INTESTINAL ADAPTATION TO MASSIVE SMALL-BOWEL RESECTION FOLLOWS TOTAL PARENTERAL NUTRITION SUPPLEMENTED WITH SHORT-CHAIN FATTY ACIDS

2009 ◽  
Vol 47 (9) ◽  
pp. 267-268 ◽  
Keyword(s):  
Fatty Acids ◽  
Small Bowel ◽  
Parenteral Nutrition ◽  
Total Parenteral Nutrition ◽  
Bowel Resection ◽  
Intestinal Adaptation ◽  
Short Chain Fatty Acids ◽  
Small Bowel Resection ◽  
Short Chain ◽  
Massive Small Bowel Resection

scholarly journals Glutamine alone or combined with short-chain fatty acids fails to enhance gut adaptation after massive enterectomy in rats

2006 ◽  
Vol 21 (suppl 4) ◽  
pp. 2-7 ◽  
Author(s):  
José de Souza Neves ◽  
José Eduardo de Aguilar-Nascimento ◽  
Maria Helena Gaiva Gomes-da-Silva ◽  
Rosecélia Nunes Cavalcanti ◽  
Alberto Salomão Bicudo ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Small Bowel ◽  
Intestinal Adaptation ◽  
Short Chain Fatty Acids ◽  
Small Bowel Resection ◽  
Short Chain ◽  
Control Group ◽  
Wall Width ◽  
Morphological Findings ◽  
Chain Fatty Acids

PURPOSE: To investigate the effect of oral glutamine alone or combined with short chain fatty acids (SCFA) in the intestinal adaptation of rats submitted to an massive enterectomy. METHODS: After receiving 70% small bowel resection, 30 Wistar rats were randomized to received either standard rat chow (control group, n=10) or the same diet supplemented with 3,05% of glutamine alone (glutamine group, n=10) or combined with a solution containing SCFA (glutamine+SCFA group, n=10). Animals were killed on the 14th postoperative day. Mucosal weight, crypt depth, villus height, wall width, and the mucosal content of DNA, were assessed in basal conditions (resected gut specimen) and compared to the small bowel specimen collected on the postoperative day 14, at both jejunum and ileum sites. RESULTS: All groups presented similar pattern in weight evolution. In all groups, both the morphological findings and the DNA content were significantly higher at the end of the experiment than in basal conditions, at both the jejunum and ileum. Except for the jejunum wall width that was higher in control group (808±95 µ) than in the other two groups (glutamine = 649±88 µ and glutamine+SCFA = 656±92; p<0.01), there was no difference among them in all variables at both intestinal sites after 14 days. CONCLUSION: All groups presented adaptation of the intestinal mucosa in the remnant gut. Glutamine combined or not with short chain fatty acids fails to influence the adaptive response of the small bowel.

Effect of sex and sex hormones on structural intestinal adaptation after massive small bowel resection in rats

2005 ◽  
Vol 40 (3) ◽  
pp. 489-495 ◽  
Author(s):  
Igor Sukhotnik ◽  
Eitan Shiloni ◽  
Jorge Mogilner ◽  
Michael Lurie ◽  
Mark Hirsh ◽  
...  
Keyword(s):  
Small Bowel ◽  
Sex Hormones ◽  
Bowel Resection ◽  
Intestinal Adaptation ◽  
Small Bowel Resection ◽  
Massive Small Bowel Resection

scholarly journals Colostrum Protein Concentrate Enhances Intestinal Adaptation After Massive Small Bowel Resection in Juvenile Pigs

2004 ◽  
Vol 39 (5) ◽  
pp. 487-492 ◽  
Author(s):  
??va S. Nagy ◽  
Monique C. J. Paris ◽  
Russell G. Taylor ◽  
Peter J. Fuller ◽  
Magdy Sourial ◽  
...  
Keyword(s):  
Small Bowel ◽  
Bowel Resection ◽  
Intestinal Adaptation ◽  
Small Bowel Resection ◽  
Protein Concentrate ◽  
Massive Small Bowel Resection

scholarly journals Parenteral arginine impairs intestinal adaptation following massive small bowel resection in a rat model

2005 ◽  
Vol 21 (6) ◽  
pp. 460-465 ◽  
Author(s):  
Igor Sukhotnik ◽  
Jorge G. Mogilner ◽  
Aaron Lerner ◽  
Arnold G. Coran ◽  
Michael Lurie ◽  
...  
Keyword(s):  
Small Bowel ◽  
Rat Model ◽  
Bowel Resection ◽  
Intestinal Adaptation ◽  
Small Bowel Resection ◽  
Massive Small Bowel Resection
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