Antiviral Therapy in Corona Virus Disease-19 (Covid-19)

Coronavirus disease 2019 (COVID-19) is a disease caused by a new coronavirus called severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, previously known as 2019-nCoV), which was first identified in Wuhan City, Hubei Province, PRC. The total number of COVID-19 cases worldwide has reached 102 million cases with 54 million cases recovered and 2.3 million cases dead. Handling for this pandemic is still being carried out. In Indonesia, the antiviral drugs used are those that meet the Emergency Use Authorization (EUA) requirements, and are included in the COVID-19 management guidelines issued by the Ministry of Health. Antiviral options used are Oseltamivir, Favifirapir, Remdesivir. Until now, the use of antivirus is still being researched regarding the effectiveness and security of the antivirus used. Oseltamivir is used as an antiviral for COVID-19 with a mild clinical course, Favifirapir is used for mild to moderate clinical cases of COVID-19. For the use of remdesivir in COVID-19 patients with severe and critis clinical conditions.

The Hepatoprotective Effects of Basil Leaf (Ocimum sanctum L.) Extract on Paracetamol Induced Liver Damage in Male Rat

Basil leaf have antioxidants such as flavonoids, so it is thought to have a hepatoprotective effect. This study aims to investigate the effect of basil leaf extract on SGOT and SGPT levels in male rats induced by paracetamol. Basil leaf extract was carried out by the percolation method using ethyl acetate solvent, Some 20 male sprague dawley rats were randomly divided into 5 groups. Basil leaf extract (400 mg/kgBB and 600 mg/kgBB) and sylimarin (100 mg/kgBB) were carried out every day for 28 days, paracetamol was induced 24 hours after giving the last day of basil leaf extract. The parameters measured were SGOT and SGPT level to assess the effect of basil leaf extract on liver damage caused by paracetamol. The results showed that basil leaf extract (400 mg/kgBB dan 600 mg/kgBB) showed that the activities of SGOT and SGPT levels were statistically significant (p<0,05) to negative control. Basil leaf extract shows the effect of hepatoprotector on liver induced by paracetamol, however the effect given was not able to equate with positive control.

Severe Anemia in Non Suicide Self Injury as a Complication of Major Depression Disorder

Non suicide self injury (NSSI) is a rare case in adults. Non suicide self injury is an act of hurting himself such as cutting, burning, punching without intending to commit suicide. NSSI itself is a complication of major depression that is not treated properly from the onset of symptoms. Severe depression that lasts for a long time, can aggravate illnesses such as the appearance of symptoms of psychosis and have an impact on various complications such as NSSI and somatic complications that can reduce the patient's health condition. Reported a case of a 22 year old woman with severe anemia due to chronic bleeding. It is known that chronic bleeding in the patient is the result of habitual cutting, in which the patient slashes her left forearm. Cutting habitualis is part of the action of NSSI where the management must be holistic and sustainable, the management of patients consists of psychotherapy as starting from dialectical behavior therapy is a form of cognitive therapy that can help a person adapt to activities that can pass through distress. Psychodynamic therapy is to help someone form new habits that previously could cause pleasure to the patient. Psychotherapy accompanied by psychopharmaceuticals can accelerate improvement in patient.

Hepatitis Lupus in Systemic Lupus Erythematosus in Male Patients

Systemic Lupus Erythematosus (SLE) is a complex autoimmune disease characterized by autoantibodies against the cell nucleus and involves many organ systems in the body with unknown etiologies and various clinical manifestations, disease course and prognosis. SLE can be found at all ages, generally appearing at age 9-58 years with a peak at age 28 years. It is more common in women with a ratio of women to men 15: 1 to 22: 1. The highest incidence and prevalence of SLE was found in North America 23.2 / 100.000 population / year and 241 / 100.0000 population. In Indonesia, there has been an increase in visits to SLE patients from 17.9-27.2% in 2015 to 30.3-58% in 2017. One of the manifestations of SLE is hepatitis lupus, which is inflammation of the liver tissue. Lupus hepatitis can occur in 20-50% of patients with SLE. It was reported that a 20-year-old man presented with complaints of pain in the joints of the right and left hands which increased since 1 week. The patient also complained of reddish patches on the face, hair loss and mouth sores. Physical examination revealed anemic eye conjunctiva, malar rash, oral ulcer. During the joint examination, there was tenderness in bilateral MCP and PIP. The abdominal examination revealed hepatomegaly. Investigations revealed anemia, thrombocytopenia, increased liver function. Abdominal ultrasound revealed hepatomegaly. ANA profile examination was positive for anti RNP, anti-sm, and anti- ribosomal protein antibodies. The patient was diagnosed with Systemic Lupus Erythematosus with lupus hepatitis according to the ACR (American College of Rheumatology) criteria in which the patient had 6 criteria. The patient was given therapy with 2x125 mg of intravenous methyl prednisolone for 3 days and hydroxychloroquine 1x200 mg orally and other symptomatic drugs.

