A sulfate polysaccharide/TNF-related apoptosis-inducing ligand (TRAIL) complex for the long-term delivery of TRAIL in poly(lactic-co-glycolic acid) (PLGA) microspheres

A dual pH- and temperature-responsive physically crosslinked and injectable hydrogel system was developed for efficient and long-term delivery of oncolytic adenoviruses (Ads).

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Effects of bicarbonate/lactate-buffered neutral peritoneal dialysis fluids on angiogenesis-related proteins in patients undergoing peritoneal dialysis

Renal Replacement Therapy ◽

10.1186/s41100-021-00344-w ◽

2021 ◽

Vol 7 (1) ◽

Author(s):

Hiromichi Ueno ◽

Tetsu Miyamoto ◽

Hiroyuki Morimoto ◽

Kenya Sanada ◽

Ikutaro Furuno ◽

...

Keyword(s):

Peritoneal Dialysis ◽

Antibody Array ◽

The Novel ◽

Term Delivery ◽

Cxc Chemokine ◽

Related Proteins ◽

Chemokine Family ◽

Dialysis Fluids

Abstract Background In order to facilitate the safe and long-term delivery of peritoneal dialysis (PD), it is necessary to improve the biocompatibility of peritoneal dialysis fluids (PDFs). The novel bicarbonate/lactate-buffered neutral PDFs (B/L-PDFs) are expected to be improved biocompatible. This study evaluated the biocompatibility of B/L-PDFs by analysis on the profile of angiogenesis-related proteins in drained dialysate of patients undergoing PD. Methods Concentrations of 20 angiogenesis-related proteins in the dialysate were semi-quantitatively determined using a RayBio® Human Angiogenesis Antibody Array and were compared between B/L-PDFs and conventional lactate-buffered neutral PDFs (L-PDFs). Results The expression of growth-related oncogene (GRO α/β/γ), which belongs to the CXC chemokine family, decreased significantly after use of the B/L-PDFs compared to the L-PDFs (P = 0.03). The number of the proteins with lower level in the B/L-PDFs compared with L-PDFs was significantly negatively correlated with the PD duration (Spearman ρ = − 0.81, P = 0.004). Conclusion This study suggested that B/L-PDFs are more biocompatible than conventional PDFs.

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Long-term delivery of protein therapeutics

Expert Opinion on Drug Delivery ◽

10.1517/17425247.2015.961420 ◽

2014 ◽

Vol 12 (3) ◽

pp. 415-440 ◽

Cited By ~ 99

Author(s):

Ravi Vaishya ◽

Varun Khurana ◽

Sulabh Patel ◽

Ashim K Mitra

Keyword(s):

Protein Therapeutics ◽

Term Delivery

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Long term delivery of glibenclamide from in situ forming microparticles for the treatment of ischemic stroke

Journal of Drug Delivery Science and Technology ◽

10.1016/j.jddst.2021.102860 ◽

2021 ◽

pp. 102860

Author(s):

Hemlata Kaurav ◽

Ashish Sharma ◽

Navneet Kumar Upadhyay ◽

Deepak N. Kapoor

Keyword(s):

Ischemic Stroke ◽

In Situ Forming ◽

Term Delivery

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Back from the brink: a reversible cardiac cause of fetal hydrops

Challenging Concepts in Congenital and Acquired Heart Disease in the Young ◽

10.1093/med/9780198759447.003.0001 ◽

2020 ◽

pp. 1-12

Author(s):

David Lloyd ◽

John Simpson ◽

Vita Zedere

Keyword(s):

Fetal Outcome ◽

Fetal Hydrops ◽

Management Options ◽

Fetal Physiology ◽

Wide Range ◽

Term Delivery ◽

Echocardiographic Assessment ◽

Long Term Prognosis ◽

Full Term Delivery

Fetal hydrops is a form of cardiovascular decompensation unique to fetal physiology, with a wide range of potential causes. In many conditions, it is associated with poor fetal outcome. This chapter explores a challenging case of fetal hydrops, discussing differential diagnoses, methods of echocardiographic assessment, and potential management options. Successful identification and treatment of the underlying cardiac disorder in this case led to complete resolution of hydrops, allowing for full-term delivery, with a good long-term prognosis.

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Engineering microenvironment of biodegradable polyester systems for drug stability and release control

Therapeutic Delivery ◽

10.4155/tde-2020-0113 ◽

2021 ◽

Author(s):

Nisar Ul Khaliq ◽

Dhawal Chobisa ◽

Coralie A Richard ◽

Monica R Swinney ◽

Yoon Yeo

Keyword(s):

Lactic Acid ◽

Glycolic Acid ◽

Release Kinetics ◽

Drug Stability ◽

Poly Lactic Acid ◽

Polymeric Systems ◽

Us Fda ◽

History Of Use ◽

Release Control

Polymeric systems made of poly(lactic acid) or poly(lactic-co-glycolic acid) are widely used for long-term delivery of small and large molecules. The advantages of poly(lactic acid)/poly(lactic-co-glycolic acid) systems include biodegradability, safety and a long history of use in US FDA-approved products. However, as drugs delivered by the polymeric systems and their applications become more diverse, the significance of microenvironment change of degrading systems on long-term drug stability and release kinetics has gained renewed attention. In this review, we discuss various issues experienced with acidifying microenvironment of biodegradable polymer systems and approaches to overcome the detrimental effects of polymer degradation on drug stability and release control.

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Development of an antimicrobial peptide-loaded mineralized collagen bone scaffold for infective bone defect repair

Regenerative Biomaterials ◽

10.1093/rb/rbaa015 ◽

2020 ◽

Vol 7 (5) ◽

pp. 515-525

Author(s):

Yuzhu He ◽

Yahui Jin ◽

Xiaoxia Ying ◽

Qiong Wu ◽

Shenglian Yao ◽

...

Keyword(s):

Antibacterial Properties ◽

Clinical Work ◽

Bone Defects ◽

Mechanical Tests ◽

Great Promise ◽

Plga Microspheres ◽

Bone Scaffold ◽

Defect Repair ◽

Mineralized Collagen

Abstract The repair of infective bone defects is a great challenge in clinical work. It is of vital importance to develop a kind of bone scaffold with good osteogenic properties and long-term antibacterial activity for local anti-infection and bone regeneration. A porous mineralized collagen (MC) scaffold containing poly(d,l-lactide-co-glycolic acid) (PLGA) microspheres loaded with two antibacterial synthetic peptides, Pac-525 or KSL-W was developed and characterized via scanning electron microscopy (SEM), porosity measurement, swelling and mechanical tests. The results showed that the MC scaffold embedded with smooth and compact PLGA microspheres had a positive effect on cell growth and also had antibacterial properties. Through toxicity analysis, cell morphology and proliferation analysis and alkaline phosphatase evaluation, the antibacterial scaffolds showed excellent biocompatibility and osteogenic activity. The antibacterial property evaluated with Staphylococcus aureus and Escherichia coli suggested that the sustained release of Pac-525 or KSL-W from the scaffolds could inhibit the bacterial growth aforementioned in the long term. Our results suggest that the antimicrobial peptides-loaded MC bone scaffold has good antibacterial and osteogenic activities, thus providing a great promise for the treatment of infective bone defects.

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