Low incidence and severity of graft-versus-host disease after outpatient allogeneic peripheral blood stem cell transplantation employing a reduced-intensity conditioning

2011 ◽  
Vol 87 (6) ◽  
pp. 521-530 ◽  
Author(s):  
Olga G. Cantú-Rodríguez ◽  
César H. Gutiérrez-Aguirre ◽  
José C. Jaime-Pérez ◽  
Oscar R. Treviño-Montemayor ◽  
Sylvia A. Martínez-Cabriales ◽  
...  
Keyword(s):  
Stem Cell ◽  
Stem Cell Transplantation ◽  
Graft Versus Host Disease ◽  
Peripheral Blood ◽  
Peripheral Blood Stem Cell ◽  
Reduced Intensity Conditioning ◽  
Graft Versus Host ◽  
Low Incidence ◽  
Blood Stem Cell Transplantation ◽  
Reduced Intensity

scholarly journals Secondary Squamous Cell Carcinoma of the Tongue Complicated with Bronchiolitis Obliterans as a Manifestation of Graft-versus-Host Disease following Peripheral Blood Stem Cell Transplantation

2019 ◽  
Vol 2019 ◽  
pp. 1-4
Author(s):  
Kengo Hashimoto ◽  
Toru Nagao ◽  
Shin Koie ◽  
Satoru Miyabe ◽  
Terumi Saito
Keyword(s):  
Squamous Cell Carcinoma ◽  
Stem Cell ◽  
Stem Cell Transplantation ◽  
Graft Versus Host Disease ◽  
Peripheral Blood ◽  
Bronchiolitis Obliterans ◽  
Peripheral Blood Stem Cell ◽  
Graft Versus Host ◽  
History Of ◽  
Blood Stem Cell Transplantation

Peripheral blood stem cell transplantation (PBSCT) has increasingly been used for hematologic cancer therapy, resulting in improved survival rates. However, risks include graft-versus-host disease (GVHD) and secondary solid tumors. Here, we describe a case of tongue squamous cell carcinoma (SCC) complicated by bronchiolitis obliterans (BO) following PBSCT. A 42-year-old man with a history of acute lymphocytic leukemia treated with PBSCT presented with multiple white lesions and erosions on the tongue and buccal mucosa that are compatible with oral chronic GVHD (NIH criteria: score 2). The lesions were presented for 8 years. The patient had a history of BO manifested as GVHD. During follow-up, an exophytic mass was rapidly developed on the left dorsum of the tongue. Biopsy of this lesion confirmed SCC (cT2N0M0). Pulmonary function testing for general anesthesia was almost normal. Hemiglossectomy, supraomohyoid neck dissection, and tongue reconstruction were performed. Thirteen months after surgery, the patient showed neither recurrence of tumor nor progression of oral GVHD. However, the patient died of respiratory failure due to repeated pneumothoraxes and deterioration of BO.

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