The Effect of Long-Term Corticosteroid Therapy on Haemoglobin, Red-Cell Values and Red-Cell Indices in Children with Bronchial Asthma

Concentrations of the immunoglobulin that is associated with reaginic activity, IgE (γE), were measured in sera of 116 children with bronchial asthma. High γE (>700 ng/ml) were found in only 30. High γE levels were found in children with many positive skin tests (P < 0.01) and with active atopic dermatitis (P < 0.01). Long term, systemic corticosteroid therapy was found to be associated with normal γE values (P < .001) even when the characteristics of the disease would otherwise have indicated high values. As no correlation is found to be evident between severity of the disease and γE levels, it may be suggested that corticosteroids may decrease intravascular γE. The serum γE values failed to reveal two or more clinically different groups among our patients.

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The Effect of Long-Term Corticosteroid Therapy on Total Red-Cell Volume and Haemoglobin Mass in Asthmatic Children

Acta Paediatrica ◽

10.1111/j.1651-2227.1964.tb07220.x ◽

1964 ◽

Vol 53 (2) ◽

pp. 143-148 ◽

Cited By ~ 4

Author(s):

K. N. AGARWAL ◽

L. E. BRATTEBY

Keyword(s):

Cell Volume ◽

Corticosteroid Therapy ◽

Red Cell ◽

Red Cell Volume ◽

Asthmatic Children ◽

Haemoglobin Mass

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PITUITARY-ADRENAL RECOVERY FOLLOWING LONG-TERM CORTICOSTEROID THERAPY

Acta Endocrinologica ◽

10.1530/acta.0.0510063 ◽

1966 ◽

Vol 51 (1) ◽

pp. 63-70 ◽

Cited By ~ 4

Author(s):

P. F. Roe ◽

D. M. Mitchell ◽

G. W. Pennington

Keyword(s):

Corticosteroid Therapy ◽

Adrenocortical Function ◽

Endocrine Disorders ◽

Marked Rise ◽

Underlying Condition ◽

Normal Limits ◽

Small Rise ◽

The Mean ◽

Corticosteroid Drugs

ABSTRACT Adrenocortical function was assessed in 20 patients receiving long-term corticosteroid drugs for a variety of non-endocrine disorders. In all cases plasma 17-hydroxycorticosteroids (17-OHCS) levels were within or above normal limits 48 hours after abruptly stopping their drugs and a further marked rise occurred in 7 patients given metyrapone for 24 h. Urinary 17-OHCS excretion did not show a parallel rise. Taking the group as a whole, a small rise in the mean output occurred 48 hours after stopping therapy, and a further slightly greater rise followed metyrapone. 3 patients had a relapse of their underlying condition during the test in spite of normal plasma and urinary 17-OHCS levels.

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Posterior Uveal Effusion after Cataract Surgery

Case Reports in Ophthalmology ◽

10.1159/000510390 ◽

2021 ◽

pp. 62-67

Author(s):

Annegret Abaza ◽

Özlem Dikmetas ◽

Irmingard Neuhann ◽

Faik Gelisken

Keyword(s):

Cataract Surgery ◽

Corticosteroid Therapy ◽

Anterior Segment ◽

Subretinal Fluid ◽

Posterior Pole ◽

Functional Improvement ◽

Long Term Observation ◽

The Right ◽

Uveal Effusion

We report a case of posterior uveal effusion (UE) with a long-term follow-up that has occurred following cataract surgery. A 64-year-old woman presented with diminished vision of the right eye (RE) 3 weeks after an uneventful phacoemulsification and intraocular lens implantation. Complete ophthalmic examination including fluorescein angiography (FA), indocyanine green angiography (ICGA), echography and optical coherence tomography (OCT) were performed. Best corrected visual acuity (BCVA) of the RE was 20/50. Anterior segment and intraocular pressure were unremarkable. OCT revealed prominent folds of the choroid and retina, subretinal fluid and darkening of the choroid with reduced visibility of the choroidal vessels and the scleral border. The left eye (LE) was unremarkable. BCVA of the LE was: 20/20. After topical anti-inflammatory and systemic corticosteroid therapy for 5 months, no morphological change of the macula was seen. The patient was observed without any treatment. Forty-three months after the cataract surgery and 38 months after cessation of the corticosteroid therapy, OCT revealed a normal macular morphology and the BCVA improved to 20/25. Even though rare, UE at the posterior pole may occur after modern cataract surgery. OCT examination is a reliable tool in monitoring the macular morphology. Since morphological and functional improvement can be seen in long-term, observation may be considered for some cases of posterior UE with resistance to the therapy.

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Combined oral pulse and topical corticosteroid therapy for severe alopecia areata in children: a long-term follow-up study

Dermatologic Therapy ◽

10.1111/dth.12255 ◽

2015 ◽

Vol 28 (5) ◽

pp. 309-317 ◽

Cited By ~ 13

Author(s):

Jovan Lalosevic ◽

Mirjana Gajic-Veljic ◽

Branka Bonaci-Nikolic ◽

Milos Nikolic

Keyword(s):

Topical Corticosteroid ◽

Corticosteroid Therapy ◽

Alopecia Areata ◽

Follow Up Study ◽

Long Term Follow Up

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Efficacy and Long-Term Outcome of Treatment for Pure Red Cell Aplasia after Allogeneic Stem Cell Transplantation from Major ABO-Incompatible Donors

Biology of Blood and Marrow Transplantation ◽

10.1016/j.bbmt.2013.04.004 ◽

2013 ◽

Vol 19 (7) ◽

pp. 1026-1032 ◽

Cited By ~ 16

Author(s):

Makoto Hirokawa ◽

Takahiro Fukuda ◽

Kazuteru Ohashi ◽

Michihiro Hidaka ◽

Tatsuo Ichinohe ◽

...

