The mode of action of prostaglandin (PG) I1 analog, SM-10906, on fibroblasts of hypertrophic scars is similar to PGE1 in its potential role of preventing scar formation

1997 ◽  
Vol 6 (6) ◽  
pp. 314-320 ◽  
Author(s):  
L.-J. Zhou ◽  
M. Inone ◽  
I. Ono ◽  
F. Kaneko
Keyword(s):  
Mode Of Action ◽  
Potential Role ◽  
Scar Formation ◽  
Hypertrophic Scars

scholarly journals Potential role of Plasmodium falciparum exported protein 1 in the chloroquine mode of action

2018 ◽  
Vol 8 (1) ◽  
pp. 31-35 ◽  
Author(s):  
Andreas Martin Lisewski ◽  
Joel Patrick Quiros ◽  
Monica Mittal ◽  
Nagireddy Putluri ◽  
Arun Sreekumar ◽  
...  
Keyword(s):  
Plasmodium Falciparum ◽  
Mode Of Action ◽  
Potential Role ◽  
Exported Protein

scholarly journals The role of macrophages in the formation of hypertrophic scars and keloids

2020 ◽  
Vol 8 ◽  
Author(s):  
Xiangwen Xu ◽  
Shuchen Gu ◽  
Xin Huang ◽  
Jieyi Ren ◽  
Yihui Gu ◽  
...  
Keyword(s):  
Late Stage ◽  
Early Stage ◽  
Scar Formation ◽  
M2 Macrophages ◽  
Hypertrophic Scars ◽  
Prediction And Prevention ◽  
Invasive Property ◽  
Pathological Scar ◽  
M1 And M2 Macrophages

Abstract Numerous studies have shown that macrophages can orchestrate the microenvironment from the early stage of wound healing to the later stages of scar formation. However, few reviews have highlighted the significance of macrophages during the formation of abnormal scars. The purpose of this review was to outline the polarization of macrophages from early to late stage of pathological scar formation, focusing on spatiotemporal diversity of M1 and M2 macrophages. In this review, the role of macrophages in the formation of hypertrophic scars and keloids is summarized in detail. First, an increased number of M2 cells observed before injuries are significantly associated with susceptibility to abnormal scar pathogenesis. Second, decreased expression of M1 at the early stage and delayed expression of M2 at the late stage results in pathological scar formation. Third, M2 cells are highly expressed at both the margin and the superficial region, which is consistent with the invasive property of keloids. Finally, this review helps to characterize strategies for the prediction and prevention of pathological scar formation.

POPDC proteins and cardiac function

2019 ◽  
Vol 47 (5) ◽  
pp. 1393-1404 ◽  
Author(s):  
Thomas Brand
Keyword(s):  
Potential Role ◽  
Striated Muscle ◽  
Short Review ◽  
Effector Proteins ◽  
Muscle Disease ◽  
Disease Genes ◽  
Protein Protein Interaction ◽  
Interaction Partners ◽  
And Function

Abstract The Popeye domain-containing gene family encodes a novel class of cAMP effector proteins in striated muscle tissue. In this short review, we first introduce the protein family and discuss their structure and function with an emphasis on their role in cyclic AMP signalling. Another focus of this review is the recently discovered role of POPDC genes as striated muscle disease genes, which have been associated with cardiac arrhythmia and muscular dystrophy. The pathological phenotypes observed in patients will be compared with phenotypes present in null and knockin mutations in zebrafish and mouse. A number of protein–protein interaction partners have been discovered and the potential role of POPDC proteins to control the subcellular localization and function of these interacting proteins will be discussed. Finally, we outline several areas, where research is urgently needed.

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