Treatment Satisfaction with Sildenafil in a Canadian Real-Life Setting. A 6-Month Prospective Observational Study of Primary Care Practices

2007 ◽  
Vol 4 (5) ◽  
pp. 1414-1421 ◽  
Author(s):  
Serge Carrier ◽  
Gerald Brock ◽  
Richard Casey ◽  
Jean-Eric Tarride ◽  
Stacey Elliott ◽  
...  
2021 ◽  
Author(s):  
Stjepan Oreskovic ◽  
Jeffrey H. Ashburner ◽  
Hrvoje Tiljak ◽  
Janez Rifel ◽  
Tin Oreskovic ◽  
...  

Our study aims to implement a smoking cessation program using pharmacotherapy in a real-life setting (primary care practices in Croatia and Slovenia) and to investigate whether cytisine is at least as feasible and effective as Varenicline in helping smokers to quit in a randomized non-inferiority trial. The use of these medications as an intervention tool for smoking cessation in Croatia and Slovenia is not previously explored and the level of awareness and interest in pharmacotherapy among smokers is unknown.


BMJ Open ◽  
2019 ◽  
Vol 9 (5) ◽  
pp. e026464 ◽  
Author(s):  
Rob Bielen ◽  
Özgür M Koc ◽  
Dana Busschots ◽  
Geert Robaeys ◽  
Bert Aertgeerts ◽  
...  

ObjectivesChronic infections with hepatitis B virus (HBV) and hepatitis C virus (HCV) have a major impact on mortality worldwide. Although effective treatments are available for both HBV and HCV infection, <50% of the patients are even diagnosed in Belgium. This study assessed the real-life testing—and diagnosis rate by general practitioners (GPs) in Flanders, Belgium.SettingWe assessed the testing rate for HBV and HCV in 48 primary care practices with electronic medical records linked into one central registry in Flanders, Belgium.ParticipantsThe registry contains data of 440 140 patients over 20 years, which corresponds to 2.2% of the total Flemish population yearly. The primary care practices are distributed across Flanders and the patient population is representative for the distribution of age, gender and socioeconomic status at the community level.ResultsOf 440 140 patients included in the registry, 7892 (1.8%) patients were screened for hepatitis B surface antigen (HBsAg) and 7206 (1.6%) for hepatitis C antibody (HCV Ab) of whom 369 (4.7%) and 163 (2.3%) tested positive, respectively. Of 14 059 patients with chronic liver enzyme elevation, 1112 (7.9%) and 1395 (9.9%) were tested for HBsAg and HCV Ab, respectively. There was no improvement in testing rates over time.ConclusionsThis study demonstrates that real-life testing uptake for viral hepatitis B and C is suboptimal in the general practices in Flanders, even in patients with chronically elevated liver enzymes. As GPs play a crucial role in prevention, diagnosis and linkage to care, efforts and strategies to increase the testing uptake for HBV and HCV are urgently needed.


2013 ◽  
Vol 29 (12) ◽  
pp. 1737-1745
Author(s):  
Gillian C. Hall ◽  
Vian Amber ◽  
Chris O’Regan ◽  
Kevin Jameson

BMJ Open ◽  
2021 ◽  
Vol 11 (4) ◽  
pp. e044691
Author(s):  
Georgia Woodfield ◽  
Ilaria Belluomo ◽  
Piers R Boshier ◽  
Annabelle Waller ◽  
Maya Fayyad ◽  
...  

ObjectivesTo examine the feasibility and acceptability of breath research in primary care.DesignNon-randomised, prospective, mixed-methods cross-sectional observational study.SettingTwenty-six urban primary care practices.Participants1002 patients aged 18–90 years with gastrointestinal symptoms.Main outcome measuresDuring the first 6 months of the study (phase 1), feasibility of patient enrolment using face-to-face, telephone or SMS-messaging (Short Message Service) enrolment strategies, as well as processes for breath testing at local primary care practices, were evaluated. A mixed-method iterative study design was adopted and outcomes evaluated using weekly Plan-Do-Study-Act cycles, focus groups and general practitioner (GP) questionnaires.During the second 6 months of the study (phase 2), patient and GP acceptability of the breath test and testing process was assessed using questionnaires. In addition a ‘single practice’ recruitment model was compared with a ‘hub and spoke’ centralised recruitment model with regards to enrolment ability and patient acceptability.Throughout the study feasibility of the collection of a large number of breath samples by clinical staff over multiple study sites was evaluated and quantified by the analysis of these samples using mass spectrometry.Results1002 patients were recruited within 192 sampling days. Both ‘single practice’ and ‘hub and spoke’ recruitment models were effective with an average of 5.3 and 4.3 patients accrued per day, respectively. The ‘hub and spoke’ model with SMS messaging was the most efficient combined method of patient accrual. Acceptability of the test was high among both patients and GPs. The methodology for collection, handling and analysis of breath samples was effective, with 95% of samples meeting quality criteria.ConclusionsLarge-scale breath testing in primary care was feasible and acceptable. This study provides a practical framework to guide the design of Phase III trials examining the performance of breath testing in primary care.


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