Keyword(s):

Stem Cell ◽

Stem Cell Transplantation ◽

Cell Transplantation ◽

Allogeneic Stem Cell Transplantation ◽

Pure Red Cell Aplasia ◽

Red Cell ◽

Term Outcome ◽

Long Term Outcome ◽

Red Cell Aplasia

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When to try alternate-day corticosteroid therapy

Drug and Therapeutics Bulletin ◽

10.1136/dtb.14.13.49 ◽

1976 ◽

Vol 14 (13) ◽

pp. 49-51

Keyword(s):

Corticosteroid Therapy ◽

Growth Retardation ◽

Water Retention ◽

Muscle Wasting ◽

Oral Corticosteroid ◽

Cortical Atrophy ◽

Children Obesity ◽

Daily Dose ◽

Pituitary Suppression

Treatment with a corticosteroid aims to achieve the remission of disease or satisfactory relief of symptoms with the least unwanted effects. With continuous long-term corticosteroid therapy these include adrenal cortical atrophy due to hypothalamic-pituitary suppression, growth retardation in children, obesity, Cushingoid appearance, bruising, muscle wasting and weakness, osteoporosis, sodium and water retention, diabetes and cataracts. Some of these are inevitable if the daily dose exceeds 10 mg of prednisolone or its equivalent, but the risk can be reduced by giving the drug on alternate days.1a b This regimen is not mentioned in most data sheets for oral corticosteroid preparations.

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Failure of prolonged exercise training to increase red cell mass in humans

AJP Heart and Circulatory Physiology ◽

10.1152/ajpheart.1996.270.1.h121 ◽

1996 ◽

Vol 270 (1) ◽

pp. H121-H126 ◽

Cited By ~ 4

Author(s):

J. K. Shoemaker ◽

H. J. Green ◽

J. Coates ◽

M. Ali ◽

S. Grant

Keyword(s):

Exercise Training ◽

Prolonged Exercise ◽

Cell Mass ◽

Hemoglobin Concentration ◽

Red Cell ◽

Total Blood ◽

Mean Cell Volume ◽

Red Cell Mass ◽

Mean Cell Hemoglobin

The purpose of this study was to investigate the time-dependent effects of long-term prolonged exercise training on vascular volumes and hematological status. Training using seven untrained males [age 21.1 +/- 1.4 (SE) yr] initially consisted of cycling at 68% of peak aerobic power (VO2peak) for 2 h/day, 4-5 days/wk, for 11 wk. Absolute training intensity was increased every 3 wk. Red cell mass (RCM), obtained using 51Cr, was unchanged (P > 0.05) with training (2,142 +/- 95, 2,168 +/- 86, 2,003 +/- 112, and 2,080 +/- 116 ml at 0, 3, 6, and 11 wk, respectively) as were serum erythropoietin levels (17.1 +/- 4.3, 13.9 +/- 3.5, and 17.0 +/- 2.0 U/l at 0, 6, and 11 wk, respectively). Plasma volume measured with 125I-labeled albumin and total blood volume (TBV) were also not significantly altered. The increase in mean cell volume that occurred with training (89.7 +/- 0.95 vs. 91.0 +/- 1.0 fl, 0 vs. 6 wk, P < 0.05) was not accompanied by changes in either mean cell hemoglobin or mean cell hemoglobin concentration. Serum ferritin was reduced 73% with training (67.4 +/- 13 to 17.9 +/- 1 microgram/l, 0 vs. 11 wk, P < 0.05). Total hemoglobin (HbTot) calculated as the product of hemoglobin concentration and TBV was unaltered (P > 0.05) at both 6 and 11 wk of training. The 15% increase in VO2peak (3.39 +/- 0.16 to 3.87 +/- 0.14 l/min, 0 vs. 11 wk, P < 0.05) with training occurred despite a failure of training to change TBV, RCM, or HbTot.

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Response of breeding sows to long term dietary supplementation with folic acid

Proceedings of the British Society of Animal Production (1972) ◽

10.1017/s0308229600026982 ◽

1994 ◽

Vol 1994 ◽

pp. 153-153

Author(s):

P.B. Lynch ◽

P.J.A. Sheehy

Keyword(s):

Folic Acid ◽

Dietary Supplementation ◽

Red Cell ◽

Restricted Feeding ◽

Meat And Bone Meal ◽

Bone Meal ◽

Soyabean Meal ◽

Dietary Treatments

Dietary supplementation with folic acid has been shown to improve reproductive performance in sows (Lindemann 1993). However most studies have been for one cycle only and few have examined the effect of supplementation over several parities.One hundred and thirty four crossbred sows ranging in parity from 2 to 4 were selected at farrowing and randomly allocated to two dietary treatments of low and high supplemental folic acid (0 and 10 g per tonne, Roche Products Ltd.). Treatments were applied for the following three lactations and post weaning periods, two full pregnancies and to day 30 of the pregnancy following the third lactation. The diet fed contained barley, wheat, soyabean meal and meat and bone meal with nutrient levels of 14.0 MJ DE/kg and 1.02% lysine. Sows were individually penned throughout with restricted feeding in pregnancy (2.2 kg/day increasing to 2.5 kg/day in the final month), and ad libitum in lactation (approx 5.0 kg/day) and post weaning (approx 3.4 kg/day). Blood samples for determination of plasma and red cell folate were taken from 14 sows per treatment on days 4, 50 and 110 of one cycle. These were determined by a microbiological assay (modification of methods of Scott et al 1974 and Wilson and Home 1982).

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