling group were not as effective as those with botulinum toxin injections.


Toxicon ◽  
2008 ◽  
Vol 51 ◽  
pp. 30-31
Author(s):  
Kollewe Katja ◽  
Krampfl Klaus ◽  
Bigalke Hans ◽  
Dengler Reinahrd ◽  
Mohammadi Bahram

2012 ◽  
Vol 34 (2) ◽  
pp. 209-215 ◽  
Author(s):  
C. Butera ◽  
R. Guerriero ◽  
S. Amadio ◽  
D. Ungaro ◽  
H. Tesfaghebriel ◽  
...  

2021 ◽  
Vol 2 (2) ◽  
pp. 83-87
Author(s):  
Kenneth K.H. Lai ◽  
◽  
Edwin Chan ◽  
Simon T.C. Ko ◽  
◽  
...  

AIM: To report the therapeutic outcomes of botulinum toxin A (Botox) and eyelid surgery in patients with hemifacial spasm (HFS). METHODS: Patients’ images and medical notes were retrospectively reviewed with subsequent analysis of both the therapeutic outcomes and complications of Botox injections. RESULTS: The information of 76 patients (female=58) with HFS who received a minimum of 4 Botox injections were included. The mean follow-up interval was 83±50 (20-112)mo with an average of 16±10 (4-34) injections. The peak incidence was between 55 and 64 years and the average age of onset was 66±11 (32-85)y. Up to 23% of patients with HFS had aberrant vascular structures (right=8, left=7) in close relationship to the facial nerve (MRI=14, CT=1), where the vertebral artery (n=6) was the most involved vessel followed by the anterior inferior cerebellum artery (n=5). Patients with primary HFS had a shorter effective duration (2.5 vs 3.1mo, P<0.05), a longer onset time (4.1 vs 3.8d, P=0.739) and a lower Subjective Spasm Alleviation score (SSAs; 1.7 vs 1.9, P=0.179) than those with secondary HFS. Twelve of the 19 patients with preexisting eyelid diseases underwent surgical correction including upper blepharoplasty (n=12), limited myectomy (n=7), browplasty (n=7) and advancement of levator aponeurosis (n=5). Five (41.7%) of those with surgical correction and suboptimal response to Botox showed improvement 6mo after surgery [onset time (P=0.0256), effective duration (P=0.374) and SSAs (P=0.0161)]. Those 12 patients with eyelid surgery had a lower complication rate than those without eyelid surgery (23% vs 42%, P≤0.05). CONCLUSION: Botox is an effective and safe treatment for HFS. Patients with primary HFS had a less favorable therapeutic outcome with Botox than those with secondary HFS. Eyelid surgery for patients with concurrent eyelid diseases can augment the effect of subsequent Botox injections by improving patient satisfaction and reducing complication rate.


Author(s):  
Gonçalo S Duarte ◽  
Filipe B Rodrigues ◽  
Mafalda Castelão ◽  
Raquel E Marques ◽  
Joaquim Ferreira ◽  
...  

2006 ◽  
Vol 9 (2-3) ◽  
pp. 141-144 ◽  
Author(s):  
C. Lorenzano ◽  
S. Bagnato ◽  
F. Gilio ◽  
G. Fabbrini ◽  
A. Berardelli

2018 ◽  
Vol Volume 15 ◽  
pp. 33-36 ◽  
Author(s):  
Hongjuan Dong ◽  
Shanghua Fan ◽  
Ying Luo ◽  
Bin Peng

Toxicon ◽  
2018 ◽  
Vol 156 ◽  
pp. S42
Author(s):  
Bruno Guimarães ◽  
Vítor Brás Silva ◽  
Catarina Aguiar-Branco ◽  
Alexandre Camões-Barbosa

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