scholarly journals Long-term delivery of protein therapeutics

2014 ◽  
Vol 12 (3) ◽  
pp. 415-440 ◽  
Author(s):  
Ravi Vaishya ◽  
Varun Khurana ◽  
Sulabh Patel ◽  
Ashim K Mitra
Keyword(s):  
Protein Therapeutics ◽  
Term Delivery

scholarly journals Capsosomes as Long-Term Delivery Vehicles for Protein Therapeutics

Langmuir ◽  
2015 ◽  
Vol 31 (28) ◽  
pp. 7776-7781 ◽  
Author(s):  
James W. Maina ◽  
Joseph J. Richardson ◽  
Rona Chandrawati ◽  
Kristian Kempe ◽  
Martin P. van Koeverden ◽  
...  
Keyword(s):  
Protein Therapeutics ◽  
Term Delivery ◽  
Delivery Vehicles

scholarly journals How long is long-term? Delivery of anti-HIV antibodies using AAV vector

2019 ◽  
Vol 5 ◽  
pp. 49
Author(s):  
J. Martinez-Navio ◽  
R. Desrosiers ◽  
S. Fuchs ◽  
D. Mendes ◽  
E. Rakasz ◽  
...  
Keyword(s):  
Aav Vector ◽  
Term Delivery ◽  
Hiv Antibodies ◽  
Anti Hiv

Physically crosslinked injectable hydrogels for long-term delivery of oncolytic adenoviruses for cancer treatment

2019 ◽  
Vol 7 (10) ◽  
pp. 4195-4207 ◽  
Author(s):  
Thai Minh Duy Le ◽  
Bo-Kyeong Jung ◽  
Yi Li ◽  
Huu Thuy Trang Duong ◽  
Thanh Loc Nguyen ◽  
...  
Keyword(s):  
Cancer Treatment ◽  
Injectable Hydrogels ◽  
Injectable Hydrogel ◽  
Temperature Responsive ◽  
Oncolytic Adenoviruses ◽  
Term Delivery ◽  
Physically Crosslinked ◽  
Hydrogel System

A dual pH- and temperature-responsive physically crosslinked and injectable hydrogel system was developed for efficient and long-term delivery of oncolytic adenoviruses (Ads).

scholarly journals Effects of bicarbonate/lactate-buffered neutral peritoneal dialysis fluids on angiogenesis-related proteins in patients undergoing peritoneal dialysis

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Hiromichi Ueno ◽  
Tetsu Miyamoto ◽  
Hiroyuki Morimoto ◽  
Kenya Sanada ◽  
Ikutaro Furuno ◽  
...  
Keyword(s):  
Peritoneal Dialysis ◽  
Antibody Array ◽  
The Novel ◽  
Term Delivery ◽  
Cxc Chemokine ◽  
Related Proteins ◽  
Chemokine Family ◽  
Dialysis Fluids

Abstract Background In order to facilitate the safe and long-term delivery of peritoneal dialysis (PD), it is necessary to improve the biocompatibility of peritoneal dialysis fluids (PDFs). The novel bicarbonate/lactate-buffered neutral PDFs (B/L-PDFs) are expected to be improved biocompatible. This study evaluated the biocompatibility of B/L-PDFs by analysis on the profile of angiogenesis-related proteins in drained dialysate of patients undergoing PD. Methods Concentrations of 20 angiogenesis-related proteins in the dialysate were semi-quantitatively determined using a RayBio® Human Angiogenesis Antibody Array and were compared between B/L-PDFs and conventional lactate-buffered neutral PDFs (L-PDFs). Results The expression of growth-related oncogene (GRO α/β/γ), which belongs to the CXC chemokine family, decreased significantly after use of the B/L-PDFs compared to the L-PDFs (P = 0.03). The number of the proteins with lower level in the B/L-PDFs compared with L-PDFs was significantly negatively correlated with the PD duration (Spearman ρ = − 0.81, P = 0.004). Conclusion This study suggested that B/L-PDFs are more biocompatible than conventional PDFs.

Back from the brink: a reversible cardiac cause of fetal hydrops

2020 ◽  
pp. 1-12
Author(s):  
David Lloyd ◽  
John Simpson ◽  
Vita Zedere
Keyword(s):  
Fetal Outcome ◽  
Fetal Hydrops ◽  
Management Options ◽  
Fetal Physiology ◽  
Wide Range ◽  
Term Delivery ◽  
Echocardiographic Assessment ◽  
Long Term Prognosis ◽  
Full Term Delivery

Fetal hydrops is a form of cardiovascular decompensation unique to fetal physiology, with a wide range of potential causes. In many conditions, it is associated with poor fetal outcome. This chapter explores a challenging case of fetal hydrops, discussing differential diagnoses, methods of echocardiographic assessment, and potential management options. Successful identification and treatment of the underlying cardiac disorder in this case led to complete resolution of hydrops, allowing for full-term delivery, with a good long-term prognosis.

Ferrous sulfate-directed dual-cross-linked hyaluronic acid hydrogels with long-term delivery of donepezil

2020 ◽  
Vol 582 ◽  
pp. 119309 ◽  
Author(s):  
Song Yi Lee ◽  
Ju-Hwan Park ◽  
Mingyu Yang ◽  
Min-Jun Baek ◽  
Min-Hwan Kim ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Ferrous Sulfate ◽  
Term Delivery

Effect of local, long-term delivery of platelet-derived growth factor (PDGF) on injected fat graft survival in severe combined immunodeficient (SCID) mice

2009 ◽  
Vol 62 (2) ◽  
pp. 235-243 ◽  
Author(s):  
Randall O. Craft ◽  
John Rophael ◽  
Wayne A. Morrison ◽  
Aditya V. Vashi ◽  
Geraldine M. Mitchell ◽  
...  
Keyword(s):  
Growth Factor ◽  
Graft Survival ◽  
Scid Mice ◽  
Platelet Derived Growth Factor ◽  
Fat Graft ◽  
Term Delivery

scholarly journals Subcutaneous Implants of Buprenorphine-Cholesterol-Triglyceride Powder in Mice

2014 ◽  
Vol 2014 ◽  
pp. 1-8 ◽  
Author(s):  
L. DeTolla ◽  
R. Sanchez ◽  
E. Khan ◽  
B. Tyler ◽  
M. Guarnieri
Keyword(s):  
Clinical Pathology ◽  
Test System ◽  
Clinical Observations ◽  
Safety Test ◽  
Term Delivery ◽  
Low Toxicity ◽  
Animal Safety ◽  
Higher Doses ◽  
Drug Implants

Subcutaneous drug implants are convenient systems for the long-term delivery of drugs in animals. Lipid carriers are logical tools because they generally allow for higher doses and low toxicity. The present study used an US Food and Drug Administration Target Animal Safety test system to evaluate the safety of a subcutaneous implant of a cholesterol-triglyceride-buprenorphine powder in 120 BALB/c mice. Mice were evaluated in 4- and 12-day trials with 1- and 5-fold doses of the intended 3 mg/kg dose of drug. One male mouse treated with three 3 mg/kg doses and surgery on days 0, 4, and 8 died on day 9. The cause of death was not determined. In the surviving 119 mice there was no evidence of skin reaction at the site of the implant. Compared to control animals treated with saline, weight measurements, clinical pathology, histopathology, and clinical observations were unremarkable. These results demonstrate that the lipid carrier is substantially safe. Cholesterol-triglyceride-drug powders may provide a valuable research tool for studies of analgesic and inflammatory drug implants in veterinary medicine.

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