Efficacy and safety during long-term treatment f primary monosymptomatic nocturnal enuresis with desmopressin

2007 ◽  
Vol 88 (11) ◽  
pp. 1274-1278 ◽  
Author(s):  
K Tullus ◽  
R Bergström ◽  
I Fosdal ◽  
I Winnergård ◽  
K Hjälmås ◽  
...  
Keyword(s):  
Nocturnal Enuresis ◽  
Term Treatment ◽  
Efficacy And Safety ◽  
Long Term Treatment ◽  
Monosymptomatic Nocturnal Enuresis ◽  
Primary Monosymptomatic Nocturnal Enuresis

Efficacy and safety of long-term treatment with monthly calcifediol soft capsules in vitamin D deficient patients

2021 ◽  
Author(s):  
Jódar Esteban ◽  
Jose Luis Perez-Castrillon ◽  
Dueñas Antonio ◽  
Gonzalo Hernandez ◽  
Nieves Fernandez ◽  
...  
Keyword(s):  
Vitamin D ◽  
Term Treatment ◽  
Efficacy And Safety ◽  
Long Term Treatment

Glucosamine Long-Term Treatment and the Progression of Knee Osteoarthritis: Systematic Review of Randomized Controlled Trials

2005 ◽  
Vol 39 (6) ◽  
pp. 1080-1087 ◽  
Author(s):  
Nalinee Poolsup ◽  
Chutamanee Suthisisang ◽  
Patchareeya Channark ◽  
Wararat Kittikulsuth
Keyword(s):  
Knee Osteoarthritis ◽  
Disease Progression ◽  
Term Treatment ◽  
Glucosamine Sulfate ◽  
Controlled Trials ◽  
Efficacy And Safety ◽  
Knee Oa ◽  
Randomized Controlled ◽  
Long Term Treatment

OBJECTIVE: To investigate the structural and symptomatic efficacy and safety of glucosamine in knee osteoarthritis (OA). DATA SOURCES: Clinical trials of glucosamine were identified through electronic searches (MEDLINE, EMBASE, BIOSIS, EMB review, the Cochrane Library) using the key words glucosamine, osteoarthritis, degenerative joint disease, degenerative arthritis, osteoarthrosis, gonarthrosis, knee, disease progression, and clinical trial. The bibliographic databases were searched from their respective inception dates to August 2004. We also hand-searched reference lists of relevant articles. STUDY SELECTION AND DATA EXTRACTION: Studies were included if they were double-blind, randomized, controlled trials that evaluated oral glucosamine long-term treatment in knee OA; lasting at least one year; and reporting as outcome measures the symptom severity and disease progression as assessed by joint space narrowing. Two authors interpreted data independently. Disagreements were resolved through discussion. DATA SYNTHESIS: Glucosamine sulfate was more effective than placebo in delaying structural progression in knee OA. The risk of disease progression was reduced by 54% (pooled RR 0.46; 95% CI 0.28 to 0.73; p = 0.0011). The number-needed-to-treat was 9 (95% CI 6 to 20). The pooled effect sizes for pain reduction and improvement in physical function were 0.41 (95% CI 0.21 to 0.60; p < 0.0001) and 0.46 (95% CI 0.27 to 0.66; p < 0.0001), respectively, in favor of glucosamine sulfate. Glucosamine sulfate caused no more adverse effects than placebo. CONCLUSIONS: The available evidence suggests that glucosamine sulfate may be effective and safe in delaying the progression and improving the symptoms of knee OA. Due to the sparse data on structural efficacy and safety, further studies are warranted.

Efficacy and safety of N-acetylprocainamide in long-term treatment of ventricular arrhythmias

1983 ◽  
Vol 33 (5) ◽  
pp. 565-576 ◽  
Author(s):  
Arthur J Atkinson ◽  
Juan J L Lertora ◽  
William Kushner ◽  
George C Chao ◽  
Mary Jane Nevin
Keyword(s):  
Ventricular Arrhythmias ◽  
Term Treatment ◽  
Efficacy And Safety ◽  
Long Term Treatment
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