EPIDERMAL CHANGES IN HEAT AND ELECTRICALLY INJURED PIG SKIN

An interesting method for examining structures in g. pig skin has been developed. By modifying an existing technique for splitting skin into its two main components—epidermis and dermis—we can in effect create new surfaces which can be examined with the scanning electron microscope (SEM). Although this method is not offered as a complete substitute for sectioning, it provides the investigator with a means for examining certain structures such as hair follicles and glands intact. The great depth of field of the SEM complements the technique so that a very “realistic” picture of the organ is obtained.

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Cutaneous lipogenesis: precursors utilized by guinea pig skin for lipid synthesis

The Journal of Lipid Research ◽

10.1016/s0022-2275(20)39516-x ◽

1971 ◽

Vol 12 (3) ◽

pp. 347-360

Author(s):

VICTOR R. WHEATLEY ◽

LEONARD T. HODGINS ◽

WILLIAM M. COON ◽

MUTUKUMARA KUMARASIRI ◽

HAROLD BERENZWEIG ◽

...

Keyword(s):

Guinea Pig ◽

Lipid Synthesis ◽

Pig Skin

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Isolation and characterization of proteochondroitin sulfate from pig skin.

Journal of Biological Chemistry ◽

10.1016/s0021-9258(17)37816-x ◽

1979 ◽

Vol 254 (5) ◽

pp. 1614-1620 ◽

Cited By ~ 7

Author(s):

S.P. Damle ◽

F.J. Kieras ◽

W.K. Tzeng ◽

J.D. Gregory

Keyword(s):

Pig Skin ◽

Isolation And Characterization

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Tachykinin receptor subtype that mediates the increase in vascular permeability in guinea pig skin

Life Sciences ◽

10.1016/0024-3205(89)90336-6 ◽

1989 ◽

Vol 44 (16) ◽

pp. 1089-1095 ◽

Cited By ~ 19

Author(s):

Itsuo Iwamoto ◽

Jay A. Nadel

Keyword(s):

Guinea Pig ◽

Vascular Permeability ◽

Receptor Subtype ◽

Tachykinin Receptor ◽

Pig Skin

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Endogenous Opioids and Ruthenium Red Inhibit the Flare Reaction in the Pig Skin by Different Mechanisms

Annals of the New York Academy of Sciences ◽

10.1111/j.1749-6632.1991.tb33156.x ◽

1991 ◽

Vol 632 (1 Substance P a) ◽

pp. 460-463 ◽

Cited By ~ 3

Author(s):

FR-K. PIERAU ◽

R. ERNST ◽

H. SANN ◽

L. BARTHÓ

Keyword(s):

Ruthenium Red ◽

Endogenous Opioids ◽

Pig Skin ◽

Flare Reaction

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Final Report of the Safety Assessment of Kojic Acid as Used in Cosmetics

International Journal of Toxicology ◽

10.1177/1091581810385956 ◽

2010 ◽

Vol 29 (6_suppl) ◽

pp. 244S-273S ◽

Cited By ~ 52

Author(s):

Christina L. Burnett ◽

Wilma F. Bergfeld ◽

Donald V. Belsito ◽

Ronald A. Hill ◽

Curtis D. Klaassen ◽

...

Keyword(s):

Guinea Pig ◽

Safety Assessment ◽

Expert Panel ◽

Kojic Acid ◽

Tumor Promotion ◽

Final Report ◽

Cosmetic Products ◽

Pig Skin ◽

Animal Data ◽

Skin Lightening

Kojic acid functions as an antioxidant in cosmetic products. Kojic acid was not a toxicant in acute, chronic, reproductive, and genotoxicity studies. While some animal data suggested tumor promotion and weak carcinogenicity, kojic acid is slowly absorbed into the circulation from human skin and likely would not reach the threshold at which these effects were seen. The available human sensitization data supported the safety of kojic acid at a use concentration of 2% in leave-on cosmetics. Kojic acid depigmented black guinea pig skin at a concentration of 4%, but this effect was not seen at 1%. The Cosmetic Ingredient Review (CIR) Expert Panel concluded that the 2 end points of concern, dermal sensitization and skin lightening, would not be seen at use concentrations below 1%; therefore, this ingredient is safe for use in cosmetic products up to that level.

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