Transmembrane Signals and Intracellular "Second Messengers" in the Regulation of Quiescent B-Lymphocyte Activation

1987 ◽  
Vol 95 (1) ◽  
pp. 37-57 ◽  
Author(s):  
JohnC. Cambier ◽  
LouisB. Justement ◽  
M. KarenNewell ◽  
ZhengZ. Chen ◽  
LesleyK. Harris ◽  
...  
Keyword(s):  
B Lymphocyte ◽  
Second Messengers ◽  
Lymphocyte Activation ◽  
B Lymphocyte Activation ◽  
Intracellular Second Messengers

Regulation of B-lymphocyte activation by the PH domain adaptor protein Bam32/DAPP1

2007 ◽  
Vol 35 (2) ◽  
pp. 181-182 ◽  
Author(s):  
A.J. Marshall ◽  
T. Zhang ◽  
M. Al-Alwan
Keyword(s):  
B Cell ◽  
B Lymphocyte ◽  
Second Messengers ◽  
Lymphocyte Activation ◽  
Adaptor Protein ◽  
Cell Receptor ◽  
Pleckstrin Homology Domain ◽  
Ph Domain ◽  
B Lymphocyte Activation ◽  
Signal Transduction Proteins

PI3Ks (phosphoinositide 3-kinases) play critical roles in BCR (B-cell receptor) signalling via the generation of 3-phosphoinositide second messengers. Recruitment of PH domain (pleckstrin homology domain)-containing signal transduction proteins to the plasma membrane through binding to 3-phosphoinositide second messengers represents a major effector mechanism for PI3Ks. Here, we review data on the PH domain-containing adaptor protein Bam32 (B-cell adaptor molecule of 32 kDa)/DAPP1 (dual adaptor for phosphotyrosine and 3-phosphoinositides 1), focusing on its functions in B-lymphocyte activation. Present results support the view that Bam32/DAPP1 mediates multiple PI3K-dependent responses in B-cells through membrane-proximal mechanisms involving Src kinases, Rac1, F-actin and mitogen-activated protein kinases, resulting in selective effects on BCR-mediated proliferation, antigen presentation and generation of antibody responses.

Effects of Zidovudine on B Lymphocyte Activation

1994 ◽  
Vol 158 (1) ◽  
pp. 140-156 ◽  
Author(s):  
Daniel Widney ◽  
Sigal Yawetz ◽  
Meta van der Meyden ◽  
Steven A. Miles ◽  
Tadamitsu Kishimoto ◽  
...  
Keyword(s):  
B Lymphocyte ◽  
Lymphocyte Activation ◽  
B Lymphocyte Activation

B lymphocyte activation

1981 ◽  
Vol 2 (9) ◽  
pp. 181-184 ◽  
Author(s):  
Göran Möller
Keyword(s):  
B Lymphocyte ◽  
Lymphocyte Activation ◽  
B Lymphocyte Activation

Suppression of human B lymphocyte activation by ß-endorphin

1990 ◽  
Vol 28 (3) ◽  
pp. 209-217 ◽  
Author(s):  
Edward L. Morgan ◽  
Michael R. McClurg ◽  
Jodee A. Janda
Keyword(s):  
B Lymphocyte ◽  
Lymphocyte Activation ◽  
B Lymphocyte Activation

scholarly journals Genetic Control of T and B Lymphocyte Activation in Nonobese Diabetic Mice

2001 ◽  
Vol 167 (12) ◽  
pp. 7169-7179 ◽  
Author(s):  
Priscilla P. L. Chiu ◽  
Anthony M. Jevnikar ◽  
Jayne S. Danska
Keyword(s):  
Genetic Control ◽  
B Lymphocyte ◽  
Lymphocyte Activation ◽  
Diabetic Mice ◽  
Nonobese Diabetic ◽  
B Lymphocyte Activation ◽  
Nonobese Diabetic Mice
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