Corneal endothelial cells 6-7 years following cataract surgery in patients with pseudoexfoliation syndrome

The effect of pseudoexfoliation syndrome (PEХ) on endothelial cells has been studied long enough. Yet the effect of phacoemulsification (PHACO) on endothelium in patients with PEХ is less explored.Purpose. To assess the impact of PHACO on corneal endothelial cell density (ECD) and on the coefficient of variation (CV) in patients with PEX.Material and methods. 30 patients (30 eyes) with PEX syndrome and 34 patients (34 eyes) with no such syndrome were examined before and after phacoemulsification.Results. In patients with PEX, the ECD after PHACO was significantly lower and CV was significantly higher (р < 0.05).Conclusion. PEX has a negative impact on endothelial cells, which leads to a pronounced cells loss after PHACO.

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Changes in Corneal Endothelial Cells Morphology Due to Different Cataract Surgery Procedures: A Retrospective Study From November 2014 to November 2016

IIUM Medical Journal Malaysia ◽

10.31436/imjm.v17i2.278 ◽

2020 ◽

Vol 17 (2) ◽

Author(s):

Ma Bariah ◽

Leong SY

Keyword(s):

Endothelial Cells ◽

Cataract Surgery ◽

Refractive Error ◽

Central Corneal Thickness ◽

Corneal Thickness ◽

Dissipated Energy ◽

Corneal Endothelial Cells ◽

Significant Difference ◽

Duration Of Surgery ◽

Snellen Chart

Introduction: The corneal endothelium is made up of an extremely thin layer of non -regenerating cells essential in keeping the cornea clear. The purpose of this study was to quantify the corneal endothelial cells morphology, visual acuity (VA) and refractive error in patients having femtosecond laser-assisted cataract surgery (FLACS) and conventional phacoemulsification surgery (CPS). Methods: Clinical data from 56 eyes were included in this study. 28 eyes had FLACS surgery and another 28 eyes had CPS. Distance VA, refractive error, corneal thickness and endothelial cells morphology were evaluated pre-operatively and at 1 month follow up. Refractive error was determined subjectively and VA was taken using Snellen chart. Specular microscope was used to measure endothelial cells morphology and central corneal thickness. Mann Whitney test and Spearman correlation analysis were used to analyse the results. Results: There were no statistically significant difference in the mean endothelial cell density (p=0.24), mean central corneal thickness (p=0.68), mean coefficient of variance (p=0.19), mean hexagonality (p=0.44), VA (p=0.72) and postoperative refractive outcome (p=0.66) between both groups. The duration of surgery was noted to have no statistically significant difference between both groups (p=0.08), while the cumulative dissipated energy and torsional time showed a significant difference between groups (p=0.01 and p<0.01 respectively). Conclusion: This study concluded that there was no significant difference in the endothelial cells morphology in patients undergoing both cataract surgeries. Both surgeries presented similar outcomes in the patients’ eyes.

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Cytotoxicity of Topical Medications Used for Infection and Inflammation Control after Cataract Surgery in Cultured Corneal Endothelial Cells

Biocontrol Science ◽

10.4265/bio.15.97 ◽

2010 ◽

Vol 15 (3) ◽

pp. 97-102 ◽

Cited By ~ 11

Author(s):

MASAHIKO AYAKI ◽

YOKO TAGUCHI ◽

MITSUTAKA SODA ◽

SHIGEO YAGUCHI ◽

ATSUO IWASAWA ◽

...

Keyword(s):

Endothelial Cells ◽

Cataract Surgery ◽

Corneal Endothelial Cells ◽

Infection And Inflammation ◽

Topical Medications

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Comparison of dyes for cataract surgery. Part 1: cytotoxicity to corneal endothelial cells in a rabbit model

American Journal of Ophthalmology ◽

10.1016/j.ajo.2005.08.002 ◽

2005 ◽

Vol 140 (4) ◽

pp. 774

Author(s):

Y.S. Chang ◽

S.Y. Tseng ◽

S.H. Tseng ◽

Y.T. Chen ◽

J.H. Hasiao

Keyword(s):

Endothelial Cells ◽

Cataract Surgery ◽

Rabbit Model ◽

Corneal Endothelial Cells

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Early Postoperative Effects of Uncomplicated Phacoemulsification Surgery on Corneal Endothelial Cells and Thickness in Patients with Pseudoexfoliation Syndrome

10.21203/rs.3.rs-327802/v1 ◽

2021 ◽

Author(s):

EREN EKİCİ ◽

Ali Keles ◽

Süleyman Korhan Kahraman

Keyword(s):

Endothelial Cells ◽

Anterior Chamber ◽

Coefficient Of Variation ◽

Corneal Edema ◽

Pseudoexfoliation Syndrome ◽

Cell Area ◽

Corneal Endothelial Cells ◽

Hexagonal Cell ◽

Significant Group ◽

Cell Ratio

Abstract Purpose: To compare early postoperative effects of uncomplicated phacoemulsification surgery on corneal endothelial cells and thickness in patients with pseudoexfoliation syndrome (PEX).Methods: One eye each of 32 patients with PEX and 32 age-matched non-PEX subjects was evaluated preoperatively and on 1st, 7th, and 30th days after uncomplicated phacoemulsification surgery in this retrospective case-control study. Nuclear firmness, corneal edema (CE), anterior chamber reaction (ACR) intensity were graded by a slit-lamp microscope. Endothelial cell density (ECD), coefficient of variation in cell area (CV), hexagonal cell ratio (HEX), and central corneal thickness (CCT) were measured using a noncontact specular microscope.Results: There was no significant group-difference in age, sex, corneal edema (CE), anterior chamber reaction (ACR), coefficient of variation in cell area (CV), and hexagonal cell ratio (HEX). Mean effective phaco time (EPT) was significantly lower intraoperatively (p<0.001) and logarithm of the minimum angle of resolution (logMAR) values of best-corrected visual acuity (BCVA) were significantly higher on both 1st (p<0.001), 7th (p=0.011), and 30th (p=0.025) days postoperatively in the PEX group than in the non-PEX group. Mean ECD was significantly lower in the PEX group than in the non-PEX group on 7th (p=0.013), and 30th (p=0.037) days postoperatively. The mean CCT significantly differed only on 1st (p<0.001) day postoperatively.Conclusion: Eyes with PEX presented lower corneal ECD and decreased BCVA after uncomplicated phacoemulsification surgery. Further, there was no association between CCT and PEX existence preoperatively and in the early postoperative period.

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