Effect of Solanum trilobatum on hepatic drug metabolising enzymes during diethylnitrosamine-induced hepatocarcinogenesis promoted by Phenobarbital in rat

2007 ◽  
Vol 37 (1) ◽  
pp. 35-49 ◽  
Author(s):  
Moula Shah Jahan ◽  
Ganapathy Vani ◽  
Chennam Srinivasulu Shyamaladevi
Keyword(s):  
Hepatic Drug ◽  
Solanum Trilobatum ◽  
Drug Metabolising Enzymes

Pharmacological Interaction and Combined Toxicity of Exposure to Environmental Chemicals

1989 ◽  
Vol 8 (1-4) ◽  
Author(s):  
Thomothy T. Iyaniwura
Keyword(s):  
Chemical Activation ◽  
Chemical Compounds ◽  
Environmental Chemicals ◽  
Combined Exposure ◽  
Combined Toxicity ◽  
Hepatic Drug ◽  
Pharmacological Interaction ◽  
Mechanisms Of Toxicity ◽  
Endogenous Substances ◽  
Drug Metabolising Enzymes

SummaryEnvironmental chemicals are capable of interaction with each other and with endogenous substances to minimize or augment their individual toxicities. Interaction between chemicals could take place via the absorption, distribution and excretory routes. Induction and inhibition of the hepatic drug metabolising enzymes also play a significant role in chemical activation, detoxification and interactions. Knowledge of the various mechanisms of toxicity of combined exposure to chemical compounds, in the work or natural environment, are invaluable in predicting their human hazards.

Induction of hepatic drug-metabolising enzymes following treatment of rats and mice with chlordimeform

1985 ◽  
Vol 28 (2-3) ◽  
pp. 143-149 ◽  
Author(s):  
P. Bentley ◽  
W. Stäubli ◽  
F. Bieri ◽  
W. Muecke ◽  
F. Waechter
Keyword(s):  
Hepatic Drug ◽  
Rats And Mice ◽  
Drug Metabolising Enzymes

Hepatic drug metabolising enzymes in undernourished men

Toxicology ◽  
1985 ◽  
Vol 37 (3-4) ◽  
pp. 259-266 ◽  
Author(s):  
Ramesh Rajpurohit ◽  
R. Kalamegham ◽  
A.K. Chary ◽  
Kamala Krishnaswamy
Keyword(s):  
Hepatic Drug ◽  
Drug Metabolising Enzymes

New Applications of Oleanolic Acid and its Derivatives as Cardioprotective Agents: A Review of their Therapeutic Perspectives

2019 ◽  
Vol 25 (35) ◽  
pp. 3740-3750 ◽  
Author(s):  
Ning Sun ◽  
Dongli Li ◽  
Xiaoqing Chen ◽  
Panpan Wu ◽  
Yu-Jing Lu ◽  
...  
Keyword(s):  
Oleanolic Acid ◽  
Liver Diseases ◽  
Therapeutic Agent ◽  
Heart Diseases ◽  
Pentacyclic Triterpenoids ◽  
Hepatic Drug ◽  
Approved Drugs ◽  
New Applications ◽  
Functional Mechanisms ◽  
Potent Therapeutic Agent

Oleanolic acid is an analogue of pentacyclic triterpenoids. It has been used as a hepatic drug for over 20 years in China. Currently, there are only five approved drugs derived from pentacyclic triterpenoids, including oleanolic acid (liver diseases), asiaticoside (wound healing), glycyrrhizinate (liver diseases), isoglycyrrhizinate (liver disease) and sodium aescinate (hydrocephalus). To understand more about the bioactivity and functional mechanisms of oleanolic acid, it can be developed as a potent therapeutic agent, in particular, for the prevention and treatment of heart diseases that are the leading cause of death for people worldwide. The primary aim of this mini-review is to summarize the new applications of oleanolic acid and its derivatives as cardioprotective agents reported in recent years and to highlight their therapeutic perspectives in cardiovascular diseases.

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