Stereospecific, Organ-Specific Inhibition of Intestinal Alkaline Phosphatase

2006 ◽  
Vol 103 (2) ◽  
pp. 951-955 ◽  
Author(s):  
William H. Fishman ◽  
J. H. Kreisher
Keyword(s):  
Alkaline Phosphatase ◽  
Specific Inhibition ◽  
Intestinal Alkaline Phosphatase ◽  
Organ Specific

L-Phenylalanine inhibition of human alkaline phosphatases with p-nitrophenyl phosphate as substrate.

1982 ◽  
Vol 28 (12) ◽  
pp. 2426-2428 ◽  
Author(s):  
T Komoda ◽  
S Hokari ◽  
M Sonoda ◽  
Y Sakagishi ◽  
T Tamura
Keyword(s):  
Alkaline Phosphatase ◽  
Human Placenta ◽  
Placental Alkaline Phosphatase ◽  
Specific Inhibition ◽  
Human Intestine ◽  
Alkaline Phosphatases ◽  
Substrate Complex ◽  
Nitrophenyl Phosphate ◽  
Organ Specific ◽  
Alkaline Phosphatase Isoenzyme

Abstract With p-nitrophenyl phosphate as the substrate, there reportedly is no organ-specific inhibition of alkaline phosphatase (EC 3.1.3.1) activity by L-phenylalanine. However, we found that at pH 10.0, with p-nitrophenyl phosphate as the substrate, L-phenylalanine obviously inhibits the alkaline phosphatase isoenzyme from human placenta, whereas there is little if any inhibition of the isoenzyme from human intestine. Because of the differing effects of substrates (p-nitrophenyl phosphate and phenyl phosphate) and their enzymic products (p-nitrophenol and phenol) for L-phenylalanine action on the placental alkaline phosphatase isoenzyme, we suggest that the isoenzyme--inhibitor--substrate complex and the effect of released phosphate on L-phenylalanine inhibition of the isoenzyme activity differ from each other.

L-Phenylalanine : an Organ Specific, Stereo-specific Inhibitor of Human Intestinal Alkaline Phosphatase

Nature ◽  
1963 ◽  
Vol 198 (4881) ◽  
pp. 685-686 ◽  
Author(s):  
WILLIAM H. FISHMAN ◽  
SIDNEY GREEN ◽  
NORMA I. INGLIS
Keyword(s):  
Alkaline Phosphatase ◽  
Specific Inhibitor ◽  
Intestinal Alkaline Phosphatase ◽  
Organ Specific

scholarly journals Influence of Secretin and Cholecystokinin on Intestinal Alkaline Phosphatase Secretion

1973 ◽  
Vol 64 (4) ◽  
pp. 599-602 ◽  
Author(s):  
Walter P. Dyck ◽  
George A. Martin ◽  
Charles R. Ratliff
Keyword(s):  
Alkaline Phosphatase ◽  
Intestinal Alkaline Phosphatase

scholarly journals Characterization and comparison of soluble and membranous forms of intestinal alkaline phosphatase from the suckling rat.

1981 ◽  
Vol 256 (11) ◽  
pp. 5620-5626
Author(s):  
S.T. Yedlin ◽  
G.P. Young ◽  
B. Seetharam ◽  
S. Seetharam ◽  
D.H. Alpers
Keyword(s):  
Alkaline Phosphatase ◽  
Intestinal Alkaline Phosphatase

scholarly journals Sequence and characterization of the human intestinal alkaline phosphatase gene.

1988 ◽  
Vol 263 (24) ◽  
pp. 12011-12019 ◽  
Author(s):  
P S Henthorn ◽  
M Raducha ◽  
T Kadesch ◽  
M J Weiss ◽  
H Harris
Keyword(s):  
Alkaline Phosphatase ◽  
Intestinal Alkaline Phosphatase
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