Characteristics of ventricular tachyarrhythmias and their susceptibility to antitachycardia pacing termination in patients with ischemic and nonischemic cardiomyopathy: A patient‐level meta‐analysis of three large clinical trials

2020 ◽  
Vol 31 (10) ◽  
pp. 2720-2726 ◽  
Author(s):  
Alan Cheng ◽  
Boyoung Joung ◽  
Mark L. Brown ◽  
Jodi Koehler ◽  
Daniel R. Lexcen ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Meta Analysis ◽  
Ventricular Tachyarrhythmias ◽  
Nonischemic Cardiomyopathy ◽  
Antitachycardia Pacing ◽  
Patient Level

META-ANALYSIS OF PATIENT-LEVEL CLINICAL TRIALS DATA

2004 ◽  
Vol 99 ◽  
pp. S249
Author(s):  
Lloyd R. Sutherland ◽  
Peter D. Faris ◽  
Mahnaz Youssefi ◽  
Deborah Hogerman ◽  
Christopher F. Martin ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Meta Analysis ◽  
Patient Level

The misleading concept of initial severity in depression clinical trials: development and results from a mathematical model

2016 ◽  
Vol 25 (1) ◽  
pp. 18-20 ◽  
Author(s):  
Konstantinos N Fountoulakis
Keyword(s):  
Mathematical Model ◽  
Clinical Trials ◽  
Treatment Efficacy ◽  
Positive Relationship ◽  
Meta Analysis ◽  
True Nature ◽  
Patient Level ◽  
Initial Severity ◽  
Artificial Datasets

Objective: Recently, meta-analytic studies have suggested a positive relationship between initial severity and magnitude of treatment efficacy. The aim of the current study was to develop a mathematical model to test the assumption concerning the role of initial severity in treatment response. Methods: A number of experimental artificial datasets were developed on the basis of three different scenarios which reflect a pre-determined effect of initial severity. They were used to test for correlations at the patient level as well as at the meta-analysis level (trial level). Results: The results suggested that in all scenarios and analyses the correlations were so high that a ceiling effect was obvious. The testing concerned changes from baseline, but not differences between arms. Conclusions: Overall the data suggest that the question concerning the role of initial severity cannot be answered. Any allegations on such a role are based on flawed methodology and do not take into consideration the true nature of data.

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