A critical review on the potential role of adipose‐derived stem cells for future treatment of hypertrophic scars

2021 ◽  
Author(s):  
Karina Teja Putri ◽  
Theddeus Octavianus Hari Prasetyono
Keyword(s):  
Stem Cells ◽  
Critical Review ◽  
Potential Role ◽  
Adipose Derived Stem Cells ◽  
Hypertrophic Scars ◽  
Future Treatment

scholarly journals Oncogenic Linear Collagen VI of Invasive Breast Cancer Is Induced by CCL5

2020 ◽  
Vol 9 (4) ◽  
pp. 991 ◽  
Author(s):  
Elizabeth Brett ◽  
Matthias Sauter ◽  
Éadaoin Timmins ◽  
Omid Azimzadeh ◽  
Michael Rosemann ◽  
...  
Keyword(s):  
Stem Cells ◽  
Extracellular Matrix ◽  
Potential Role ◽  
Dermal Fibroblasts ◽  
Adipose Derived Stem Cells ◽  
Mechanism Of Formation ◽  
Collagen Vi

The triple-negative breast tumor boundary is made of aligned, linear collagen. The pro-oncogenic impact of linear collagen is well established; however, its mechanism of formation is unknown. An in vitro analogue of the tumor border is created by a co-culture of MDA-MB-231 cells, adipose derived stem cells, and dermal fibroblasts. Decellularization of this co-culture after seven days reveals an extracellular matrix that is linear in fashion, high in pro-oncogenic collagen type VI, and able to promote invasion of reseeded cells. Further investigation revealed linear collagen VI is produced by fibroblasts in response to a paracrine co-culture of adipose derived stem cells and MDA-MB-231, which together secrete high levels of the chemokine CCL5. The addition of monoclonal antibody against CCL5 to the co-culture results in an unorganized matrix with dramatically decreased collagen VI. Importantly, reseeded cells do not exhibit pro-oncogenic behavior. These data illustrate a cellular mechanism, which creates linear extracellular matrix (ECM) in vitro, and highlight a potential role of CCL5 for building striated tumor collagen in vivo.

scholarly journals The regenerative role of adipose-derived stem cells (ADSC) in plastic and reconstructive surgery

2016 ◽  
Vol 14 (1) ◽  
pp. 112-124 ◽  
Author(s):  
Naghmeh Naderi ◽  
Emman J Combellack ◽  
Michelle Griffin ◽  
Tina Sedaghati ◽  
Muhammad Javed ◽  
...  
Keyword(s):  
Stem Cells ◽  
Reconstructive Surgery ◽  
Adipose Derived Stem Cells ◽  
Plastic And Reconstructive Surgery

Stem Cells from Human Exfoliated Deciduous Teeth and their Promise as Preventive and Therapeutic Strategies for Neurological Diseases and Injuries

2021 ◽  
Vol 17 ◽  
Author(s):  
Lingyi Huang ◽  
Zizhuo Zheng ◽  
Ding Bai ◽  
Xianglong Han
Keyword(s):  
Stem Cells ◽  
Potential Role ◽  
Neurological Diseases ◽  
Therapeutic Strategies ◽  
Deciduous Teeth ◽  
Research Attention ◽  
Considerable Potential ◽  
Prevention And Treatment ◽  
Human Exfoliated Deciduous Teeth

Abstract: Stem cells from human exfoliated deciduous teeth (SHEDs) are relatively easy to isolate from exfoliated deciduous teeth, which are obtained via dental therapy as biological waste. SHEDs originate from the embryonic neural crest and therefore have considerable potential for neurogenic differentiation. Currently, an increasing amount of research attention is focused on the therapeutic applications of SHEDs in neurological diseases and injuries. In this article, we summarize the biological characteristics of SHEDs and the potential role of SHEDs and their derivatives, including conditioned medium from SHEDs and the exosomes they secrete, in the prevention and treatment of neurological diseases and injuries.

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