Role of the Basolateral Amygdala in Memory Consolidation

Abstract The role of the basolateral amygdala (BLA) in the consolidation of aversive memory is well established. Here we investigate the involvement of the histaminergic system in BLA on this variable. Rats were chronically implanted with bilateral cannulae in the BLA and after recovery were trained in a one-trial step-down inhibitory avoidance task. Immediately after training histaminergic compounds either alone or in combination were infused through the cannulae. Memory was assessed in test sessions carried out 24 h after the training session. Post-training histamine (1–10 nmol; 0.5 µl/side) enhanced consolidation and the histamine H3 receptor antagonist thioperamide (50 nmol; 0.5 µl/side) impaired memory consolidation. The effect was shared by the histamine N-methyltransferase inhibitor SKF-91844 (50 nmol; 0.5 µl/side) as well as by the H3 receptor agonist imetit (10 nmol; 0.5 µl/side). The promnesic action of histamine was unaffected by the H1 receptor antagonist pyrilamine (50 nmol; 0.5 µl/side). The H1 receptor agonist pyridylethylamine (10 nmol; 0.5 µl/side), the H2 agonist dimaprit (10 nmol; 0.5 µl/side) and the H2 antagonist ranitidine (50 nmol; 0.5 µl/side) were ineffective. Histaminergic compounds infused into the BLA had no effect on open-field or elevated plus-maze behaviour. The data show that histamine induces a dose-dependent mnemonic effect in rats and indicate that this reflects a role of endogenous histamine in the BLA mediated by H3 receptors.

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Enhancement of extinction memory consolidation: The role of the noradrenergic and GABAergic systems within the basolateral amygdala

Neurobiology of Learning and Memory ◽

10.1016/j.nlm.2005.12.008 ◽

2006 ◽

Vol 86 (2) ◽

pp. 123-132 ◽

Cited By ~ 130

Author(s):

D BERLAU ◽

J MCGAUGH

Keyword(s):

Memory Consolidation ◽

Basolateral Amygdala ◽

Extinction Memory

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The role of the basolateral amygdala in stimulus-reward memory and extinction memory consolidation and in subsequent conditioned cued reinstatement of cocaine seeking

European Journal of Neuroscience ◽

10.1111/j.1460-9568.2006.04806.x ◽

2006 ◽

Vol 23 (10) ◽

pp. 2809-2813 ◽

Cited By ~ 64

Author(s):

Rita A. Fuchs ◽

Matthew W. Feltenstein ◽

Ronald E. See

Keyword(s):

Memory Consolidation ◽

Basolateral Amygdala ◽

Cocaine Seeking ◽

Extinction Memory

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Effect of pretreatment with intracerebroventricular injection of minocycline on morphine‐induced memory impairment in passive avoidance test: Role of P‐ CREB and c‐Fos expression in the dorsal hippocampus and basolateral amygdala regions

Clinical and Experimental Pharmacology and Physiology ◽

10.1111/1440-1681.13090 ◽

2019 ◽

Vol 46 (8) ◽

pp. 711-722 ◽

Cited By ~ 2

Author(s):

Shokouh Hamidkhaniha ◽

Hamideh Bashiri ◽

Ameneh Omidi ◽

Ali Hosseini‐Chegeni ◽

Seyed Mohammad Tavangar ◽

...

Keyword(s):

Passive Avoidance ◽

Memory Impairment ◽

Basolateral Amygdala ◽

Dorsal Hippocampus ◽

Passive Avoidance Test ◽

Intracerebroventricular Injection ◽

Avoidance Test ◽

Fos Expression

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Environmental enrichment prevents the late effect of acute stress-induced fear extinction deficit: the role of hippocampal AMPA-GluA1 phosphorylation

Translational Psychiatry ◽

10.1038/s41398-020-01140-6 ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Leonardo Santana Novaes ◽

Letícia Morais Bueno-de-Camargo ◽

Carolina Demarchi Munhoz

Keyword(s):

Environmental Enrichment ◽

Basolateral Amygdala ◽

Acute Stress ◽

Fear Memory ◽

Fear Extinction ◽

Post Traumatic Stress ◽

Related Disorder ◽

Memory Extinction ◽

Post Traumatic

AbstractThe persistence of anxiety and the deficit of fear memory extinction are both phenomena related to the symptoms of a trauma-related disorder, such as post-traumatic stress disorder (PTSD). Recently we have shown that single acute restraint stress (2 h) in rats induces a late anxiety-related behavior (observed ten days after stress), whereas, in the present work, we found that the same stress impaired fear extinction in animals conditioned ten days after stress. Fourteen days of environmental enrichment (EE) prevented the deleterious effect of stress on fear memory extinction. Additionally, we observed that EE prevented the stress-induced increase in AMPA receptor GluA1 subunit phosphorylation in the hippocampus, but not in the basolateral amygdala complex and the frontal cortex, indicating a potential mechanism by which it exerts its protective effect against the stress-induced behavioral outcome.

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