The Cyclobutane Dimers of 2′-Deoxyuridine, 2′-Deoxycytidine, 5-Methyl-2′-Deoxycytidine and 5-Bromo-2′-Deoxyuridine

2012 ◽  
Vol 88 (5) ◽  
pp. 1236-1247 ◽  
Author(s):  
Martin D. Shetlar ◽  
Janet Chung
Keyword(s):  
Cyclobutane Dimers

scholarly journals DNA backbone conformation in cis-syn pyrimidine[]pyrimidine cyclobutane dimers

Biopolymers ◽  
1980 ◽  
Vol 19 (9) ◽  
pp. 1695-1701 ◽  
Author(s):  
S. Broyde ◽  
S. Stellman ◽  
B. Hingerty
Keyword(s):  
Backbone Conformation ◽  
Cyclobutane Dimers ◽  
Dna Backbone ◽  
In Cis

scholarly journals U-U and T-T cyclobutane dimers have different mutational properties

1993 ◽  
Vol 21 (17) ◽  
pp. 4059-4065 ◽  
Author(s):  
Peter E.M. Gibbs ◽  
Christopher W. Lawrence
Keyword(s):  
Cyclobutane Dimers

CHLORANIL-PHOTOSENSITIZED MONOMERIZATION OF DIMETHYLTHYMINE CYCLOBUTANE DIMERS and EFFECT OF MAGNESIUM PERCHLORATE

1990 ◽  
Vol 52 (5) ◽  
pp. 973-979 ◽  
Author(s):  
Chyongjin Pac ◽  
Ikuya Miyamoto ◽  
Yasuhiro Masaki ◽  
Seiichi Furusho ◽  
Shozo Yanagida ◽  
...  
Keyword(s):  
Magnesium Perchlorate ◽  
Cyclobutane Dimers

scholarly journals Requirement of DNA Polymerase η for Error-Free Bypass of UV-Induced CC and TC Photoproducts

2001 ◽  
Vol 21 (1) ◽  
pp. 185-188 ◽  
Author(s):  
Sung-Lim Yu ◽  
Robert E. Johnson ◽  
Satya Prakash ◽  
Louise Prakash
Keyword(s):  
Dna Polymerase ◽  
Uv Light ◽  
Wide Spectrum ◽  
Variant Form ◽  
Induced Mutations ◽  
Uv Mutagenesis ◽  
Genetic Studies ◽  
Human Dna ◽  
Skin Cancers ◽  
Cyclobutane Dimers

ABSTRACT The yeast RAD30-encoded DNA polymerase η (Polη) bypasses a cis-syn thymine-thymine dimer efficiently and accurately. Human DNA polymerase η functions similarly in the bypass of this lesion, and mutations in human Polη result in the cancer prone syndrome, the variant form of xeroderma pigmentosum. UV light, however, also elicits the formation ofcis-syn cyclobutane dimers and (6-4) photoproducts at 5′-CC-3′ and 5′-TC-3′ sites, and in both yeast and human DNA, UV-induced mutations occur primarily by 3′ C to T transitions. Genetic studies presented here reveal a role for yeast Polη in the error-free bypass of cyclobutane dimers and (6-4) photoproducts formed at CC and TC sites. Thus, by preventing UV mutagenesis at a wide spectrum of dipyrimidine sites, Polη plays a pivotal role in minimizing the incidence of sunlight-induced skin cancers in humans.

scholarly journals Two New Cyclobutane Dimers from Diospyros macrocarpa

2017 ◽  
Vol 12 (8) ◽  
pp. 1934578X1701200
Author(s):  
Charlotte Thieury ◽  
Rémy Le Guével ◽  
Gaëtan Herbette ◽  
Valérie Monnier ◽  
Nicolas Lebouvier ◽  
...  
Keyword(s):  
Cancer Cell ◽  
New Caledonia ◽  
Radical Scavenging Activity ◽  
Radical Scavenging ◽  
Cancer Cell Line ◽  
Cytotoxic Activities ◽  
Endemic Plant ◽  
Leaf Extracts ◽  
Phytochemical Study ◽  
Cyclobutane Dimers

A biochemical and phytochemical study of Diospyros macrocarpa Hiern, an endemic plant of New Caledonia, was realized. Indeed, bark and leaf extracts were tested for their cytotoxic and antibiotic activities as well as for their radical scavenging properties. Methanol extracts showed promising radical scavenging activity with an IC50 value of 5.6 ± 0.9 μg/mL for the leaves and 8.1 ± 1.4 μg/mL for the barks. The ethyl acetate extract from the barks showed strong and selective activity against NCI-H727 cancer cell line with an IC50 value of 9.5 ± 0.6 μg/mL.. Two new cyclobutane dimers: macrocarpasin A (1) and B (2) (figure 1) together with six known compounds: yangonin (3), betulinic acid (4), α-amyrin (5), β–amyrin (6), loliolide (7) and oleanderolide (8) were isolated from leaf extracts. Their structures were established by 1D and 2D NMR along with HRMS analyses. Cytotoxic activities of isolated compounds were also evaluated. None of them showed interesting cytotoxicity against the seven tested cancer cell lines.

Sign in / Sign up

Export Citation Format

Share Document