scholarly journals Low-intensity pulsed ultrasound attenuates cardiac inflammation of CVB3-induced viral myocarditis via regulation of caveolin-1 and MAPK pathways

2018 ◽  
Vol 23 (3) ◽  
pp. 1963-1975 ◽  
Author(s):  
Cheng Zheng ◽  
Sen-Min Wu ◽  
Hao Lian ◽  
Yuan-Zheng Lin ◽  
Rong Zhuang ◽  
...  
Keyword(s):  
Viral Myocarditis ◽  
Pulsed Ultrasound ◽  
Cardiac Inflammation ◽  
Caveolin 1 ◽  
Low Intensity Pulsed Ultrasound ◽  
Low Intensity ◽  
Mapk Pathways

scholarly journals Improved activity of MC3T3-E1 cells by the exciting piezoelectric BaTiO3/TC4 using low-intensity pulsed ultrasound

2021 ◽  
Vol 6 (11) ◽  
pp. 4073-4082
Author(s):  
Kunzhan Cai ◽  
Yilai Jiao ◽  
Quan Quan ◽  
Yulin Hao ◽  
Jie Liu ◽  
...  
Keyword(s):  
Pulsed Ultrasound ◽  
Low Intensity Pulsed Ultrasound ◽  
Low Intensity

scholarly journals Development and Validation of Low-Intensity Pulsed Ultrasound Systems for Highly Controlled in vitro Cell Stimulation

Ultrasonics ◽  
2021 ◽  
pp. 106495
Author(s):  
F. Fontana ◽  
F. Iberite ◽  
A. Cafarelli ◽  
A. Aliperta ◽  
G. Baldi ◽  
...  
Keyword(s):  
Pulsed Ultrasound ◽  
Cell Stimulation ◽  
Low Intensity Pulsed Ultrasound ◽  
Low Intensity ◽  
Development And Validation

scholarly journals Osteocytes as main responders to low-intensity pulsed ultrasound treatment during fracture healing

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Tatsuya Shimizu ◽  
Naomasa Fujita ◽  
Kiyomi Tsuji-Tamura ◽  
Yoshimasa Kitagawa ◽  
Toshiaki Fujisawa ◽  
...  
Keyword(s):  
Fracture Healing ◽  
Transcriptional Control ◽  
Target Genes ◽  
Pulsed Ultrasound ◽  
Activated T Cells ◽  
In Vivo Models ◽  
Low Intensity Pulsed Ultrasound ◽  
Low Intensity ◽  
Ultrasound Stimulation

AbstractUltrasound stimulation is a type of mechanical stress, and low-intensity pulsed ultrasound (LIPUS) devices have been used clinically to promote fracture healing. However, it remains unclear which skeletal cells, in particular osteocytes or osteoblasts, primarily respond to LIPUS stimulation and how they contribute to fracture healing. To examine this, we utilized medaka, whose bone lacks osteocytes, and zebrafish, whose bone has osteocytes, as in vivo models. Fracture healing was accelerated by ultrasound stimulation in zebrafish, but not in medaka. To examine the molecular events induced by LIPUS stimulation in osteocytes, we performed RNA sequencing of a murine osteocytic cell line exposed to LIPUS. 179 genes reacted to LIPUS stimulation, and functional cluster analysis identified among them several molecular signatures related to immunity, secretion, and transcription. Notably, most of the isolated transcription-related genes were also modulated by LIPUS in vivo in zebrafish. However, expression levels of early growth response protein 1 and 2 (Egr1, 2), JunB, forkhead box Q1 (FoxQ1), and nuclear factor of activated T cells c1 (NFATc1) were not altered by LIPUS in medaka, suggesting that these genes are key transcriptional regulators of LIPUS-dependent fracture healing via osteocytes. We therefore show that bone-embedded osteocytes are necessary for LIPUS-induced promotion of fracture healing via transcriptional control of target genes, which presumably activates neighboring cells involved in fracture healing processes.

Low-intensity pulsed ultrasound affects RUNX2 immunopositive osteogenic cells in delayed clinical fracture healing

Bone ◽  
2009 ◽  
Vol 45 (5) ◽  
pp. 862-869 ◽  
Author(s):  
Sjoerd Rutten ◽  
Peter A. Nolte ◽  
Clara M. Korstjens ◽  
Jenneke Klein-Nulend
Keyword(s):  
Fracture Healing ◽  
Pulsed Ultrasound ◽  
Low Intensity Pulsed Ultrasound ◽  
Osteogenic Cells ◽  
Low Intensity ◽  
Clinical Fracture

scholarly journals The effect of low intensity pulsed ultrasound on mandibular condylar growth in young adult rats

Bone Reports ◽  
2021 ◽  
pp. 101122
Author(s):  
Yasamin Hadaegh ◽  
Hasan Uludag ◽  
Douglas Dederich ◽  
Tarek H. El-Bialy
Keyword(s):  
Young Adult ◽  
Pulsed Ultrasound ◽  
Adult Rats ◽  
Low Intensity Pulsed Ultrasound ◽  
Low Intensity

Low-Intensity Pulsed Ultrasound Accelerates Rat Femoral Fracture Healing by Acting on the Various Cellular Reactions in the Fracture Callus

2001 ◽  
Vol 16 (4) ◽  
pp. 671-680 ◽  
Author(s):  
Yoshiaki Azuma ◽  
Masaya Ito ◽  
Yoshifumi Harada ◽  
Hideko Takagi ◽  
Tomohiro Ohta ◽  
...  
Keyword(s):  
Fracture Healing ◽  
Femoral Fracture ◽  
Pulsed Ultrasound ◽  
Fracture Callus ◽  
Low Intensity Pulsed Ultrasound ◽  
Low Intensity
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