Increases in repolarization heterogeneity predict left ventricular systolic dysfunction and response to cardiac resynchronization therapy in patients with left bundle branch block

2020 ◽  
Vol 31 (7) ◽  
pp. 1770-1778
Author(s):  
Hui‐Chun Huang ◽  
Kuo‐Liong Chien ◽  
Yi‐Chung Chang ◽  
Lian‐Yu Lin ◽  
Jui Wang ◽  
...  
2019 ◽  
Vol 3 (4) ◽  
pp. 1-5
Author(s):  
Haqeel A Jamil ◽  
Steven L Goldberg ◽  
Klaus K Witte

Abstract Background  Symptomatic patients with significant left ventricular systolic dysfunction (LVSD) require a tailored treatment approach. Both functional mitral regurgitation (FMR) and left bundle branch block (LBBB) can develop, contributing to clinical deterioration, and worse prognosis despite optimal medical therapy (OMT). Case summary  We report the case of a symptomatic 60-year-old man on OMT with LVSD and significant FMR. His symptoms and FMR initially improved following transvenous mitral annuloplasty using the Carillon® Mitral Contour System® annuloplasty device. However, he subsequently developed LBBB with associated reduction in exercise capacity, for which he underwent cardiac resynchronization therapy, and ensuing symptom improvement and stabilization. Discussion  Our case describes how targeted device interventions can be combined synergistically to optimize patient symptoms.


JAMA ◽  
2007 ◽  
Vol 297 (22) ◽  
pp. 2502 ◽  
Author(s):  
Finlay A. McAlister ◽  
Justin Ezekowitz ◽  
Nicola Hooton ◽  
Ben Vandermeer ◽  
Carol Spooner ◽  
...  

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