Effectivity of Jatropha multifida L. Leaves Extract as Antibacterial on Streptococcus mutans using In Vitro Testing Methods

Intoduction: Health is the condition of the entire body and body parts of an individual who is free from disease both physically, mentally and socially, thus enabling the individual to be able to carry out daily activities more productively. However, many people neglect their own health, especially in the field of dental and oral health. Caries is one of the most common oral and dental problems. The prevalence of dental caries in Indonesia is high, namely 88.8%. Dental caries is caused by Streptococcus mutans bacteria which plays a role in the conversion of sucrose to lactic acid. Infection due to Streptococcus mutans bacteria can be treated by taking antibiotics. Apart from drugs, antibiotics can also be obtained from natural ingredients, one of which is the tintir castor plant (Jatropha multifida Linn) or commonly known as the betadine. Objective: To see the effect of the antibacterial content of tintir leaves against Streptococcus mutans bacteria and to determine the differences in the antibacterial effect of betadine leaf extract (Jatropha multifida L.) from a concentration of 25%, 50%, 75%, and 100% against Streptococcus mutans. Methods: The type of research used in this study was a laboratory experimental study with a post-test-only control group design as the research design and to test the sensitivity of bacteria using the paper disc diffusion test. Data analysis using One-Way ANOVA. Result: The results of this study indicate the effect of tintir castor leaf extract (Jatropha multifida L.) in inhibiting the growth of Streptococcus mutans bacteria.

The Effect of Pure Garlic (Allium Sativum L.) Juice on The Color Stability of Heat Polymerized Acrylic Resin Denture Base

Intoduction : PMMA or acrylic resin is a necessary material in dentistry for denture bases, one of which is often used is heat cured acrylic resin or heat polymerized acrylic resin. Garlic juice is a denture cleaner to inhibit bacteria and is also an extrinsic factor that causes discoloration. Purpose: To determine the duration of immersion in pure garlic juice which can cause discoloration of the acrylic resin. Methods: laboratory experiments with posttest only control group design research. Results: The mean ± SD change in color of hot polymerized acrylic resin after immersing in garlic juice for 2, 4, 6, 8 hours was 0.67 ± 0.22; 0.91 ± 0.31; 1.22 ± 0.32; and 1.56 ± 0.25. Conclusion: There is an effect of soaking time with garlic juice on the base of denture acrylic resin on discoloration.

Correlations Between Mandibular Third Molars to Inferior Alveolar Nerve Locations in Vietnamese Population

One of the probable complications in mandibular third molar extraction is thedamage to the inferior alveolar nerve (IAN). Calculating the distance between IANand third mandibular can decrease the complication risk. In this study, cone beamcomputed tomography (CBCT) scans were used to evaluate several factors relatedto the positional relationship between mandibular third molar and IAN in theVietnamese population. One-hundred-seventy-eight CBCT scans were collectedfrom dental clinics at Ho Chi Minh City, from 1st January 2018 to 28th February2021. Only 100 scans were included in this study, 55 scans of female and 45 scansof male patients. The age of the patients ranged from 19 to 59 years old. From thisstudy, the most common location of IAN relative to the roots of the mandibularthird molar was on the apical side (60.5%), followed by the buccal side (21.5%), thelingual side (16%), and the least common located between the roots (2%). Overall,the mean distance between mandibular third molar roots to IAN was 3.19±1.85mm. There was a significant correlation between the left and right sides ofthe IAN location, indicating symmetry. Moreover, there is no association was foundbetween gender and the location of IAN

Activity of Averrhoa Bilimbi L Leaf Extract as Denture Cleaner Towards The Number of Colonies of Candida Albicans in Heat Cured Resin with a 30 Minutes Period

