A comparison of magnetic resonance imaging and cardiac biopsy in the evaluation of heart iron overload in patients with beta-thalassemia major

2005 ◽  
Vol 75 (3) ◽  
pp. 241-247 ◽  
Author(s):  
Sophie I. Mavrogeni ◽  
Vyron Markussis ◽  
Loukas Kaklamanis ◽  
Dimitrios Tsiapras ◽  
Ioannis Paraskevaidis ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Iron Overload ◽  
Thalassemia Major ◽  
Beta Thalassemia ◽  
Resonance Imaging ◽  
Beta Thalassemia Major

scholarly journals Serum ferritin levels and it’s correlation with cardiac iron overload with the help of cardiac T2* magnetic resonance imaging

2021 ◽  
Vol 8 (8) ◽  
pp. 1374
Author(s):  
Shailaja V. Mane ◽  
Sharad Agarkhedkar ◽  
Dyaneshwar Upase ◽  
Tushar Kalekar ◽  
P. Sindhura
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Iron Overload ◽  
Serum Ferritin ◽  
Ferritin Level ◽  
Thalassemia Major ◽  
Beta Thalassemia ◽  
Resonance Imaging ◽  
Mortality And Morbidity ◽  
T2 Mri

Background: Frequent blood transfusions in thalassemia major is associated with iron overload in these patients. To reduce the mortality and morbidity, proper usage of iron chelators is necessary to treat iron overload. Cardiac magnetic resonance imaging (MRI) guides in quantification of iron overload in heart. The purpose of this study is to see the correlation between serum ferritin level and T2* MRI in patients with beta thalassemia major.Methods: Period of the study is September 2018 to September 2020. Total 25 patients diagnosed with β-thalassemia major above 5 years of age were enrolled in the study. They were on regular transfusions. Cardiac T2* MRI was done in these patients and correlated with serum ferritin levels.Results: There was no significant correlation observed between cardiac T2* MRI and serum ferritin values (p=0.66, r=-0.094).Conclusions: Our results showed no significant correlation between serum ferritin and cardiac T2* MRI values. Ferritin alone cannot be used as index of myocardial iron overload in thalassemia major.

scholarly journals Evaluation of cardiac and hepatic iron overload in thalassemia major patients with T2* magnetic resonance imaging

Hematology ◽  
2017 ◽  
pp. 1-7 ◽  
Author(s):  
Pustika Amalia Wahidiyat ◽  
Felix Liauw ◽  
Damayanti Sekarsari ◽  
Siti Ayu Putriasih ◽  
Vasili Berdoukas ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Iron Overload ◽  
Thalassemia Major ◽  
Hepatic Iron ◽  
Resonance Imaging ◽  
Hepatic Iron Overload

Magnetic resonance imaging in the evaluation of iron overload: a comparison of MRI, echocardiography and serum ferritin level in patients with β-thalassemia major

2012 ◽  
Vol 36 (5) ◽  
pp. 483-488 ◽  
Author(s):  
Bibi Shahin Shamsian ◽  
Shadi Abdar Esfahani ◽  
Hani Milani ◽  
Shahram Akhlaghpoor ◽  
Saeid Mojtahedzadeh ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Iron Overload ◽  
Serum Ferritin ◽  
Serum Ferritin Level ◽  
Ferritin Level ◽  
Thalassemia Major ◽  
Resonance Imaging

scholarly journals R2* magnetic resonance imaging of the liver in patients with iron overload

Blood ◽  
2009 ◽  
Vol 113 (20) ◽  
pp. 4853-4855 ◽  
Author(s):  
Jane S. Hankins ◽  
M. Beth McCarville ◽  
Ralf B. Loeffler ◽  
Matthew P. Smeltzer ◽  
Mihaela Onciu ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Iron Overload ◽  
Bone Marrow Failure ◽  
Intraclass Correlation ◽  
Correlation Coefficients ◽  
Dry Weight ◽  
Thalassemia Major ◽  
Resonance Imaging ◽  
Mri Measurements

R2* magnetic resonance imaging (R2*-MRI) can quantify hepatic iron content (HIC) by noninvasive means but is not fully investigated. Patients with iron overload completed 1.5T R2*-MRI examination and liver biopsy within 30 days. Forty-three patients (sickle cell anemia, n = 32; β-thalassemia major, n = 6; and bone marrow failure, n = 5) were analyzed: median age, 14 years, median transfusion duration, 15 months, average (±SD) serum ferritin 2718 plus or minus 1994 ng/mL, and average HIC 10.9 plus or minus 6.8 mg Fe/g dry weight liver. Regions of interest were drawn and analyzed by 3 independent reviewers with excellent agreement of their measurements (intraclass correlation coefficient = 0.98). Ferritin and R2*-MRI were weakly but significantly associated (range of correlation coefficients among the 3 reviewers, 0.41-0.48; all P < .01). R2*-MRI was strongly associated with HIC for all 3 reviewers (correlation coefficients, 0.96-0.98; all P < .001). This high correlation confirms prior reports, calibrates R2*-MRI measurements, and suggests its clinical utility for predicting HIC using R2*-MRI. This study was registered at www.clinicaltrials.gov as #NCT00675038.

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