Denture stomatitis is a chronic inflammatory condition of the oral mucosa thatgenerally occurs in users of removable dentures. The cause is multifactorialbut is often associated with the presence of Candida albicans. The mucosawhich is covered by the denture base also reduces the function of saliva whichfunctions as a cleanser for the oral cavity and results in food wasteaccumulating and microorganisms such as Candida albicans can increase innumber. Candida albicans is a normal flora of the oral cavity which is anopportunistic pathogen. The starfruit plant (Averrhoa billimbi l) is a naturalingredient that can be used as an antifungal agent. The aim was to determinethe ratio of the effectiveness of starfruit leaf extract (Averrhoa billimbi) betweenthe concentrations of 12.5%, 25%, 50%, 100%, control + (Clorhexidine) andcontrol - (Aquadest) in reducing the number of Candida albicans colonies. Thetest method used the dilution method, the colony count of Candida albicansusing a spectrophotometer. The results of the one way ANOVA statistical testresulted in a significance value of p = 0.000 (p <0.05) which means that thereis a difference in the average concentration of Candida albicans between theextract concentrations of 12.5%, 25%, 50%, 100%, control + and control. -namely 6.78 ± 0.35, 6.27 ± 0.21, 4.89 ± 0.29, 1.01 ± 0.18, 0.59 ± 0.19 and 9.13± 2.28 in inhibiting growth Candida albicans and this was confirmed by theTukey HSD posthoc test. The conclusion of this study is that there is adifference between the antifungal effectiveness of starfruit leaf extract(Averrhoa billimbi) concentrations of 12.5%, 25%, 50% and 100% in inhibitingthe growth of Candida albicans colonies.

Effectiveness of Tamarillo Skin Extract (Solanum betaceum Cav.) with Sealer Combination in Inhibiting Growth of Enterococcus faecalis

Introduction : Caries is a growth medium for pathogenic micro-organisms an inflammatory process can occur which can cause damage to the tooth pulp. Enterococcus faecalis one of the Gram-positive facultative anaerobes which causes failure after endodontic treatment. In the field of dentistry, herbal ingredients can be used as alternative medicinal ingredients because the ingredients is tamarillo skin which contains flavonoids, terpenoids, saponins and phenol compounds. In addition to herbal alternatives, endodontic filling also uses ingredients that have antibacterial potential that can kill and prevent reproduction in the root canals, one of which is the zinc oxide eugenol sealer which is usually applied together with gutta percha. Research objective: to determine the effectiveness of the extract of tamarillo (Solanum betaccum Cav.) skin sealer combination in inhibiting the growth of Enterococcus faecalis. Method: The research was conducted in an experimental laboratory post test only control group design. Results : a sealer made from zinc oxide-eugenol had the largest diameter compared to the combination group of 100%, 75%, 50%, 25% tamarillo skin extract with sealer, and aquadest. Based on the One Way Anova test, there was a significant difference in the mean diameter of the inhibition zone (p <0.05) and the Post Hoc LSD analysis test showed that the sealer was the best group to kill the Enterococcus faecalis bacteria. Conclusion : sealers have a good effect on inhibiting Enterococcus faecalis bacteria as a cause of failure in endodontic treatment.

Covid-19 Infection in Elderly with Comorbids

The senior population has a higher risk of contracting Covid-19 and is at risk ofdeveloping more severe disease. This is due to physiological changes in old age,which causes a decrease in immune function accompanied by an increase incomorbid disorders such as diabetes, hypertension, heart disease, lung disease,and dementia. WHO reports that the mortality rate for Covid-19 patients in theelderly above 80 years in China is around 21.9%, Italy is about 89% at the ageabove 70 years, and the United States is 85% at the age of 65 years and over.Delirium syndrome often appears as the primary complaint or infrequently; itoccurs on the first day the patient is treated and shows fluctuating symptoms.Symptoms of delirium, such as disorientation, difficulty concentrating, andinattention, often occur in the elderly and are associated with a poor prognosis.Management of geriatric patients with covid 19 must be carried out thoroughlyand completely, especially in geriatric patients with comorbidities. Managementincludes primary diseases, namely Covid-19 infection, delirium, nutritionaltherapy, blood sugar, family education for patient assistance, maintaining thepatient's body and environment cleanliness, oral hygiene, and, last but not least,moral support from the family for the patient. With complete management, elderlypatients with various comorbid can survive the Covid-19 infection.